Laparoscopic sleeve gastrectomy alters 1H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease

Abstract Patients with morbid obesity frequently present non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) associated with pro-atherogenic alterations. Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for weight reduction, and for the remission of hepatic alter...

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Autores principales:	Noemí Cabré, Míriam Gil, Núria Amigó, Fedra Luciano-Mateo, Gerard Baiges-Gaya, Salvador Fernández-Arroyo, Elisabet Rodríguez-Tomàs, Anna Hernández-Aguilera, Helena Castañé, Marta París, Fàtima Sabench, Daniel Del Castillo, Jordi Camps, Jorge Joven
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/00d5ed34afc5481b88bbfce415760a21
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spelling	oai:doaj.org-article:00d5ed34afc5481b88bbfce415760a212021-12-02T14:12:47ZLaparoscopic sleeve gastrectomy alters 1H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease10.1038/s41598-020-79485-72045-2322https://doaj.org/article/00d5ed34afc5481b88bbfce415760a212021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79485-7https://doaj.org/toc/2045-2322Abstract Patients with morbid obesity frequently present non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) associated with pro-atherogenic alterations. Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for weight reduction, and for the remission of hepatic alterations. Using 1H-nuclear magnetic resonance (1H-NMR), we investigated the effects of LSG on lipoprotein and glycoprotein profile in patients with morbid obesity and liver disease. We included 154 patients with morbid obesity (49 non-NASH, 54 uncertain NASH, 51 definite NASH). A blood sample was obtained before surgery and, in patients with definite NASH, one year after surgery. Patients with NASH had increased concentrations of medium and small VLDL particles, VLDL and IDL cholesterol concentrations, IDL, LDL, and HDL triglyceride concentrations, and elevated glycoprotein levels. These changes were more marked in patients with type 2 diabetes mellitus. LSG produced significant decreases in the concentration of VLDL particles, VLDL cholesterol and triglycerides, an increase in the concentration LDL particles and LDL cholesterol concentrations, and a decrease in protein glycation. We conclude that patients with obesity and NASH had significant alterations in circulating levels of lipoproteins and glycoproteins that were associated with the severity of the disease. Most of these changes were reversed post-LSG.Noemí CabréMíriam GilNúria AmigóFedra Luciano-MateoGerard Baiges-GayaSalvador Fernández-ArroyoElisabet Rodríguez-TomàsAnna Hernández-AguileraHelena CastañéMarta ParísFàtima SabenchDaniel Del CastilloJordi CampsJorge JovenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Noemí Cabré Míriam Gil Núria Amigó Fedra Luciano-Mateo Gerard Baiges-Gaya Salvador Fernández-Arroyo Elisabet Rodríguez-Tomàs Anna Hernández-Aguilera Helena Castañé Marta París Fàtima Sabench Daniel Del Castillo Jordi Camps Jorge Joven Laparoscopic sleeve gastrectomy alters 1H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease
description	Abstract Patients with morbid obesity frequently present non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) associated with pro-atherogenic alterations. Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for weight reduction, and for the remission of hepatic alterations. Using 1H-nuclear magnetic resonance (1H-NMR), we investigated the effects of LSG on lipoprotein and glycoprotein profile in patients with morbid obesity and liver disease. We included 154 patients with morbid obesity (49 non-NASH, 54 uncertain NASH, 51 definite NASH). A blood sample was obtained before surgery and, in patients with definite NASH, one year after surgery. Patients with NASH had increased concentrations of medium and small VLDL particles, VLDL and IDL cholesterol concentrations, IDL, LDL, and HDL triglyceride concentrations, and elevated glycoprotein levels. These changes were more marked in patients with type 2 diabetes mellitus. LSG produced significant decreases in the concentration of VLDL particles, VLDL cholesterol and triglycerides, an increase in the concentration LDL particles and LDL cholesterol concentrations, and a decrease in protein glycation. We conclude that patients with obesity and NASH had significant alterations in circulating levels of lipoproteins and glycoproteins that were associated with the severity of the disease. Most of these changes were reversed post-LSG.
format	article
author	Noemí Cabré Míriam Gil Núria Amigó Fedra Luciano-Mateo Gerard Baiges-Gaya Salvador Fernández-Arroyo Elisabet Rodríguez-Tomàs Anna Hernández-Aguilera Helena Castañé Marta París Fàtima Sabench Daniel Del Castillo Jordi Camps Jorge Joven
author_facet	Noemí Cabré Míriam Gil Núria Amigó Fedra Luciano-Mateo Gerard Baiges-Gaya Salvador Fernández-Arroyo Elisabet Rodríguez-Tomàs Anna Hernández-Aguilera Helena Castañé Marta París Fàtima Sabench Daniel Del Castillo Jordi Camps Jorge Joven
author_sort	Noemí Cabré
title	Laparoscopic sleeve gastrectomy alters 1H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease
title_short	Laparoscopic sleeve gastrectomy alters 1H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease
title_full	Laparoscopic sleeve gastrectomy alters 1H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease
title_fullStr	Laparoscopic sleeve gastrectomy alters 1H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease
title_full_unstemmed	Laparoscopic sleeve gastrectomy alters 1H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease
title_sort	laparoscopic sleeve gastrectomy alters 1h-nmr-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/00d5ed34afc5481b88bbfce415760a21
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Laparoscopic sleeve gastrectomy alters 1H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease

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