Immuno-Potentiator Effect Of Rapeseed Or Soybean Oil With Foot And Mouth Disease Vaccine In Calves

One of the effective recommendation for control of Foot and Mouth disease virus is the proper vaccination by a highly potent vaccine. Such a vaccine should be specific to the circulated field serotype of foot and mouth disease virus inducing rapid, highly protective immunity with a long duration. Th...

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Autores principales:	Elsayed E. I., Mossad W.G., Ismail A.H., Shabana Walaa
Formato:	article
Lenguaje:	EN
Publicado:	Egyptian Society for Animal Management 2020
Materias:	fmd ginseng extract montanide oil 206 rapeseed oil soybean oil Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
Acceso en línea:	https://dx.doi.org/10.21608/javs.2020.103394 https://doaj.org/article/00e6251d4ee047b3a10c492e4a269277
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spelling	oai:doaj.org-article:00e6251d4ee047b3a10c492e4a2692772021-12-02T16:33:51ZImmuno-Potentiator Effect Of Rapeseed Or Soybean Oil With Foot And Mouth Disease Vaccine In Calveshttps://dx.doi.org/10.21608/javs.2020.1033941687-40722090-3308https://doaj.org/article/00e6251d4ee047b3a10c492e4a2692772020-07-01T00:00:00Zhttps://javs.journals.ekb.eg/article_103394.htmlhttps://doaj.org/toc/1687-4072https://doaj.org/toc/2090-3308One of the effective recommendation for control of Foot and Mouth disease virus is the proper vaccination by a highly potent vaccine. Such a vaccine should be specific to the circulated field serotype of foot and mouth disease virus inducing rapid, highly protective immunity with a long duration. This research is concerned with using plant extracted oil adjuvants prepared from rapeseed oil mixed with or without Ginseng extracts and from Soybean oil as well with or without Ginseng extracts. Some humoral and cellular immune responses were compared using the different plant-extracted oils and the mineral-based adjuvant called Montanide oil ISA 206 after one dose vaccination of the prepared vaccines at different interval times post vaccinations. Lymphocyte blastogenesis, Interleukin-6, and Interleukin-12 showed higher expression in calves vaccinated by FMDV serotypes (O pan Asia, A Iran O5, and SAT2 / EGY/2012) with plant extract oil containing Ginseng extract comparable to that of plant extracts without Ginseng and Montanide oil ISA 206 adjuvants vaccines. It was found that FMD vaccine adjuvant with ginseng either with rapeseed or Soybean showed a higher post vaccinal cellular immune response than that without ginseng or ISA 206 alone. Estimation of the humoral immune response of vaccinated calves revealed that antibody against FMD virus serotypes O pan Asia, A Iran O5 and SAT2 / EGY/2012 by SNT and ELISA assay induced by the inactivated FMD adjuvant with rapeseed oil and ginseng vaccine and the inactivated FMD adjuvant with soybean oil and ginseng vaccine were higher than those induced by inactivated FMD adjuvant with Montanide oils 206. In contrast, the obtained antibody levels by the inactivated FMD adjuvant with rapeseed oil vaccine and inactivated FMD adjuvant with soybean oil vaccine was lower than those induced by inactivated FMD adjuvant with Montanide oils 206. So, it could be concluded that the use of plant origin oil adjuvant as rapeseed and soybean oil is considered a beneficial and alternative adjuvant to the imported mineral oil as it is much cheaper and induce better post vaccinal immune responses especially when mixed with ginseng extract.Elsayed E. I.Mossad W.G.Ismail A.H. Shabana WalaaEgyptian Society for Animal Managementarticlefmdginseng extractmontanide oil 206rapeseed oilsoybean oilZoologyQL1-991Veterinary medicineSF600-1100Animal biochemistryQP501-801ENJournal of Applied Veterinary Sciences, Vol 5, Iss 3, Pp 92-102 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	fmd ginseng extract montanide oil 206 rapeseed oil soybean oil Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
spellingShingle	fmd ginseng extract montanide oil 206 rapeseed oil soybean oil Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801 Elsayed E. I. Mossad W.G. Ismail A.H. Shabana Walaa Immuno-Potentiator Effect Of Rapeseed Or Soybean Oil With Foot And Mouth Disease Vaccine In Calves
description	One of the effective recommendation for control of Foot and Mouth disease virus is the proper vaccination by a highly potent vaccine. Such a vaccine should be specific to the circulated field serotype of foot and mouth disease virus inducing rapid, highly protective immunity with a long duration. This research is concerned with using plant extracted oil adjuvants prepared from rapeseed oil mixed with or without Ginseng extracts and from Soybean oil as well with or without Ginseng extracts. Some humoral and cellular immune responses were compared using the different plant-extracted oils and the mineral-based adjuvant called Montanide oil ISA 206 after one dose vaccination of the prepared vaccines at different interval times post vaccinations. Lymphocyte blastogenesis, Interleukin-6, and Interleukin-12 showed higher expression in calves vaccinated by FMDV serotypes (O pan Asia, A Iran O5, and SAT2 / EGY/2012) with plant extract oil containing Ginseng extract comparable to that of plant extracts without Ginseng and Montanide oil ISA 206 adjuvants vaccines. It was found that FMD vaccine adjuvant with ginseng either with rapeseed or Soybean showed a higher post vaccinal cellular immune response than that without ginseng or ISA 206 alone. Estimation of the humoral immune response of vaccinated calves revealed that antibody against FMD virus serotypes O pan Asia, A Iran O5 and SAT2 / EGY/2012 by SNT and ELISA assay induced by the inactivated FMD adjuvant with rapeseed oil and ginseng vaccine and the inactivated FMD adjuvant with soybean oil and ginseng vaccine were higher than those induced by inactivated FMD adjuvant with Montanide oils 206. In contrast, the obtained antibody levels by the inactivated FMD adjuvant with rapeseed oil vaccine and inactivated FMD adjuvant with soybean oil vaccine was lower than those induced by inactivated FMD adjuvant with Montanide oils 206. So, it could be concluded that the use of plant origin oil adjuvant as rapeseed and soybean oil is considered a beneficial and alternative adjuvant to the imported mineral oil as it is much cheaper and induce better post vaccinal immune responses especially when mixed with ginseng extract.
format	article
author	Elsayed E. I. Mossad W.G. Ismail A.H. Shabana Walaa
author_facet	Elsayed E. I. Mossad W.G. Ismail A.H. Shabana Walaa
author_sort	Elsayed E. I.
title	Immuno-Potentiator Effect Of Rapeseed Or Soybean Oil With Foot And Mouth Disease Vaccine In Calves
title_short	Immuno-Potentiator Effect Of Rapeseed Or Soybean Oil With Foot And Mouth Disease Vaccine In Calves
title_full	Immuno-Potentiator Effect Of Rapeseed Or Soybean Oil With Foot And Mouth Disease Vaccine In Calves
title_fullStr	Immuno-Potentiator Effect Of Rapeseed Or Soybean Oil With Foot And Mouth Disease Vaccine In Calves
title_full_unstemmed	Immuno-Potentiator Effect Of Rapeseed Or Soybean Oil With Foot And Mouth Disease Vaccine In Calves
title_sort	immuno-potentiator effect of rapeseed or soybean oil with foot and mouth disease vaccine in calves
publisher	Egyptian Society for Animal Management
publishDate	2020
url	https://dx.doi.org/10.21608/javs.2020.103394 https://doaj.org/article/00e6251d4ee047b3a10c492e4a269277
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Immuno-Potentiator Effect Of Rapeseed Or Soybean Oil With Foot And Mouth Disease Vaccine In Calves

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