Association between CTLA-4 60G/A and -1661A/G polymorphisms and the risk of cancers: a meta-analysis.

<h4>Purpose</h4>CTLA-4 is one of the most fundamental immunosuppressive cotykines which belongs to the immunoglobulin super-family, and is expressed mainly on activated T cells. Previous studies have reported the existence of CTLA4 60G/A and CTLA4 -1661A/G polymorphism in cancers. Howeve...

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Autores principales:	Qing Yan, Pin Chen, Ailin Lu, Peng Zhao, Aihua Gu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/00c60e8d21aa4d028d7136a82423706e
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spelling	oai:doaj.org-article:00c60e8d21aa4d028d7136a82423706e2021-11-18T08:40:34ZAssociation between CTLA-4 60G/A and -1661A/G polymorphisms and the risk of cancers: a meta-analysis.1932-620310.1371/journal.pone.0083710https://doaj.org/article/00c60e8d21aa4d028d7136a82423706e2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24376736/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>CTLA-4 is one of the most fundamental immunosuppressive cotykines which belongs to the immunoglobulin super-family, and is expressed mainly on activated T cells. Previous studies have reported the existence of CTLA4 60G/A and CTLA4 -1661A/G polymorphism in cancers. However, the effects remain conflicting. Hence, we performed a meta-analysis to investigate the association between these polymorphisms and cancer risk.<h4>Methods</h4>We searched the Pubmed and Web of Science databases until October 24, 2013 to obtain relevant published studies. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the relationship between CTLA4 gene polymorphisms and cancer susceptibility were calculated by stata 11 software. Heterogeneity tests, sensitivity analyses and publication bias assessments were also performed in our meta-analysis.<h4>Results</h4>A total of 22 articles comprising 31 case-control studies concerning the CTLA-4 60G/A and CTLA-4 -1661A/G polymorphisms were included in the meta-analysis. The pooled results suggested the CTLA-4 60G/A polymorphism was significantly associated with an increased skin cancer risk (AA vs. GG: OR = 1.32, 95%CI = 1.09-1.59; AA vs. GA+GG: OR = 1.26, 95%CI = 1.07-1.48). For CTLA-4 -1661 A/G polymorphism, the results showed that the CTLA-4 -1661A/G polymorphism was significantly associated with an increased cancer risk (GA vs. AA: OR = 1.44, 95%CI = 1.13-1.82; GA+GG vs. AA: OR = 1.35, 95%CI = 1.07-1.69; G vs. A: OR = 1.21, 95%CI = 1.01-1.47), especially in gastric cancer, breast cancer, other cancers and in Asians population subgroups.<h4>Conclusion</h4>Our meta-analysis suggests that the CTLA-4 -1661A/G polymorphism is a potential factor for the susceptibility of cancer, especially in gastric cancer, breast cancer and other cancers, and the CTLA-4 60G/A polymorphism is significantly associated with increased skin cancer risk. The effect of the CTLA-4 -1661A/G polymorphism on cancer susceptibility especially exists in Asians and population based subjects.Qing YanPin ChenAilin LuPeng ZhaoAihua GuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83710 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qing Yan Pin Chen Ailin Lu Peng Zhao Aihua Gu Association between CTLA-4 60G/A and -1661A/G polymorphisms and the risk of cancers: a meta-analysis.
description	<h4>Purpose</h4>CTLA-4 is one of the most fundamental immunosuppressive cotykines which belongs to the immunoglobulin super-family, and is expressed mainly on activated T cells. Previous studies have reported the existence of CTLA4 60G/A and CTLA4 -1661A/G polymorphism in cancers. However, the effects remain conflicting. Hence, we performed a meta-analysis to investigate the association between these polymorphisms and cancer risk.<h4>Methods</h4>We searched the Pubmed and Web of Science databases until October 24, 2013 to obtain relevant published studies. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the relationship between CTLA4 gene polymorphisms and cancer susceptibility were calculated by stata 11 software. Heterogeneity tests, sensitivity analyses and publication bias assessments were also performed in our meta-analysis.<h4>Results</h4>A total of 22 articles comprising 31 case-control studies concerning the CTLA-4 60G/A and CTLA-4 -1661A/G polymorphisms were included in the meta-analysis. The pooled results suggested the CTLA-4 60G/A polymorphism was significantly associated with an increased skin cancer risk (AA vs. GG: OR = 1.32, 95%CI = 1.09-1.59; AA vs. GA+GG: OR = 1.26, 95%CI = 1.07-1.48). For CTLA-4 -1661 A/G polymorphism, the results showed that the CTLA-4 -1661A/G polymorphism was significantly associated with an increased cancer risk (GA vs. AA: OR = 1.44, 95%CI = 1.13-1.82; GA+GG vs. AA: OR = 1.35, 95%CI = 1.07-1.69; G vs. A: OR = 1.21, 95%CI = 1.01-1.47), especially in gastric cancer, breast cancer, other cancers and in Asians population subgroups.<h4>Conclusion</h4>Our meta-analysis suggests that the CTLA-4 -1661A/G polymorphism is a potential factor for the susceptibility of cancer, especially in gastric cancer, breast cancer and other cancers, and the CTLA-4 60G/A polymorphism is significantly associated with increased skin cancer risk. The effect of the CTLA-4 -1661A/G polymorphism on cancer susceptibility especially exists in Asians and population based subjects.
format	article
author	Qing Yan Pin Chen Ailin Lu Peng Zhao Aihua Gu
author_facet	Qing Yan Pin Chen Ailin Lu Peng Zhao Aihua Gu
author_sort	Qing Yan
title	Association between CTLA-4 60G/A and -1661A/G polymorphisms and the risk of cancers: a meta-analysis.
title_short	Association between CTLA-4 60G/A and -1661A/G polymorphisms and the risk of cancers: a meta-analysis.
title_full	Association between CTLA-4 60G/A and -1661A/G polymorphisms and the risk of cancers: a meta-analysis.
title_fullStr	Association between CTLA-4 60G/A and -1661A/G polymorphisms and the risk of cancers: a meta-analysis.
title_full_unstemmed	Association between CTLA-4 60G/A and -1661A/G polymorphisms and the risk of cancers: a meta-analysis.
title_sort	association between ctla-4 60g/a and -1661a/g polymorphisms and the risk of cancers: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/00c60e8d21aa4d028d7136a82423706e
work_keys_str_mv	AT qingyan associationbetweenctla460gaand1661agpolymorphismsandtheriskofcancersametaanalysis AT pinchen associationbetweenctla460gaand1661agpolymorphismsandtheriskofcancersametaanalysis AT ailinlu associationbetweenctla460gaand1661agpolymorphismsandtheriskofcancersametaanalysis AT pengzhao associationbetweenctla460gaand1661agpolymorphismsandtheriskofcancersametaanalysis AT aihuagu associationbetweenctla460gaand1661agpolymorphismsandtheriskofcancersametaanalysis
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Association between CTLA-4 60G/A and -1661A/G polymorphisms and the risk of cancers: a meta-analysis.

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