Seasonal changes in nasal cytology in mite-allergic patients

Matteo Gelardi,1 Diego G Peroni,2 Cristoforo Incorvaia,3 Nicola Quaranta,1 Concetta De Luca,1 Salvatore Barberi,4 Ilaria Dell'Albani,5 Massimo Landi,6 Franco Frati,5 Olivier de Beaumont7 1Otolaryngology Unit, Department of Neuroscience and Sensory Organs, University of Bari, Bari, Italy; 2D...

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Autores principales:	Gelardi M, Peroni DG, Incorvaia C, Quaranta N, De Luca C, Barberi S, Dell'Albani I, Landi M, Frati F, de Beaumont O
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/00ec0644ba2d4c75998ed8e659b0e0bf
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spelling	oai:doaj.org-article:00ec0644ba2d4c75998ed8e659b0e0bf2021-12-02T01:20:32ZSeasonal changes in nasal cytology in mite-allergic patients1178-7031https://doaj.org/article/00ec0644ba2d4c75998ed8e659b0e0bf2014-03-01T00:00:00Zhttp://www.dovepress.com/seasonal-changes-in-nasal-cytology-in-mite-allergic-patients-a16075https://doaj.org/toc/1178-7031 Matteo Gelardi,1 Diego G Peroni,2 Cristoforo Incorvaia,3 Nicola Quaranta,1 Concetta De Luca,1 Salvatore Barberi,4 Ilaria Dell'Albani,5 Massimo Landi,6 Franco Frati,5 Olivier de Beaumont7 1Otolaryngology Unit, Department of Neuroscience and Sensory Organs, University of Bari, Bari, Italy; 2Department of Pediatrics, University of Verona, Verona, Italy; 3Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, Italy; 4Department of Pediatrics, San Paolo Hospital, Milan, Italy; 5Medical and Scientific Department, Stallergenes, Milan, Italy; 6Department of Pediatrics, National Healthcare System, ASL TO1, Turin, Italy; 7Medical Affairs Department, Stallergenes, Antony, France Background: House dust mites (HDMs) are a major cause of allergic rhinitis (AR) and asthma worldwide. Recent studies suggested that the allergen load presents seasonal modifications, giving rise to seasonal variation in nasal inflammation and symptoms. The aim of this study was to evaluate by nasal cytology whether nasal inflammation in mite-allergic patients changes with the seasons of the year. Methods: The study included 16 patients (seven males and nine females, mean age 38.1 years) with persistent AR caused by monosensitization to HDMs. Nasal cytology was performed in all patients once monthly for 1 year. Results: Nasal cytology showed that the cells most commonly detected in the nasal mucosa were neutrophils. During the period from October to April, a peak in the number of neutrophils and also the presence of significant numbers of eosinophils, mast cells, and lymphocytes/plasma cells were found, which shows the occurrence of more intense inflammation during these months. Conclusion: Nasal cytology provides useful data in detecting nasal inflammation and its association with the clinical stage of AR. The seasonal variations in nasal cytology are likely to be induced by the fluctuations in the HDM allergen that have been uncovered in recent investigations. Keywords: allergens, allergic rhinitis, house dust mite, nasal inflammationGelardi MPeroni DGIncorvaia CQuaranta NDe Luca CBarberi SDell'Albani ILandi MFrati Fde Beaumont ODove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2014, Iss default, Pp 39-44 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Gelardi M Peroni DG Incorvaia C Quaranta N De Luca C Barberi S Dell'Albani I Landi M Frati F de Beaumont O Seasonal changes in nasal cytology in mite-allergic patients
description	Matteo Gelardi,1 Diego G Peroni,2 Cristoforo Incorvaia,3 Nicola Quaranta,1 Concetta De Luca,1 Salvatore Barberi,4 Ilaria Dell'Albani,5 Massimo Landi,6 Franco Frati,5 Olivier de Beaumont7 1Otolaryngology Unit, Department of Neuroscience and Sensory Organs, University of Bari, Bari, Italy; 2Department of Pediatrics, University of Verona, Verona, Italy; 3Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, Italy; 4Department of Pediatrics, San Paolo Hospital, Milan, Italy; 5Medical and Scientific Department, Stallergenes, Milan, Italy; 6Department of Pediatrics, National Healthcare System, ASL TO1, Turin, Italy; 7Medical Affairs Department, Stallergenes, Antony, France Background: House dust mites (HDMs) are a major cause of allergic rhinitis (AR) and asthma worldwide. Recent studies suggested that the allergen load presents seasonal modifications, giving rise to seasonal variation in nasal inflammation and symptoms. The aim of this study was to evaluate by nasal cytology whether nasal inflammation in mite-allergic patients changes with the seasons of the year. Methods: The study included 16 patients (seven males and nine females, mean age 38.1 years) with persistent AR caused by monosensitization to HDMs. Nasal cytology was performed in all patients once monthly for 1 year. Results: Nasal cytology showed that the cells most commonly detected in the nasal mucosa were neutrophils. During the period from October to April, a peak in the number of neutrophils and also the presence of significant numbers of eosinophils, mast cells, and lymphocytes/plasma cells were found, which shows the occurrence of more intense inflammation during these months. Conclusion: Nasal cytology provides useful data in detecting nasal inflammation and its association with the clinical stage of AR. The seasonal variations in nasal cytology are likely to be induced by the fluctuations in the HDM allergen that have been uncovered in recent investigations. Keywords: allergens, allergic rhinitis, house dust mite, nasal inflammation
format	article
author	Gelardi M Peroni DG Incorvaia C Quaranta N De Luca C Barberi S Dell'Albani I Landi M Frati F de Beaumont O
author_facet	Gelardi M Peroni DG Incorvaia C Quaranta N De Luca C Barberi S Dell'Albani I Landi M Frati F de Beaumont O
author_sort	Gelardi M
title	Seasonal changes in nasal cytology in mite-allergic patients
title_short	Seasonal changes in nasal cytology in mite-allergic patients
title_full	Seasonal changes in nasal cytology in mite-allergic patients
title_fullStr	Seasonal changes in nasal cytology in mite-allergic patients
title_full_unstemmed	Seasonal changes in nasal cytology in mite-allergic patients
title_sort	seasonal changes in nasal cytology in mite-allergic patients
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/00ec0644ba2d4c75998ed8e659b0e0bf
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Seasonal changes in nasal cytology in mite-allergic patients

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