Photothermal therapy of cancer cells using novel hollow gold nanoflowers

Jing Han,1 Jinru Li,1 Wenfeng Jia,1 Liangming Yao,2 Xiaoqin Li,1 Long Jiang,1 Yong Tian21Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, 2Beijing Key Laboratory of Noncoding RNA, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of...

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Autores principales:	Han J, Li JR, Jia WF, Yao LM, Li XQ, Jiang L, Tian Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/00e6414937ae44d28e17eeac2c9ef6a9
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spelling	oai:doaj.org-article:00e6414937ae44d28e17eeac2c9ef6a92021-12-02T06:34:20ZPhotothermal therapy of cancer cells using novel hollow gold nanoflowers1178-2013https://doaj.org/article/00e6414937ae44d28e17eeac2c9ef6a92014-01-01T00:00:00Zhttp://www.dovepress.com/photothermal-therapy-of-cancer-cells-using-novel-hollow-gold-nanoflowe-a15535https://doaj.org/toc/1178-2013 Jing Han,1 Jinru Li,1 Wenfeng Jia,1 Liangming Yao,2 Xiaoqin Li,1 Long Jiang,1 Yong Tian21Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, 2Beijing Key Laboratory of Noncoding RNA, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of ChinaAbstract: This article presents a new strategy for fabricating large gold nanoflowers (AuNFs) that exhibit high biological safety under visible light and very strong photothermal cytotoxicity to HeLa cells under irradiation with near-infrared (NIR) light. This particular type of AuNF was constructed using vesicles produced from a multiamine head surfactant as a template followed by depositing gold nanoparticles (AuNPs) and growing their crystallites on the surface of vesicles. The localized surface plasmon-resonance spectrum of this type of AuNF can be easily modulated to the NIR region by controlling the size of the AuNFs. When the size of the AuNFs increased, biosafety under visible light improved and cytotoxicity increased under NIR irradiation. Experiments in vitro with HeLa cells and in vivo with small mice have been carried out, with promising results. The mechanism for this phenomenon is based on the hypothesis that it is difficult for larger AuNFs to enter the cell without NIR irradiation, but they enter the cell easily at the higher temperatures caused by NIR irradiation. We believe that these effects will exist in other types of noble metallic NPs and cancer cells. In addition, the affinity between AuNPs and functional biomolecules, such as aptamers and biomarkers, will make this type of AuNF a good recognition device in cancer diagnosis and therapy.Keywords: HeLa cells, endocytosis, cytotoxicity, AuNFs, NIR, cancer therapyHan JLi JRJia WFYao LMLi XQJiang LTian YDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 517-526 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Han J Li JR Jia WF Yao LM Li XQ Jiang L Tian Y Photothermal therapy of cancer cells using novel hollow gold nanoflowers
description	Jing Han,1 Jinru Li,1 Wenfeng Jia,1 Liangming Yao,2 Xiaoqin Li,1 Long Jiang,1 Yong Tian21Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, 2Beijing Key Laboratory of Noncoding RNA, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of ChinaAbstract: This article presents a new strategy for fabricating large gold nanoflowers (AuNFs) that exhibit high biological safety under visible light and very strong photothermal cytotoxicity to HeLa cells under irradiation with near-infrared (NIR) light. This particular type of AuNF was constructed using vesicles produced from a multiamine head surfactant as a template followed by depositing gold nanoparticles (AuNPs) and growing their crystallites on the surface of vesicles. The localized surface plasmon-resonance spectrum of this type of AuNF can be easily modulated to the NIR region by controlling the size of the AuNFs. When the size of the AuNFs increased, biosafety under visible light improved and cytotoxicity increased under NIR irradiation. Experiments in vitro with HeLa cells and in vivo with small mice have been carried out, with promising results. The mechanism for this phenomenon is based on the hypothesis that it is difficult for larger AuNFs to enter the cell without NIR irradiation, but they enter the cell easily at the higher temperatures caused by NIR irradiation. We believe that these effects will exist in other types of noble metallic NPs and cancer cells. In addition, the affinity between AuNPs and functional biomolecules, such as aptamers and biomarkers, will make this type of AuNF a good recognition device in cancer diagnosis and therapy.Keywords: HeLa cells, endocytosis, cytotoxicity, AuNFs, NIR, cancer therapy
format	article
author	Han J Li JR Jia WF Yao LM Li XQ Jiang L Tian Y
author_facet	Han J Li JR Jia WF Yao LM Li XQ Jiang L Tian Y
author_sort	Han J
title	Photothermal therapy of cancer cells using novel hollow gold nanoflowers
title_short	Photothermal therapy of cancer cells using novel hollow gold nanoflowers
title_full	Photothermal therapy of cancer cells using novel hollow gold nanoflowers
title_fullStr	Photothermal therapy of cancer cells using novel hollow gold nanoflowers
title_full_unstemmed	Photothermal therapy of cancer cells using novel hollow gold nanoflowers
title_sort	photothermal therapy of cancer cells using novel hollow gold nanoflowers
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/00e6414937ae44d28e17eeac2c9ef6a9
work_keys_str_mv	AT hanj photothermaltherapyofcancercellsusingnovelhollowgoldnanoflowers AT lijr photothermaltherapyofcancercellsusingnovelhollowgoldnanoflowers AT jiawf photothermaltherapyofcancercellsusingnovelhollowgoldnanoflowers AT yaolm photothermaltherapyofcancercellsusingnovelhollowgoldnanoflowers AT lixq photothermaltherapyofcancercellsusingnovelhollowgoldnanoflowers AT jiangl photothermaltherapyofcancercellsusingnovelhollowgoldnanoflowers AT tiany photothermaltherapyofcancercellsusingnovelhollowgoldnanoflowers
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Photothermal therapy of cancer cells using novel hollow gold nanoflowers

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