Influence of early stress on social abilities and serotonergic functions across generations in mice.

Exposure to adverse environments during early development is a known risk factor for several psychiatric conditions including antisocial behavior and personality disorders. Here, we induced social anxiety and altered social recognition memory in adult mice using unpredictable maternal separation and...

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Autores principales:	Tamara B Franklin, Natacha Linder, Holger Russig, Beat Thöny, Isabelle M Mansuy
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/00ec01f80e134f7995dcf01702f48f87
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spelling	oai:doaj.org-article:00ec01f80e134f7995dcf01702f48f872021-11-18T06:49:32ZInfluence of early stress on social abilities and serotonergic functions across generations in mice.1932-620310.1371/journal.pone.0021842https://doaj.org/article/00ec01f80e134f7995dcf01702f48f872011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21799751/?tool=EBIhttps://doaj.org/toc/1932-6203Exposure to adverse environments during early development is a known risk factor for several psychiatric conditions including antisocial behavior and personality disorders. Here, we induced social anxiety and altered social recognition memory in adult mice using unpredictable maternal separation and maternal stress during early postnatal life. We show that these social defects are not only pronounced in the animals directly subjected to stress, but are also transmitted to their offspring across two generations. The defects are associated with impaired serotonergic signaling, in particular, reduced 5HT1A receptor expression in the dorsal raphe nucleus, and increased serotonin level in a dorsal raphe projection area. These findings underscore the susceptibility of social behaviors and serotonergic pathways to early stress, and the persistence of their perturbation across generations.Tamara B FranklinNatacha LinderHolger RussigBeat ThönyIsabelle M MansuyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e21842 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tamara B Franklin Natacha Linder Holger Russig Beat Thöny Isabelle M Mansuy Influence of early stress on social abilities and serotonergic functions across generations in mice.
description	Exposure to adverse environments during early development is a known risk factor for several psychiatric conditions including antisocial behavior and personality disorders. Here, we induced social anxiety and altered social recognition memory in adult mice using unpredictable maternal separation and maternal stress during early postnatal life. We show that these social defects are not only pronounced in the animals directly subjected to stress, but are also transmitted to their offspring across two generations. The defects are associated with impaired serotonergic signaling, in particular, reduced 5HT1A receptor expression in the dorsal raphe nucleus, and increased serotonin level in a dorsal raphe projection area. These findings underscore the susceptibility of social behaviors and serotonergic pathways to early stress, and the persistence of their perturbation across generations.
format	article
author	Tamara B Franklin Natacha Linder Holger Russig Beat Thöny Isabelle M Mansuy
author_facet	Tamara B Franklin Natacha Linder Holger Russig Beat Thöny Isabelle M Mansuy
author_sort	Tamara B Franklin
title	Influence of early stress on social abilities and serotonergic functions across generations in mice.
title_short	Influence of early stress on social abilities and serotonergic functions across generations in mice.
title_full	Influence of early stress on social abilities and serotonergic functions across generations in mice.
title_fullStr	Influence of early stress on social abilities and serotonergic functions across generations in mice.
title_full_unstemmed	Influence of early stress on social abilities and serotonergic functions across generations in mice.
title_sort	influence of early stress on social abilities and serotonergic functions across generations in mice.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/00ec01f80e134f7995dcf01702f48f87
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Influence of early stress on social abilities and serotonergic functions across generations in mice.

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