Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway

Circadian clock regulates hepatic gene expression and functions. Here Chao et al. show that alteration of circadian clock genes by Period deletion induces polyploidy in hepatocytes due to impaired regulation of Erk signaling by mitogen-activated protein kinase phosphatase 1.

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Autores principales:	Hsu-Wen Chao, Masao Doi, Jean-Michel Fustin, Huatao Chen, Kimihiko Murase, Yuki Maeda, Hida Hayashi, Rina Tanaka, Maho Sugawa, Naoki Mizukuchi, Yoshiaki Yamaguchi, Jun-ichirou Yasunaga, Masao Matsuoka, Mashito Sakai, Michihiro Matsumoto, Shinshichi Hamada, Hitoshi Okamura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/00c4c91b8a014bdc961074b75b4bbb0b
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spelling	oai:doaj.org-article:00c4c91b8a014bdc961074b75b4bbb0b2021-12-02T15:38:47ZCircadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway10.1038/s41467-017-02207-72041-1723https://doaj.org/article/00c4c91b8a014bdc961074b75b4bbb0b2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02207-7https://doaj.org/toc/2041-1723Circadian clock regulates hepatic gene expression and functions. Here Chao et al. show that alteration of circadian clock genes by Period deletion induces polyploidy in hepatocytes due to impaired regulation of Erk signaling by mitogen-activated protein kinase phosphatase 1.Hsu-Wen ChaoMasao DoiJean-Michel FustinHuatao ChenKimihiko MuraseYuki MaedaHida HayashiRina TanakaMaho SugawaNaoki MizukuchiYoshiaki YamaguchiJun-ichirou YasunagaMasao MatsuokaMashito SakaiMichihiro MatsumotoShinshichi HamadaHitoshi OkamuraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hsu-Wen Chao Masao Doi Jean-Michel Fustin Huatao Chen Kimihiko Murase Yuki Maeda Hida Hayashi Rina Tanaka Maho Sugawa Naoki Mizukuchi Yoshiaki Yamaguchi Jun-ichirou Yasunaga Masao Matsuoka Mashito Sakai Michihiro Matsumoto Shinshichi Hamada Hitoshi Okamura Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway
description	Circadian clock regulates hepatic gene expression and functions. Here Chao et al. show that alteration of circadian clock genes by Period deletion induces polyploidy in hepatocytes due to impaired regulation of Erk signaling by mitogen-activated protein kinase phosphatase 1.
format	article
author	Hsu-Wen Chao Masao Doi Jean-Michel Fustin Huatao Chen Kimihiko Murase Yuki Maeda Hida Hayashi Rina Tanaka Maho Sugawa Naoki Mizukuchi Yoshiaki Yamaguchi Jun-ichirou Yasunaga Masao Matsuoka Mashito Sakai Michihiro Matsumoto Shinshichi Hamada Hitoshi Okamura
author_facet	Hsu-Wen Chao Masao Doi Jean-Michel Fustin Huatao Chen Kimihiko Murase Yuki Maeda Hida Hayashi Rina Tanaka Maho Sugawa Naoki Mizukuchi Yoshiaki Yamaguchi Jun-ichirou Yasunaga Masao Matsuoka Mashito Sakai Michihiro Matsumoto Shinshichi Hamada Hitoshi Okamura
author_sort	Hsu-Wen Chao
title	Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway
title_short	Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway
title_full	Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway
title_fullStr	Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway
title_full_unstemmed	Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway
title_sort	circadian clock regulates hepatic polyploidy by modulating mkp1-erk1/2 signaling pathway
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/00c4c91b8a014bdc961074b75b4bbb0b
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Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway

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