The usefulness of [18F]FDG-PET/CT in detecting and managing cancers with unknown primary site depends on histological subtype

Abstract We assessed the role of [18F]FDG-PET/CT in identifying and managing cancer of unknown primary site (CUP syndrome). We reviewed [18F]FDG-PET/CT scans of individuals with CUP syndrome recorded in clinical referral letters from 2012 to 2019. We evaluated the identification of primary tumor (PT...

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Autores principales:	Ella Nissan, Uri Amit, Leo Baron, Amit Zabatani, Damien Urban, Iris Barshack, Tima Davidson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/00e86c76594a42e5865e880486171661
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spelling	oai:doaj.org-article:00e86c76594a42e5865e8804861716612021-12-02T18:03:06ZThe usefulness of [18F]FDG-PET/CT in detecting and managing cancers with unknown primary site depends on histological subtype10.1038/s41598-021-96451-z2045-2322https://doaj.org/article/00e86c76594a42e5865e8804861716612021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96451-zhttps://doaj.org/toc/2045-2322Abstract We assessed the role of [18F]FDG-PET/CT in identifying and managing cancer of unknown primary site (CUP syndrome). We reviewed [18F]FDG-PET/CT scans of individuals with CUP syndrome recorded in clinical referral letters from 2012 to 2019. We evaluated the identification of primary tumor (PT) by [18F]FDG-PET/CT, according to histological subtype, and the impact on clinical management. The median age was 65 years, 36/64 males (56%). PTs were detected in 28/64 (44%) patients. Detection was significantly lower in patients with squamous cell carcinoma (SCC) than with other histologies combined, p = 0.034. Mean age, mean SUVmax (10.6 ± 6.0) and organ involvement were similar between patients with and without discovered PTs; and between patients with SCC and with other histologies combined. However, those with SCC were less likely than the others to present with multi-lesion involvement, p < 0.001. [18F]FDG-PET/CT interpretations apparently affected treatment of 8/28 (29%) patients with PT detected, and in none of the 35 whose PT was not discovered, p < 0.001. [18F]FDG-PET/CT appeared helpful in detecting PT in almost half the patients with CUP syndrome; the lowest rate was for patients with SCC pathology. PET/CT showed limited overall value in guiding clinical management, however benefited those with discovered PT.Ella NissanUri AmitLeo BaronAmit ZabataniDamien UrbanIris BarshackTima DavidsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ella Nissan Uri Amit Leo Baron Amit Zabatani Damien Urban Iris Barshack Tima Davidson The usefulness of [18F]FDG-PET/CT in detecting and managing cancers with unknown primary site depends on histological subtype
description	Abstract We assessed the role of [18F]FDG-PET/CT in identifying and managing cancer of unknown primary site (CUP syndrome). We reviewed [18F]FDG-PET/CT scans of individuals with CUP syndrome recorded in clinical referral letters from 2012 to 2019. We evaluated the identification of primary tumor (PT) by [18F]FDG-PET/CT, according to histological subtype, and the impact on clinical management. The median age was 65 years, 36/64 males (56%). PTs were detected in 28/64 (44%) patients. Detection was significantly lower in patients with squamous cell carcinoma (SCC) than with other histologies combined, p = 0.034. Mean age, mean SUVmax (10.6 ± 6.0) and organ involvement were similar between patients with and without discovered PTs; and between patients with SCC and with other histologies combined. However, those with SCC were less likely than the others to present with multi-lesion involvement, p < 0.001. [18F]FDG-PET/CT interpretations apparently affected treatment of 8/28 (29%) patients with PT detected, and in none of the 35 whose PT was not discovered, p < 0.001. [18F]FDG-PET/CT appeared helpful in detecting PT in almost half the patients with CUP syndrome; the lowest rate was for patients with SCC pathology. PET/CT showed limited overall value in guiding clinical management, however benefited those with discovered PT.
format	article
author	Ella Nissan Uri Amit Leo Baron Amit Zabatani Damien Urban Iris Barshack Tima Davidson
author_facet	Ella Nissan Uri Amit Leo Baron Amit Zabatani Damien Urban Iris Barshack Tima Davidson
author_sort	Ella Nissan
title	The usefulness of [18F]FDG-PET/CT in detecting and managing cancers with unknown primary site depends on histological subtype
title_short	The usefulness of [18F]FDG-PET/CT in detecting and managing cancers with unknown primary site depends on histological subtype
title_full	The usefulness of [18F]FDG-PET/CT in detecting and managing cancers with unknown primary site depends on histological subtype
title_fullStr	The usefulness of [18F]FDG-PET/CT in detecting and managing cancers with unknown primary site depends on histological subtype
title_full_unstemmed	The usefulness of [18F]FDG-PET/CT in detecting and managing cancers with unknown primary site depends on histological subtype
title_sort	usefulness of [18f]fdg-pet/ct in detecting and managing cancers with unknown primary site depends on histological subtype
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/00e86c76594a42e5865e880486171661
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The usefulness of [18F]FDG-PET/CT in detecting and managing cancers with unknown primary site depends on histological subtype

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