Cell polarity and cell adhesion associated gene expression differences between invasive micropapillary and no special type breast carcinomas and their prognostic significance

Abstract Invasive micropapillary carcinoma of the breast (IMPC) has been in the focus of several studies given its specific histology and clinicopathological course. We analysed mRNA expression profiles and the prognostic value of 43 genes involved in cell polarity, cell-adhesion and epithelial–mese...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zsófia Kramer, István Kenessey, Ambrus Gángó, Gábor Lendvai, Janina Kulka, Anna-Mária Tőkés
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/00e65620d0864be1bab4851c43dbba3b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:00e65620d0864be1bab4851c43dbba3b
record_format	dspace
spelling	oai:doaj.org-article:00e65620d0864be1bab4851c43dbba3b2021-12-02T15:15:35ZCell polarity and cell adhesion associated gene expression differences between invasive micropapillary and no special type breast carcinomas and their prognostic significance10.1038/s41598-021-97347-82045-2322https://doaj.org/article/00e65620d0864be1bab4851c43dbba3b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97347-8https://doaj.org/toc/2045-2322Abstract Invasive micropapillary carcinoma of the breast (IMPC) has been in the focus of several studies given its specific histology and clinicopathological course. We analysed mRNA expression profiles and the prognostic value of 43 genes involved in cell polarity, cell-adhesion and epithelial–mesenchymal transition (EMT) in IMPC tumors and compared them to invasive breast carcinomas of no special type (IBC-NST). IMPCs (36 cases), IBC-NSTs (36 cases) and mixed IMPC-IBC NSTs (8 cases) were investigated. mRNA expression level of selected genes were analysed using the NanoString nCounter Analysis System. Distant metastases free survival (DMFS) intervals were determined. Statistical analysis was performed using Statistica 13.5 software. Twelve genes showed significantly different expression in the IMPC group. There was no difference in DMFS according to histological type (IBC-NST vs. IMPC). High CLDN3, PALS1 and low PAR6 expression levels in the entire cohort were associated with shorter DMFS, and PALS1 was proven to be grade independent prognostic factor. Positive lymph node status was associated with higher levels of AKT1 expression. Differences in gene expression in IMPC versus IBC-NST may contribute to the unique histological appearance of IMPCs. No marked differences were observed in DMFS of the two groups. Altered gene expression in the mTOR signaling pathway in both tumor subtypes highlights the potential benefit from AKT/mTOR inhibitors in IMPCs similarly to IBC-NSTs.Zsófia KramerIstván KenesseyAmbrus GángóGábor LendvaiJanina KulkaAnna-Mária TőkésNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zsófia Kramer István Kenessey Ambrus Gángó Gábor Lendvai Janina Kulka Anna-Mária Tőkés Cell polarity and cell adhesion associated gene expression differences between invasive micropapillary and no special type breast carcinomas and their prognostic significance
description	Abstract Invasive micropapillary carcinoma of the breast (IMPC) has been in the focus of several studies given its specific histology and clinicopathological course. We analysed mRNA expression profiles and the prognostic value of 43 genes involved in cell polarity, cell-adhesion and epithelial–mesenchymal transition (EMT) in IMPC tumors and compared them to invasive breast carcinomas of no special type (IBC-NST). IMPCs (36 cases), IBC-NSTs (36 cases) and mixed IMPC-IBC NSTs (8 cases) were investigated. mRNA expression level of selected genes were analysed using the NanoString nCounter Analysis System. Distant metastases free survival (DMFS) intervals were determined. Statistical analysis was performed using Statistica 13.5 software. Twelve genes showed significantly different expression in the IMPC group. There was no difference in DMFS according to histological type (IBC-NST vs. IMPC). High CLDN3, PALS1 and low PAR6 expression levels in the entire cohort were associated with shorter DMFS, and PALS1 was proven to be grade independent prognostic factor. Positive lymph node status was associated with higher levels of AKT1 expression. Differences in gene expression in IMPC versus IBC-NST may contribute to the unique histological appearance of IMPCs. No marked differences were observed in DMFS of the two groups. Altered gene expression in the mTOR signaling pathway in both tumor subtypes highlights the potential benefit from AKT/mTOR inhibitors in IMPCs similarly to IBC-NSTs.
format	article
author	Zsófia Kramer István Kenessey Ambrus Gángó Gábor Lendvai Janina Kulka Anna-Mária Tőkés
author_facet	Zsófia Kramer István Kenessey Ambrus Gángó Gábor Lendvai Janina Kulka Anna-Mária Tőkés
author_sort	Zsófia Kramer
title	Cell polarity and cell adhesion associated gene expression differences between invasive micropapillary and no special type breast carcinomas and their prognostic significance
title_short	Cell polarity and cell adhesion associated gene expression differences between invasive micropapillary and no special type breast carcinomas and their prognostic significance
title_full	Cell polarity and cell adhesion associated gene expression differences between invasive micropapillary and no special type breast carcinomas and their prognostic significance
title_fullStr	Cell polarity and cell adhesion associated gene expression differences between invasive micropapillary and no special type breast carcinomas and their prognostic significance
title_full_unstemmed	Cell polarity and cell adhesion associated gene expression differences between invasive micropapillary and no special type breast carcinomas and their prognostic significance
title_sort	cell polarity and cell adhesion associated gene expression differences between invasive micropapillary and no special type breast carcinomas and their prognostic significance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/00e65620d0864be1bab4851c43dbba3b
work_keys_str_mv	AT zsofiakramer cellpolarityandcelladhesionassociatedgeneexpressiondifferencesbetweeninvasivemicropapillaryandnospecialtypebreastcarcinomasandtheirprognosticsignificance AT istvankenessey cellpolarityandcelladhesionassociatedgeneexpressiondifferencesbetweeninvasivemicropapillaryandnospecialtypebreastcarcinomasandtheirprognosticsignificance AT ambrusgango cellpolarityandcelladhesionassociatedgeneexpressiondifferencesbetweeninvasivemicropapillaryandnospecialtypebreastcarcinomasandtheirprognosticsignificance AT gaborlendvai cellpolarityandcelladhesionassociatedgeneexpressiondifferencesbetweeninvasivemicropapillaryandnospecialtypebreastcarcinomasandtheirprognosticsignificance AT janinakulka cellpolarityandcelladhesionassociatedgeneexpressiondifferencesbetweeninvasivemicropapillaryandnospecialtypebreastcarcinomasandtheirprognosticsignificance AT annamariatokes cellpolarityandcelladhesionassociatedgeneexpressiondifferencesbetweeninvasivemicropapillaryandnospecialtypebreastcarcinomasandtheirprognosticsignificance
_version_	1718387488210288640

Cell polarity and cell adhesion associated gene expression differences between invasive micropapillary and no special type breast carcinomas and their prognostic significance

Ejemplares similares