Reliability and efficacy of maximum fluorescein tear break-up time in diagnosing dry eye disease

Abstract This study aims to investigate the reliability and efficacy of maximum fluorescein tear break-up time (FTBUTmax) in diagnosing dry eye disease (DED). 147 participants were enrolled in this study. Ocular symptoms were assessed by Ocular Surface Disease Index (OSDI). The fluorescein tear brea...

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Autores principales:	Yujie Mou, Huan Xiang, Lin Lin, Kelan Yuan, Xin Wang, Yaying Wu, Jinjin Min, Xiuming Jin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/00e34722c97f4f3b8c466b3f3c21cece
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spelling	oai:doaj.org-article:00e34722c97f4f3b8c466b3f3c21cece2021-12-02T15:57:12ZReliability and efficacy of maximum fluorescein tear break-up time in diagnosing dry eye disease10.1038/s41598-021-91110-92045-2322https://doaj.org/article/00e34722c97f4f3b8c466b3f3c21cece2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91110-9https://doaj.org/toc/2045-2322Abstract This study aims to investigate the reliability and efficacy of maximum fluorescein tear break-up time (FTBUTmax) in diagnosing dry eye disease (DED). 147 participants were enrolled in this study. Ocular symptoms were assessed by Ocular Surface Disease Index (OSDI). The fluorescein tear break-up time (FTBUT) examination, corneal fluorescein staining (CFS), and Schirmer I test were performed on both eyes. Each participant underwent 3 consecutive FTBUT tests, and five types of FTBUT values including FTBUTmax, the minimum FTBUT (FTBUTmin), the first FTBUT (FTBUT1), the average of three FTBUTs (FTBUT123) and the average of the first and second FTBUT (FTBUT12) were recorded. FTBUTmax was larger than the other FTBUT values, but no differences were found among the values of FTBUT1, FTBUT123, FTBUT12 and FTBUTmin. In the ROC analysis, FTBUTmax had the largest or the second largest area under the ROC (AUROC) in all three DED diagnostic criteria, while FTBUTmin had the least AUROC of them. ROC efficacy of FTBUTmax was significantly higher than that of FTBUT123, FTBUT12, FTBUT1 and FTBUTmin in the OSDI criteria and higher than that of FTBUT1 and FTBUTmin in Schirmer I test and CFS tests. FTBUTmax has a close correlation with OSDI, Schirmer I test and CFS, and is an effective tool for the DED diagnosis.Yujie MouHuan XiangLin LinKelan YuanXin WangYaying WuJinjin MinXiuming JinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yujie Mou Huan Xiang Lin Lin Kelan Yuan Xin Wang Yaying Wu Jinjin Min Xiuming Jin Reliability and efficacy of maximum fluorescein tear break-up time in diagnosing dry eye disease
description	Abstract This study aims to investigate the reliability and efficacy of maximum fluorescein tear break-up time (FTBUTmax) in diagnosing dry eye disease (DED). 147 participants were enrolled in this study. Ocular symptoms were assessed by Ocular Surface Disease Index (OSDI). The fluorescein tear break-up time (FTBUT) examination, corneal fluorescein staining (CFS), and Schirmer I test were performed on both eyes. Each participant underwent 3 consecutive FTBUT tests, and five types of FTBUT values including FTBUTmax, the minimum FTBUT (FTBUTmin), the first FTBUT (FTBUT1), the average of three FTBUTs (FTBUT123) and the average of the first and second FTBUT (FTBUT12) were recorded. FTBUTmax was larger than the other FTBUT values, but no differences were found among the values of FTBUT1, FTBUT123, FTBUT12 and FTBUTmin. In the ROC analysis, FTBUTmax had the largest or the second largest area under the ROC (AUROC) in all three DED diagnostic criteria, while FTBUTmin had the least AUROC of them. ROC efficacy of FTBUTmax was significantly higher than that of FTBUT123, FTBUT12, FTBUT1 and FTBUTmin in the OSDI criteria and higher than that of FTBUT1 and FTBUTmin in Schirmer I test and CFS tests. FTBUTmax has a close correlation with OSDI, Schirmer I test and CFS, and is an effective tool for the DED diagnosis.
format	article
author	Yujie Mou Huan Xiang Lin Lin Kelan Yuan Xin Wang Yaying Wu Jinjin Min Xiuming Jin
author_facet	Yujie Mou Huan Xiang Lin Lin Kelan Yuan Xin Wang Yaying Wu Jinjin Min Xiuming Jin
author_sort	Yujie Mou
title	Reliability and efficacy of maximum fluorescein tear break-up time in diagnosing dry eye disease
title_short	Reliability and efficacy of maximum fluorescein tear break-up time in diagnosing dry eye disease
title_full	Reliability and efficacy of maximum fluorescein tear break-up time in diagnosing dry eye disease
title_fullStr	Reliability and efficacy of maximum fluorescein tear break-up time in diagnosing dry eye disease
title_full_unstemmed	Reliability and efficacy of maximum fluorescein tear break-up time in diagnosing dry eye disease
title_sort	reliability and efficacy of maximum fluorescein tear break-up time in diagnosing dry eye disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/00e34722c97f4f3b8c466b3f3c21cece
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Reliability and efficacy of maximum fluorescein tear break-up time in diagnosing dry eye disease

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