The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes

The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes

The p53 tumor suppressor is also a regulator of metabolism, but the mechanisms controlling p53-associated metabolic activities remain poorly understood. Here the authors report that the deletion of the multifunctional protein E4F1 is protective against diet-induced obesity in mice, and E4F1 regulate...

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Autores principales: Matthieu Lacroix, Laetitia K. Linares, Natalia Rueda-Rincon, Katarzyna Bloch, Michela Di Michele, Carlo De Blasio, Caroline Fau, Laurie Gayte, Emilie Blanchet, Aline Mairal, Rita Derua, Fernando Cardona, Diane Beuzelin, Jean-Sebastien Annicotte, Nelly Pirot, Adeline Torro, Francisco J. Tinahones, Florence Bernex, Justine Bertrand-Michel, Dominique Langin, Lluis Fajas, Johannes V. Swinnen, Laurent Le Cam
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/00ec515c8ba444a682cea51127843aeb
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spelling oai:doaj.org-article:00ec515c8ba444a682cea51127843aeb2021-12-05T12:21:56ZThe multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes10.1038/s41467-021-27307-32041-1723https://doaj.org/article/00ec515c8ba444a682cea51127843aeb2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27307-3https://doaj.org/toc/2041-1723The p53 tumor suppressor is also a regulator of metabolism, but the mechanisms controlling p53-associated metabolic activities remain poorly understood. Here the authors report that the deletion of the multifunctional protein E4F1 is protective against diet-induced obesity in mice, and E4F1 regulates adipocyte lipid metabolism through p53.Matthieu LacroixLaetitia K. LinaresNatalia Rueda-RinconKatarzyna BlochMichela Di MicheleCarlo De BlasioCaroline FauLaurie GayteEmilie BlanchetAline MairalRita DeruaFernando CardonaDiane BeuzelinJean-Sebastien AnnicotteNelly PirotAdeline TorroFrancisco J. TinahonesFlorence BernexJustine Bertrand-MichelDominique LanginLluis FajasJohannes V. SwinnenLaurent Le CamNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Matthieu Lacroix
Laetitia K. Linares
Natalia Rueda-Rincon
Katarzyna Bloch
Michela Di Michele
Carlo De Blasio
Caroline Fau
Laurie Gayte
Emilie Blanchet
Aline Mairal
Rita Derua
Fernando Cardona
Diane Beuzelin
Jean-Sebastien Annicotte
Nelly Pirot
Adeline Torro
Francisco J. Tinahones
Florence Bernex
Justine Bertrand-Michel
Dominique Langin
Lluis Fajas
Johannes V. Swinnen
Laurent Le Cam
The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes
description The p53 tumor suppressor is also a regulator of metabolism, but the mechanisms controlling p53-associated metabolic activities remain poorly understood. Here the authors report that the deletion of the multifunctional protein E4F1 is protective against diet-induced obesity in mice, and E4F1 regulates adipocyte lipid metabolism through p53.
format article
author Matthieu Lacroix
Laetitia K. Linares
Natalia Rueda-Rincon
Katarzyna Bloch
Michela Di Michele
Carlo De Blasio
Caroline Fau
Laurie Gayte
Emilie Blanchet
Aline Mairal
Rita Derua
Fernando Cardona
Diane Beuzelin
Jean-Sebastien Annicotte
Nelly Pirot
Adeline Torro
Francisco J. Tinahones
Florence Bernex
Justine Bertrand-Michel
Dominique Langin
Lluis Fajas
Johannes V. Swinnen
Laurent Le Cam
author_facet Matthieu Lacroix
Laetitia K. Linares
Natalia Rueda-Rincon
Katarzyna Bloch
Michela Di Michele
Carlo De Blasio
Caroline Fau
Laurie Gayte
Emilie Blanchet
Aline Mairal
Rita Derua
Fernando Cardona
Diane Beuzelin
Jean-Sebastien Annicotte
Nelly Pirot
Adeline Torro
Francisco J. Tinahones
Florence Bernex
Justine Bertrand-Michel
Dominique Langin
Lluis Fajas
Johannes V. Swinnen
Laurent Le Cam
author_sort Matthieu Lacroix
title The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes
title_short The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes
title_full The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes
title_fullStr The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes
title_full_unstemmed The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes
title_sort multifunctional protein e4f1 links p53 to lipid metabolism in adipocytes
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/00ec515c8ba444a682cea51127843aeb
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