Ventral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice

Acute stress transiently disrupts reward-seeking behaviour and repeated stress exposure produces lasting anhedonia-like behaviour in rodents. Here, the authors show that stress triggers GABAergic activity in the ventral tegmental area which blunts reward-seeking behaviour in mice.

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Autores principales:	Daniel C. Lowes, Linda A. Chamberlin, Lisa N. Kretsge, Emma S. Holt, Atheir I. Abbas, Alan J. Park, Lyubov Yusufova, Zachary H. Bretton, Ayesha Firdous, Armen G. Enikolopov, Joshua A. Gordon, Alexander Z. Harris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/00c4ef5a5a704504b5b5820961797043
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spelling	oai:doaj.org-article:00c4ef5a5a704504b5b58209617970432021-12-02T17:38:25ZVentral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice10.1038/s41467-021-23906-22041-1723https://doaj.org/article/00c4ef5a5a704504b5b58209617970432021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23906-2https://doaj.org/toc/2041-1723Acute stress transiently disrupts reward-seeking behaviour and repeated stress exposure produces lasting anhedonia-like behaviour in rodents. Here, the authors show that stress triggers GABAergic activity in the ventral tegmental area which blunts reward-seeking behaviour in mice.Daniel C. LowesLinda A. ChamberlinLisa N. KretsgeEmma S. HoltAtheir I. AbbasAlan J. ParkLyubov YusufovaZachary H. BrettonAyesha FirdousArmen G. EnikolopovJoshua A. GordonAlexander Z. HarrisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel C. Lowes Linda A. Chamberlin Lisa N. Kretsge Emma S. Holt Atheir I. Abbas Alan J. Park Lyubov Yusufova Zachary H. Bretton Ayesha Firdous Armen G. Enikolopov Joshua A. Gordon Alexander Z. Harris Ventral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice
description	Acute stress transiently disrupts reward-seeking behaviour and repeated stress exposure produces lasting anhedonia-like behaviour in rodents. Here, the authors show that stress triggers GABAergic activity in the ventral tegmental area which blunts reward-seeking behaviour in mice.
format	article
author	Daniel C. Lowes Linda A. Chamberlin Lisa N. Kretsge Emma S. Holt Atheir I. Abbas Alan J. Park Lyubov Yusufova Zachary H. Bretton Ayesha Firdous Armen G. Enikolopov Joshua A. Gordon Alexander Z. Harris
author_facet	Daniel C. Lowes Linda A. Chamberlin Lisa N. Kretsge Emma S. Holt Atheir I. Abbas Alan J. Park Lyubov Yusufova Zachary H. Bretton Ayesha Firdous Armen G. Enikolopov Joshua A. Gordon Alexander Z. Harris
author_sort	Daniel C. Lowes
title	Ventral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice
title_short	Ventral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice
title_full	Ventral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice
title_fullStr	Ventral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice
title_full_unstemmed	Ventral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice
title_sort	ventral tegmental area gaba neurons mediate stress-induced blunted reward-seeking in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/00c4ef5a5a704504b5b5820961797043
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Ventral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice

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