Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors
The heterogeneity of colorectal cancer has important clinical and therapeutic implications. Here the authors analysed the responses of a large biobank of organoids and xenografts derived from colorectal patients to a panel of clinically relevant therapeutic agents to identify genes signatures associ...
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Nature Portfolio
2017
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oai:doaj.org-article:00f477ba693042c6918f1164e120c8e42021-12-02T15:36:59ZMolecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors10.1038/ncomms142622041-1723https://doaj.org/article/00f477ba693042c6918f1164e120c8e42017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14262https://doaj.org/toc/2041-1723The heterogeneity of colorectal cancer has important clinical and therapeutic implications. Here the authors analysed the responses of a large biobank of organoids and xenografts derived from colorectal patients to a panel of clinically relevant therapeutic agents to identify genes signatures associated with drug response.Moritz SchütteThomas RischNilofar Abdavi-AzarKarsten BoehnkeDirk SchumacherMarlen KeilReha YildirimanChristine JandrasitsTatiana BorodinaVyacheslav AmstislavskiyCatherine L. WorthCaroline SchweigerSandra LiebsMartin LangeHans- Jörg WarnatzLee M. ButcherJames E. BarrettMarc SultanChristoph WierlingNicole Golob-SchwarzlSigurd LaxStefan UranitschMichael BeckerYvonne WelteJoseph Lewis ReganMaxine SilvestrovInge KehlerAlberto FusiThomas KesslerRalf HerwigUlf LandegrenDirk WienkeMats NilssonJuan A. VelascoPilar Garin-ChesaChristoph ReinhardStephan BeckReinhold SchäferChristian R. A. RegenbrechtDavid HendersonBodo LangeJohannes HaybaeckUlrich KeilholzJens HoffmannHans LehrachMarie-Laure YaspoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-19 (2017) |
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DOAJ |
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Science Q Moritz Schütte Thomas Risch Nilofar Abdavi-Azar Karsten Boehnke Dirk Schumacher Marlen Keil Reha Yildiriman Christine Jandrasits Tatiana Borodina Vyacheslav Amstislavskiy Catherine L. Worth Caroline Schweiger Sandra Liebs Martin Lange Hans- Jörg Warnatz Lee M. Butcher James E. Barrett Marc Sultan Christoph Wierling Nicole Golob-Schwarzl Sigurd Lax Stefan Uranitsch Michael Becker Yvonne Welte Joseph Lewis Regan Maxine Silvestrov Inge Kehler Alberto Fusi Thomas Kessler Ralf Herwig Ulf Landegren Dirk Wienke Mats Nilsson Juan A. Velasco Pilar Garin-Chesa Christoph Reinhard Stephan Beck Reinhold Schäfer Christian R. A. Regenbrecht David Henderson Bodo Lange Johannes Haybaeck Ulrich Keilholz Jens Hoffmann Hans Lehrach Marie-Laure Yaspo Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors |
| description |
The heterogeneity of colorectal cancer has important clinical and therapeutic implications. Here the authors analysed the responses of a large biobank of organoids and xenografts derived from colorectal patients to a panel of clinically relevant therapeutic agents to identify genes signatures associated with drug response. |
| format |
article |
| author |
Moritz Schütte Thomas Risch Nilofar Abdavi-Azar Karsten Boehnke Dirk Schumacher Marlen Keil Reha Yildiriman Christine Jandrasits Tatiana Borodina Vyacheslav Amstislavskiy Catherine L. Worth Caroline Schweiger Sandra Liebs Martin Lange Hans- Jörg Warnatz Lee M. Butcher James E. Barrett Marc Sultan Christoph Wierling Nicole Golob-Schwarzl Sigurd Lax Stefan Uranitsch Michael Becker Yvonne Welte Joseph Lewis Regan Maxine Silvestrov Inge Kehler Alberto Fusi Thomas Kessler Ralf Herwig Ulf Landegren Dirk Wienke Mats Nilsson Juan A. Velasco Pilar Garin-Chesa Christoph Reinhard Stephan Beck Reinhold Schäfer Christian R. A. Regenbrecht David Henderson Bodo Lange Johannes Haybaeck Ulrich Keilholz Jens Hoffmann Hans Lehrach Marie-Laure Yaspo |
| author_facet |
Moritz Schütte Thomas Risch Nilofar Abdavi-Azar Karsten Boehnke Dirk Schumacher Marlen Keil Reha Yildiriman Christine Jandrasits Tatiana Borodina Vyacheslav Amstislavskiy Catherine L. Worth Caroline Schweiger Sandra Liebs Martin Lange Hans- Jörg Warnatz Lee M. Butcher James E. Barrett Marc Sultan Christoph Wierling Nicole Golob-Schwarzl Sigurd Lax Stefan Uranitsch Michael Becker Yvonne Welte Joseph Lewis Regan Maxine Silvestrov Inge Kehler Alberto Fusi Thomas Kessler Ralf Herwig Ulf Landegren Dirk Wienke Mats Nilsson Juan A. Velasco Pilar Garin-Chesa Christoph Reinhard Stephan Beck Reinhold Schäfer Christian R. A. Regenbrecht David Henderson Bodo Lange Johannes Haybaeck Ulrich Keilholz Jens Hoffmann Hans Lehrach Marie-Laure Yaspo |
| author_sort |
Moritz Schütte |
| title |
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors |
| title_short |
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors |
| title_full |
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors |
| title_fullStr |
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors |
| title_full_unstemmed |
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors |
| title_sort |
molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to egfr inhibitors |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/00f477ba693042c6918f1164e120c8e4 |
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