Ventral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice
Acute stress transiently disrupts reward-seeking behaviour and repeated stress exposure produces lasting anhedonia-like behaviour in rodents. Here, the authors show that stress triggers GABAergic activity in the ventral tegmental area which blunts reward-seeking behaviour in mice.
Guardado en:
Autores principales: | Daniel C. Lowes, Linda A. Chamberlin, Lisa N. Kretsge, Emma S. Holt, Atheir I. Abbas, Alan J. Park, Lyubov Yusufova, Zachary H. Bretton, Ayesha Firdous, Armen G. Enikolopov, Joshua A. Gordon, Alexander Z. Harris |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/00c4ef5a5a704504b5b5820961797043 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents
por: Christian Büchel, et al.
Publicado: (2017) -
Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement
por: Ji Hoon Yoo, et al.
Publicado: (2016) -
Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice
por: Akira Mizoguchi, et al.
Publicado: (2021) -
Ventral tegmental area astrocytes orchestrate avoidance and approach behavior
por: J. A. Gomez, et al.
Publicado: (2019) -
Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area
por: Thomas W. Elston, et al.
Publicado: (2018)