Ventral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice

Acute stress transiently disrupts reward-seeking behaviour and repeated stress exposure produces lasting anhedonia-like behaviour in rodents. Here, the authors show that stress triggers GABAergic activity in the ventral tegmental area which blunts reward-seeking behaviour in mice.

Guardado en:
Detalles Bibliográficos
Autores principales: Daniel C. Lowes, Linda A. Chamberlin, Lisa N. Kretsge, Emma S. Holt, Atheir I. Abbas, Alan J. Park, Lyubov Yusufova, Zachary H. Bretton, Ayesha Firdous, Armen G. Enikolopov, Joshua A. Gordon, Alexander Z. Harris
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Q
Acceso en línea:https://doaj.org/article/00c4ef5a5a704504b5b5820961797043
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Acute stress transiently disrupts reward-seeking behaviour and repeated stress exposure produces lasting anhedonia-like behaviour in rodents. Here, the authors show that stress triggers GABAergic activity in the ventral tegmental area which blunts reward-seeking behaviour in mice.