EVALUATION OF ENDOMETRIAL BIOPSIES FOR CHRONIC ENDOMETRITIS BY USING SYNDECAN-1 (CD138) IN ABNORMAL UTERINE BLEEDING

Objective: To determine the utility of Syndecan–1 (CD138) in the diagnosis of Chronic endometritis in patients with Abnormal Uterine Bleeding. Study Design: Cross-sectional study. Place and Duration: The study was carried out in department of Pathology, Army Medical College, Rawalpindi in coll...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aaminah Hanif, Tariq Sarfraz, Humaira Tariq, Saleem Ahmed Khan, Syed Raza Jaffar, Farhan Akhtar
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	abnormal uterine bleeding chronic endometritis plasma cell Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/00cdb95dd2904f3b97fe2e7fef31c138
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:00cdb95dd2904f3b97fe2e7fef31c138
record_format	dspace
spelling	oai:doaj.org-article:00cdb95dd2904f3b97fe2e7fef31c1382021-11-08T05:05:14ZEVALUATION OF ENDOMETRIAL BIOPSIES FOR CHRONIC ENDOMETRITIS BY USING SYNDECAN-1 (CD138) IN ABNORMAL UTERINE BLEEDING0030-96482411-8842https://doaj.org/article/00cdb95dd2904f3b97fe2e7fef31c1382019-12-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3662/2483https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the utility of Syndecan–1 (CD138) in the diagnosis of Chronic endometritis in patients with Abnormal Uterine Bleeding. Study Design: Cross-sectional study. Place and Duration: The study was carried out in department of Pathology, Army Medical College, Rawalpindi in collaboration with the department of Obstetrics & Gynecology, Pak Emirates Military Hospital (PEMH), Rawalpindi. The study duration was from Jan 2018 to Oct 2018. Methodology: A total of one hundred endometrial biopsies of patients with clinical or histological suspicion of chronic endometritis were taken. Hematoxylin and Eosin (H & E) stain was performed on all the biopsies and a diagnosis was made. Later on, Syndecan-1 was applied on all the biopsies and an immunohistochemical diagnosis was made. Both the diagnoses were then compared and analyzed. Results: Mean age of the study participants was 43.67 ± 8.95 years, with a range of 23-70 years. Out of 100 biopsies, forty-five cases (45%) were diagnosed as Chronic endometritis on H & E, while fifty-five cases (55%) were not showing Chronic endometritis and were diagnosed as disordered proliferative endometrium (DPE). On application of Syndecan-1 (CD 138), it was seen that these 19 out of 45 cases, diagnosed as Chronic endometritis on H & E were actually over-diagnosed and didn’t show plasma cells. Out of 55 cases which were negative for Chronic endometritis, 15 cases were underdiagnosed as they showed plasma cells with immunohistochemistry application (Syndecan-1). Conclusion: In cases suspected as Chronic endometritis, no plasma cells were clearly visible on H & E staining, Sydnecan-1 helps identifying plasma cells easily.Aaminah HanifTariq SarfrazHumaira TariqSaleem Ahmed KhanSyed Raza JaffarFarhan AkhtarArmy Medical College Rawalpindiarticleabnormal uterine bleedingchronic endometritisplasma cellMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 6, Pp 1341-1345 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	abnormal uterine bleeding chronic endometritis plasma cell Medicine R Medicine (General) R5-920
spellingShingle	abnormal uterine bleeding chronic endometritis plasma cell Medicine R Medicine (General) R5-920 Aaminah Hanif Tariq Sarfraz Humaira Tariq Saleem Ahmed Khan Syed Raza Jaffar Farhan Akhtar EVALUATION OF ENDOMETRIAL BIOPSIES FOR CHRONIC ENDOMETRITIS BY USING SYNDECAN-1 (CD138) IN ABNORMAL UTERINE BLEEDING
