Tissue sodium excess is not hypertonic and reflects extracellular volume expansion

Na+ has been suggested to accumulate in tissues, particularly skin, in a hypertonic manner and to exert local pathogenic effects. Here, we reappraise this phenomenon which is systemic in nature and reflects isotonic changes in the relative extracellular volume in tissues, e.g. subclinical oedema; as...

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Autores principales:	Giacomo Rossitto, Sheon Mary, Jun Yu Chen, Philipp Boder, Khai Syuen Chew, Karla B. Neves, Rheure L. Alves, Augusto C. Montezano, Paul Welsh, Mark C. Petrie, Delyth Graham, Rhian M. Touyz, Christian Delles
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/00f4143ef72e4165a258bfd5a79eca0e
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spelling	oai:doaj.org-article:00f4143ef72e4165a258bfd5a79eca0e2021-12-02T19:02:28ZTissue sodium excess is not hypertonic and reflects extracellular volume expansion10.1038/s41467-020-17820-22041-1723https://doaj.org/article/00f4143ef72e4165a258bfd5a79eca0e2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17820-2https://doaj.org/toc/2041-1723Na+ has been suggested to accumulate in tissues, particularly skin, in a hypertonic manner and to exert local pathogenic effects. Here, we reappraise this phenomenon which is systemic in nature and reflects isotonic changes in the relative extracellular volume in tissues, e.g. subclinical oedema; as such, it occurs in human hypertension and aging.Giacomo RossittoSheon MaryJun Yu ChenPhilipp BoderKhai Syuen ChewKarla B. NevesRheure L. AlvesAugusto C. MontezanoPaul WelshMark C. PetrieDelyth GrahamRhian M. TouyzChristian DellesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giacomo Rossitto Sheon Mary Jun Yu Chen Philipp Boder Khai Syuen Chew Karla B. Neves Rheure L. Alves Augusto C. Montezano Paul Welsh Mark C. Petrie Delyth Graham Rhian M. Touyz Christian Delles Tissue sodium excess is not hypertonic and reflects extracellular volume expansion
description	Na+ has been suggested to accumulate in tissues, particularly skin, in a hypertonic manner and to exert local pathogenic effects. Here, we reappraise this phenomenon which is systemic in nature and reflects isotonic changes in the relative extracellular volume in tissues, e.g. subclinical oedema; as such, it occurs in human hypertension and aging.
format	article
author	Giacomo Rossitto Sheon Mary Jun Yu Chen Philipp Boder Khai Syuen Chew Karla B. Neves Rheure L. Alves Augusto C. Montezano Paul Welsh Mark C. Petrie Delyth Graham Rhian M. Touyz Christian Delles
author_facet	Giacomo Rossitto Sheon Mary Jun Yu Chen Philipp Boder Khai Syuen Chew Karla B. Neves Rheure L. Alves Augusto C. Montezano Paul Welsh Mark C. Petrie Delyth Graham Rhian M. Touyz Christian Delles
author_sort	Giacomo Rossitto
title	Tissue sodium excess is not hypertonic and reflects extracellular volume expansion
title_short	Tissue sodium excess is not hypertonic and reflects extracellular volume expansion
title_full	Tissue sodium excess is not hypertonic and reflects extracellular volume expansion
title_fullStr	Tissue sodium excess is not hypertonic and reflects extracellular volume expansion
title_full_unstemmed	Tissue sodium excess is not hypertonic and reflects extracellular volume expansion
title_sort	tissue sodium excess is not hypertonic and reflects extracellular volume expansion
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/00f4143ef72e4165a258bfd5a79eca0e
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Tissue sodium excess is not hypertonic and reflects extracellular volume expansion

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