Clinical characteristics and prognostic factors in hypertensive anterior uveitis diagnosed with polymerase chain reaction

Abstract Aim of the study is to report the clinical characteristics and prognostic factors in hypertensive anterior uveitis (AU) diagnosed with multiplex polymerase chain reaction (PCR). Eighty-eight eyes of 88 patients with hypertensive AU were enrolled from 2015 to 2019 in a tertiary center in Sou...

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Autores principales:	Woong-Sun Yoo, Gyu-Nam Kim, Inyoung Chung, Min-Chul Cho, Yong Seop Han, Sang Soo Kang, Seung Pil Yun, Seong-Wook Seo, Seong-Jae Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/00c3810c5912405582e864a6fc4b030a
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spelling	oai:doaj.org-article:00c3810c5912405582e864a6fc4b030a2021-12-02T16:45:15ZClinical characteristics and prognostic factors in hypertensive anterior uveitis diagnosed with polymerase chain reaction10.1038/s41598-021-87931-32045-2322https://doaj.org/article/00c3810c5912405582e864a6fc4b030a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87931-3https://doaj.org/toc/2045-2322Abstract Aim of the study is to report the clinical characteristics and prognostic factors in hypertensive anterior uveitis (AU) diagnosed with multiplex polymerase chain reaction (PCR). Eighty-eight eyes of 88 patients with hypertensive AU were enrolled from 2015 to 2019 in a tertiary center in South Korea. All patients underwent multiplex PCR that was performed using aqueous humor samples collected at first visit to detect the DNA of six herpesviruses. Twenty-eight (31.8%) eyes were PCR positive. Herpes simplex virus was found in 6 (6.8%) eyes, varicella-zoster virus in 7 (8.0%) eyes, cytomegalovirus in 14 (15.9%) eyes, and Epstein–Barr virus in 1 (1.1%) eye. On multivariate regression analysis, PCR positivity was significantly associated with coin-shaped keratic precipitates (odds ratio (OR) = 6.01, P = 0.044). Recurrence and final visual acuity were significantly associated with a presumed diagnosis of viral endotheliitis (OR = 21.69, P = 0.04 and OR = 6.3, P = 0.004, respectively). This study showed the importance of PCR positivity, suggesting that identification of the virus through active PCR testing could affect the course, treatment, and prognosis of hypertensive AU.Woong-Sun YooGyu-Nam KimInyoung ChungMin-Chul ChoYong Seop HanSang Soo KangSeung Pil YunSeong-Wook SeoSeong-Jae KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Woong-Sun Yoo Gyu-Nam Kim Inyoung Chung Min-Chul Cho Yong Seop Han Sang Soo Kang Seung Pil Yun Seong-Wook Seo Seong-Jae Kim Clinical characteristics and prognostic factors in hypertensive anterior uveitis diagnosed with polymerase chain reaction
description	Abstract Aim of the study is to report the clinical characteristics and prognostic factors in hypertensive anterior uveitis (AU) diagnosed with multiplex polymerase chain reaction (PCR). Eighty-eight eyes of 88 patients with hypertensive AU were enrolled from 2015 to 2019 in a tertiary center in South Korea. All patients underwent multiplex PCR that was performed using aqueous humor samples collected at first visit to detect the DNA of six herpesviruses. Twenty-eight (31.8%) eyes were PCR positive. Herpes simplex virus was found in 6 (6.8%) eyes, varicella-zoster virus in 7 (8.0%) eyes, cytomegalovirus in 14 (15.9%) eyes, and Epstein–Barr virus in 1 (1.1%) eye. On multivariate regression analysis, PCR positivity was significantly associated with coin-shaped keratic precipitates (odds ratio (OR) = 6.01, P = 0.044). Recurrence and final visual acuity were significantly associated with a presumed diagnosis of viral endotheliitis (OR = 21.69, P = 0.04 and OR = 6.3, P = 0.004, respectively). This study showed the importance of PCR positivity, suggesting that identification of the virus through active PCR testing could affect the course, treatment, and prognosis of hypertensive AU.
format	article
author	Woong-Sun Yoo Gyu-Nam Kim Inyoung Chung Min-Chul Cho Yong Seop Han Sang Soo Kang Seung Pil Yun Seong-Wook Seo Seong-Jae Kim
author_facet	Woong-Sun Yoo Gyu-Nam Kim Inyoung Chung Min-Chul Cho Yong Seop Han Sang Soo Kang Seung Pil Yun Seong-Wook Seo Seong-Jae Kim
author_sort	Woong-Sun Yoo
title	Clinical characteristics and prognostic factors in hypertensive anterior uveitis diagnosed with polymerase chain reaction
title_short	Clinical characteristics and prognostic factors in hypertensive anterior uveitis diagnosed with polymerase chain reaction
title_full	Clinical characteristics and prognostic factors in hypertensive anterior uveitis diagnosed with polymerase chain reaction
title_fullStr	Clinical characteristics and prognostic factors in hypertensive anterior uveitis diagnosed with polymerase chain reaction
title_full_unstemmed	Clinical characteristics and prognostic factors in hypertensive anterior uveitis diagnosed with polymerase chain reaction
title_sort	clinical characteristics and prognostic factors in hypertensive anterior uveitis diagnosed with polymerase chain reaction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/00c3810c5912405582e864a6fc4b030a
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Clinical characteristics and prognostic factors in hypertensive anterior uveitis diagnosed with polymerase chain reaction

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