An omics-based framework for assessing the health risk of antimicrobial resistance genes

Antibiotic resistance genes are common but not all are of high risk to human health. Here, the authors develop an omics-based framework for ranking genes by risk that incorporates level of enrichment in human associated environments, gene mobility, and host pathogenicity.

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Autores principales:	An-Ni Zhang, Jeffry M. Gaston, Chengzhen L. Dai, Shijie Zhao, Mathilde Poyet, Mathieu Groussin, Xiaole Yin, Li-Guan Li, Mark C. M. van Loosdrecht, Edward Topp, Michael R. Gillings, William P. Hanage, James M. Tiedje, Katya Moniz, Eric J. Alm, Tong Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/00e1d75466c746b5b7176e663387fb5b
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spelling	oai:doaj.org-article:00e1d75466c746b5b7176e663387fb5b2021-12-02T14:53:51ZAn omics-based framework for assessing the health risk of antimicrobial resistance genes10.1038/s41467-021-25096-32041-1723https://doaj.org/article/00e1d75466c746b5b7176e663387fb5b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25096-3https://doaj.org/toc/2041-1723Antibiotic resistance genes are common but not all are of high risk to human health. Here, the authors develop an omics-based framework for ranking genes by risk that incorporates level of enrichment in human associated environments, gene mobility, and host pathogenicity.An-Ni ZhangJeffry M. GastonChengzhen L. DaiShijie ZhaoMathilde PoyetMathieu GroussinXiaole YinLi-Guan LiMark C. M. van LoosdrechtEdward ToppMichael R. GillingsWilliam P. HanageJames M. TiedjeKatya MonizEric J. AlmTong ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q An-Ni Zhang Jeffry M. Gaston Chengzhen L. Dai Shijie Zhao Mathilde Poyet Mathieu Groussin Xiaole Yin Li-Guan Li Mark C. M. van Loosdrecht Edward Topp Michael R. Gillings William P. Hanage James M. Tiedje Katya Moniz Eric J. Alm Tong Zhang An omics-based framework for assessing the health risk of antimicrobial resistance genes
description	Antibiotic resistance genes are common but not all are of high risk to human health. Here, the authors develop an omics-based framework for ranking genes by risk that incorporates level of enrichment in human associated environments, gene mobility, and host pathogenicity.
format	article
author	An-Ni Zhang Jeffry M. Gaston Chengzhen L. Dai Shijie Zhao Mathilde Poyet Mathieu Groussin Xiaole Yin Li-Guan Li Mark C. M. van Loosdrecht Edward Topp Michael R. Gillings William P. Hanage James M. Tiedje Katya Moniz Eric J. Alm Tong Zhang
author_facet	An-Ni Zhang Jeffry M. Gaston Chengzhen L. Dai Shijie Zhao Mathilde Poyet Mathieu Groussin Xiaole Yin Li-Guan Li Mark C. M. van Loosdrecht Edward Topp Michael R. Gillings William P. Hanage James M. Tiedje Katya Moniz Eric J. Alm Tong Zhang
author_sort	An-Ni Zhang
title	An omics-based framework for assessing the health risk of antimicrobial resistance genes
title_short	An omics-based framework for assessing the health risk of antimicrobial resistance genes
title_full	An omics-based framework for assessing the health risk of antimicrobial resistance genes
title_fullStr	An omics-based framework for assessing the health risk of antimicrobial resistance genes
title_full_unstemmed	An omics-based framework for assessing the health risk of antimicrobial resistance genes
title_sort	omics-based framework for assessing the health risk of antimicrobial resistance genes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/00e1d75466c746b5b7176e663387fb5b
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An omics-based framework for assessing the health risk of antimicrobial resistance genes

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