Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden
Liquid biopsies enable minimally invasive applications for diagnosis and treatment monitoring. Here the authors analyse fragmentation patterns of circulating tumour DNA on multiple levels and develop a bioinformatic tool, LIQUORICE, to accurately detect and classify paediatric cancers with low mutat...
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Nature Portfolio
2021
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oai:doaj.org-article:00ea02e3e86d482ea6b429b5132160112021-12-02T16:53:07ZMultimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden10.1038/s41467-021-23445-w2041-1723https://doaj.org/article/00ea02e3e86d482ea6b429b5132160112021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23445-whttps://doaj.org/toc/2041-1723Liquid biopsies enable minimally invasive applications for diagnosis and treatment monitoring. Here the authors analyse fragmentation patterns of circulating tumour DNA on multiple levels and develop a bioinformatic tool, LIQUORICE, to accurately detect and classify paediatric cancers with low mutational burden.Peter PenederAdrian M. StützDidier SurdezManuela KrumbholzSabine SemperMathieu ChicardNathan C. SheffieldGaelle PierronEve LapoubleMarcus TötzlBekir ErgünerDaniele BarrecaAndré F. RendeiroAbbas AgaimyHeidrun BoztugGernot EngstlerMichael DworzakMarie BernkopfSabine Taschner-MandlInge M. AmbrosOla MyklebostPerrine Marec-BérardSusan Ann BurchillBernadette BrennanSandra J. StraussJeremy WhelanGudrun SchleiermacherChristiane SchaeferUta DirksenCaroline HutterKjetil BoyePeter F. AmbrosOlivier DelattreMarkus MetzlerChristoph BockEleni M. TomazouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
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Science Q |
| spellingShingle |
Science Q Peter Peneder Adrian M. Stütz Didier Surdez Manuela Krumbholz Sabine Semper Mathieu Chicard Nathan C. Sheffield Gaelle Pierron Eve Lapouble Marcus Tötzl Bekir Ergüner Daniele Barreca André F. Rendeiro Abbas Agaimy Heidrun Boztug Gernot Engstler Michael Dworzak Marie Bernkopf Sabine Taschner-Mandl Inge M. Ambros Ola Myklebost Perrine Marec-Bérard Susan Ann Burchill Bernadette Brennan Sandra J. Strauss Jeremy Whelan Gudrun Schleiermacher Christiane Schaefer Uta Dirksen Caroline Hutter Kjetil Boye Peter F. Ambros Olivier Delattre Markus Metzler Christoph Bock Eleni M. Tomazou Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden |
| description |
Liquid biopsies enable minimally invasive applications for diagnosis and treatment monitoring. Here the authors analyse fragmentation patterns of circulating tumour DNA on multiple levels and develop a bioinformatic tool, LIQUORICE, to accurately detect and classify paediatric cancers with low mutational burden. |
| format |
article |
| author |
Peter Peneder Adrian M. Stütz Didier Surdez Manuela Krumbholz Sabine Semper Mathieu Chicard Nathan C. Sheffield Gaelle Pierron Eve Lapouble Marcus Tötzl Bekir Ergüner Daniele Barreca André F. Rendeiro Abbas Agaimy Heidrun Boztug Gernot Engstler Michael Dworzak Marie Bernkopf Sabine Taschner-Mandl Inge M. Ambros Ola Myklebost Perrine Marec-Bérard Susan Ann Burchill Bernadette Brennan Sandra J. Strauss Jeremy Whelan Gudrun Schleiermacher Christiane Schaefer Uta Dirksen Caroline Hutter Kjetil Boye Peter F. Ambros Olivier Delattre Markus Metzler Christoph Bock Eleni M. Tomazou |
| author_facet |
Peter Peneder Adrian M. Stütz Didier Surdez Manuela Krumbholz Sabine Semper Mathieu Chicard Nathan C. Sheffield Gaelle Pierron Eve Lapouble Marcus Tötzl Bekir Ergüner Daniele Barreca André F. Rendeiro Abbas Agaimy Heidrun Boztug Gernot Engstler Michael Dworzak Marie Bernkopf Sabine Taschner-Mandl Inge M. Ambros Ola Myklebost Perrine Marec-Bérard Susan Ann Burchill Bernadette Brennan Sandra J. Strauss Jeremy Whelan Gudrun Schleiermacher Christiane Schaefer Uta Dirksen Caroline Hutter Kjetil Boye Peter F. Ambros Olivier Delattre Markus Metzler Christoph Bock Eleni M. Tomazou |
| author_sort |
Peter Peneder |
| title |
Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden |
| title_short |
Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden |
| title_full |
Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden |
| title_fullStr |
Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden |
| title_full_unstemmed |
Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden |
| title_sort |
multimodal analysis of cell-free dna whole-genome sequencing for pediatric cancers with low mutational burden |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/00ea02e3e86d482ea6b429b513216011 |
| work_keys_str_mv |
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1718382838385999872 |