description	Objective: To determine the utility of Syndecan–1 (CD138) in the diagnosis of Chronic endometritis in patients with Abnormal Uterine Bleeding. Study Design: Cross-sectional study. Place and Duration: The study was carried out in department of Pathology, Army Medical College, Rawalpindi in collaboration with the department of Obstetrics & Gynecology, Pak Emirates Military Hospital (PEMH), Rawalpindi. The study duration was from Jan 2018 to Oct 2018. Methodology: A total of one hundred endometrial biopsies of patients with clinical or histological suspicion of chronic endometritis were taken. Hematoxylin and Eosin (H & E) stain was performed on all the biopsies and a diagnosis was made. Later on, Syndecan-1 was applied on all the biopsies and an immunohistochemical diagnosis was made. Both the diagnoses were then compared and analyzed. Results: Mean age of the study participants was 43.67 ± 8.95 years, with a range of 23-70 years. Out of 100 biopsies, forty-five cases (45%) were diagnosed as Chronic endometritis on H & E, while fifty-five cases (55%) were not showing Chronic endometritis and were diagnosed as disordered proliferative endometrium (DPE). On application of Syndecan-1 (CD 138), it was seen that these 19 out of 45 cases, diagnosed as Chronic endometritis on H & E were actually over-diagnosed and didn’t show plasma cells. Out of 55 cases which were negative for Chronic endometritis, 15 cases were underdiagnosed as they showed plasma cells with immunohistochemistry application (Syndecan-1). Conclusion: In cases suspected as Chronic endometritis, no plasma cells were clearly visible on H & E staining, Sydnecan-1 helps identifying plasma cells easily.
format	article
author	Aaminah Hanif Tariq Sarfraz Humaira Tariq Saleem Ahmed Khan Syed Raza Jaffar Farhan Akhtar
author_facet	Aaminah Hanif Tariq Sarfraz Humaira Tariq Saleem Ahmed Khan Syed Raza Jaffar Farhan Akhtar
author_sort	Aaminah Hanif
title	EVALUATION OF ENDOMETRIAL BIOPSIES FOR CHRONIC ENDOMETRITIS BY USING SYNDECAN-1 (CD138) IN ABNORMAL UTERINE BLEEDING
title_short	EVALUATION OF ENDOMETRIAL BIOPSIES FOR CHRONIC ENDOMETRITIS BY USING SYNDECAN-1 (CD138) IN ABNORMAL UTERINE BLEEDING
title_full	EVALUATION OF ENDOMETRIAL BIOPSIES FOR CHRONIC ENDOMETRITIS BY USING SYNDECAN-1 (CD138) IN ABNORMAL UTERINE BLEEDING
title_fullStr	EVALUATION OF ENDOMETRIAL BIOPSIES FOR CHRONIC ENDOMETRITIS BY USING SYNDECAN-1 (CD138) IN ABNORMAL UTERINE BLEEDING
title_full_unstemmed	EVALUATION OF ENDOMETRIAL BIOPSIES FOR CHRONIC ENDOMETRITIS BY USING SYNDECAN-1 (CD138) IN ABNORMAL UTERINE BLEEDING
title_sort	evaluation of endometrial biopsies for chronic endometritis by using syndecan-1 (cd138) in abnormal uterine bleeding
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/00cdb95dd2904f3b97fe2e7fef31c138
work_keys_str_mv	AT aaminahhanif evaluationofendometrialbiopsiesforchronicendometritisbyusingsyndecan1cd138inabnormaluterinebleeding AT tariqsarfraz evaluationofendometrialbiopsiesforchronicendometritisbyusingsyndecan1cd138inabnormaluterinebleeding AT humairatariq evaluationofendometrialbiopsiesforchronicendometritisbyusingsyndecan1cd138inabnormaluterinebleeding AT saleemahmedkhan evaluationofendometrialbiopsiesforchronicendometritisbyusingsyndecan1cd138inabnormaluterinebleeding AT syedrazajaffar evaluationofendometrialbiopsiesforchronicendometritisbyusingsyndecan1cd138inabnormaluterinebleeding AT farhanakhtar evaluationofendometrialbiopsiesforchronicendometritisbyusingsyndecan1cd138inabnormaluterinebleeding
_version_	1718442967942823936

EVALUATION OF ENDOMETRIAL BIOPSIES FOR CHRONIC ENDOMETRITIS BY USING SYNDECAN-1 (CD138) IN ABNORMAL UTERINE BLEEDING

Ejemplares similares