Effects of highly selective sympathectomy on neurogenic bowel dysfunction in spinal cord injury rats

Abstract Neurogenic bowel dysfunction, including hyperreflexic and areflexic bowel, is a common complication in patients with spinal cord injury (SCI). We hypothesized that removing part of the colonic sympathetic innervation can alleviate the hyperreflexic bowel, and investigated the effect of symp...

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Autores principales:	Peipei Xu, Shuang Guo, Yang Xie, Zitong Liu, Changbin Liu, Xin Zhang, Degang Yang, Huiming Gong, Yixin Chen, Liangjie Du, Yan Yu, Mingliang Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/00c3b344a2014670bdcc051a83255360
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spelling	oai:doaj.org-article:00c3b344a2014670bdcc051a832553602021-12-02T16:35:46ZEffects of highly selective sympathectomy on neurogenic bowel dysfunction in spinal cord injury rats10.1038/s41598-021-95158-52045-2322https://doaj.org/article/00c3b344a2014670bdcc051a832553602021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95158-5https://doaj.org/toc/2045-2322Abstract Neurogenic bowel dysfunction, including hyperreflexic and areflexic bowel, is a common complication in patients with spinal cord injury (SCI). We hypothesized that removing part of the colonic sympathetic innervation can alleviate the hyperreflexic bowel, and investigated the effect of sympathectomy on the hyperreflexic bowel of SCI rats. The peri-arterial sympathectomy of the inferior mesenteric artery (PSIMA) was performed in T8 SCI rats. The defecation habits of rats, the water content of fresh faeces, the intestinal transmission function, the defecation pressure of the distal colon, and the down-regulation of Alpha-2 adrenergic receptors in colon secondary to PSIMA were evaluated. The incidence of typical hyperreflexic bowel was 95% in SCI rats. Compared to SCI control rats, PSIMA increased the faecal water content of SCI rats by 5–13% (P < 0.05), the emptying rate of the faeces in colon within 24 h by 14–40% (P < 0.05), and the defecation pressure of colon by 10–11 mmHg (P < 0.05). These effects lasted for at least 12 weeks after PSIMA. Immunofluorescence label showed the secondary down-regulation of Alpha-2 adrenergic receptors after PSIMA occurred mainly in rats’ distal colon. PSIMA mainly removes the sympathetic innervation of the distal colon, and can relieve the hyperreflexic bowel in rats with SCI. The possible mechanism is to reduce the inhibitory effect of sympathetic activity, and enhance the regulatory effect of parasympathetic activity on the colon. This procedure could potentially be used for hyperreflexic bowel in patients with SCI.Peipei XuShuang GuoYang XieZitong LiuChangbin LiuXin ZhangDegang YangHuiming GongYixin ChenLiangjie DuYan YuMingliang YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peipei Xu Shuang Guo Yang Xie Zitong Liu Changbin Liu Xin Zhang Degang Yang Huiming Gong Yixin Chen Liangjie Du Yan Yu Mingliang Yang Effects of highly selective sympathectomy on neurogenic bowel dysfunction in spinal cord injury rats
description	Abstract Neurogenic bowel dysfunction, including hyperreflexic and areflexic bowel, is a common complication in patients with spinal cord injury (SCI). We hypothesized that removing part of the colonic sympathetic innervation can alleviate the hyperreflexic bowel, and investigated the effect of sympathectomy on the hyperreflexic bowel of SCI rats. The peri-arterial sympathectomy of the inferior mesenteric artery (PSIMA) was performed in T8 SCI rats. The defecation habits of rats, the water content of fresh faeces, the intestinal transmission function, the defecation pressure of the distal colon, and the down-regulation of Alpha-2 adrenergic receptors in colon secondary to PSIMA were evaluated. The incidence of typical hyperreflexic bowel was 95% in SCI rats. Compared to SCI control rats, PSIMA increased the faecal water content of SCI rats by 5–13% (P < 0.05), the emptying rate of the faeces in colon within 24 h by 14–40% (P < 0.05), and the defecation pressure of colon by 10–11 mmHg (P < 0.05). These effects lasted for at least 12 weeks after PSIMA. Immunofluorescence label showed the secondary down-regulation of Alpha-2 adrenergic receptors after PSIMA occurred mainly in rats’ distal colon. PSIMA mainly removes the sympathetic innervation of the distal colon, and can relieve the hyperreflexic bowel in rats with SCI. The possible mechanism is to reduce the inhibitory effect of sympathetic activity, and enhance the regulatory effect of parasympathetic activity on the colon. This procedure could potentially be used for hyperreflexic bowel in patients with SCI.
format	article
author	Peipei Xu Shuang Guo Yang Xie Zitong Liu Changbin Liu Xin Zhang Degang Yang Huiming Gong Yixin Chen Liangjie Du Yan Yu Mingliang Yang
author_facet	Peipei Xu Shuang Guo Yang Xie Zitong Liu Changbin Liu Xin Zhang Degang Yang Huiming Gong Yixin Chen Liangjie Du Yan Yu Mingliang Yang
author_sort	Peipei Xu
title	Effects of highly selective sympathectomy on neurogenic bowel dysfunction in spinal cord injury rats
title_short	Effects of highly selective sympathectomy on neurogenic bowel dysfunction in spinal cord injury rats
title_full	Effects of highly selective sympathectomy on neurogenic bowel dysfunction in spinal cord injury rats
title_fullStr	Effects of highly selective sympathectomy on neurogenic bowel dysfunction in spinal cord injury rats
title_full_unstemmed	Effects of highly selective sympathectomy on neurogenic bowel dysfunction in spinal cord injury rats
title_sort	effects of highly selective sympathectomy on neurogenic bowel dysfunction in spinal cord injury rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/00c3b344a2014670bdcc051a83255360
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Effects of highly selective sympathectomy on neurogenic bowel dysfunction in spinal cord injury rats

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