Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

Understanding the interaction between nanoparticles and biomolecules is crucial for improving current drug-delivery systems. Here, the authors shed light on the essential role of the surface and other physicochemical properties of a library of nanoparticles on their in vivo pharmacokinetics.

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Autores principales:	Nicolas Bertrand, Philippe Grenier, Morteza Mahmoudi, Eliana M. Lima, Eric A. Appel, Flavio Dormont, Jong-Min Lim, Rohit Karnik, Robert Langer, Omid C. Farokhzad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/00dc4fa9069d4166b50ad9376daec172
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spelling	oai:doaj.org-article:00dc4fa9069d4166b50ad9376daec1722021-12-02T16:51:47ZMechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics10.1038/s41467-017-00600-w2041-1723https://doaj.org/article/00dc4fa9069d4166b50ad9376daec1722017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00600-whttps://doaj.org/toc/2041-1723Understanding the interaction between nanoparticles and biomolecules is crucial for improving current drug-delivery systems. Here, the authors shed light on the essential role of the surface and other physicochemical properties of a library of nanoparticles on their in vivo pharmacokinetics.Nicolas BertrandPhilippe GrenierMorteza MahmoudiEliana M. LimaEric A. AppelFlavio DormontJong-Min LimRohit KarnikRobert LangerOmid C. FarokhzadNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicolas Bertrand Philippe Grenier Morteza Mahmoudi Eliana M. Lima Eric A. Appel Flavio Dormont Jong-Min Lim Rohit Karnik Robert Langer Omid C. Farokhzad Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics
description	Understanding the interaction between nanoparticles and biomolecules is crucial for improving current drug-delivery systems. Here, the authors shed light on the essential role of the surface and other physicochemical properties of a library of nanoparticles on their in vivo pharmacokinetics.
format	article
author	Nicolas Bertrand Philippe Grenier Morteza Mahmoudi Eliana M. Lima Eric A. Appel Flavio Dormont Jong-Min Lim Rohit Karnik Robert Langer Omid C. Farokhzad
author_facet	Nicolas Bertrand Philippe Grenier Morteza Mahmoudi Eliana M. Lima Eric A. Appel Flavio Dormont Jong-Min Lim Rohit Karnik Robert Langer Omid C. Farokhzad
author_sort	Nicolas Bertrand
title	Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics
title_short	Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics
title_full	Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics
title_fullStr	Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics
title_full_unstemmed	Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics
title_sort	mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/00dc4fa9069d4166b50ad9376daec172
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Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

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