Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence

The derivation of blood progenitor cells from human pluripotent stem cells is of interest for cell therapy but remains an inefficient process. Here the authors micropattern hPSC-derived haemogenic endothelial (HE) cells into spatially-organized, size-controlled colonies and identify a geometry that...

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Autores principales:	Nafees Rahman, Patrick M. Brauer, Lilian Ho, Tatiana Usenko, Mukul Tewary, Juan Carlos Zúñiga-Pflücker, Peter W. Zandstra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/00d82a9048724b09bcacb76efe643c61
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spelling	oai:doaj.org-article:00d82a9048724b09bcacb76efe643c612021-12-02T14:42:21ZEngineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence10.1038/ncomms153802041-1723https://doaj.org/article/00d82a9048724b09bcacb76efe643c612017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15380https://doaj.org/toc/2041-1723The derivation of blood progenitor cells from human pluripotent stem cells is of interest for cell therapy but remains an inefficient process. Here the authors micropattern hPSC-derived haemogenic endothelial (HE) cells into spatially-organized, size-controlled colonies and identify a geometry that achieves increased efficiency in deriving blood cells.Nafees RahmanPatrick M. BrauerLilian HoTatiana UsenkoMukul TewaryJuan Carlos Zúñiga-PflückerPeter W. ZandstraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nafees Rahman Patrick M. Brauer Lilian Ho Tatiana Usenko Mukul Tewary Juan Carlos Zúñiga-Pflücker Peter W. Zandstra Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence
description	The derivation of blood progenitor cells from human pluripotent stem cells is of interest for cell therapy but remains an inefficient process. Here the authors micropattern hPSC-derived haemogenic endothelial (HE) cells into spatially-organized, size-controlled colonies and identify a geometry that achieves increased efficiency in deriving blood cells.
format	article
author	Nafees Rahman Patrick M. Brauer Lilian Ho Tatiana Usenko Mukul Tewary Juan Carlos Zúñiga-Pflücker Peter W. Zandstra
author_facet	Nafees Rahman Patrick M. Brauer Lilian Ho Tatiana Usenko Mukul Tewary Juan Carlos Zúñiga-Pflücker Peter W. Zandstra
author_sort	Nafees Rahman
title	Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence
title_short	Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence
title_full	Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence
title_fullStr	Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence
title_full_unstemmed	Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence
title_sort	engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/00d82a9048724b09bcacb76efe643c61
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Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence

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