Artesunate prevents rats from the clozapine-induced hepatic steatosis and elevation in plasma triglycerides

Yanmei Li,1,2 Ruibing Su,3 Shuqin Xu,2 Qingjun Huang,1 Haiyun Xu1,2 1The Mental Health Center, Shantou University Medical College, Shantou, Guangdong Province, People’s Republic of China; 2Department of Anatomy, Shantou University Medical College, Shantou, Guangdong Province, People&r...

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Autores principales:	Li Y, Su R, Xu S, Huang Q, Xu H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	artesunate clozapine dyslipidemia hepatic steatosis schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/00f4e20abf4e4f0bba65699f5cbe0aa7
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spelling	oai:doaj.org-article:00f4e20abf4e4f0bba65699f5cbe0aa72021-12-02T00:27:54ZArtesunate prevents rats from the clozapine-induced hepatic steatosis and elevation in plasma triglycerides1178-2021https://doaj.org/article/00f4e20abf4e4f0bba65699f5cbe0aa72017-09-01T00:00:00Zhttps://www.dovepress.com/artesunate-prevents-rats-from-the-clozapine-induced-hepatic-steatosis--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yanmei Li,1,2 Ruibing Su,3 Shuqin Xu,2 Qingjun Huang,1 Haiyun Xu1,2 1The Mental Health Center, Shantou University Medical College, Shantou, Guangdong Province, People’s Republic of China; 2Department of Anatomy, Shantou University Medical College, Shantou, Guangdong Province, People’s Republic of China; 3Department of Forensics and Pathology, Shantou University Medical College, Shantou, Guangdong Province, People’s Republic of China Abstract: Clozapine is an atypical antipsychotic with therapeutic efficacy in treatment-resistant schizophrenia patients and low incidence of extrapyramidal side effects. However, the use of clozapine has been limited by its adverse effects on metabolism. Artesunate is a semisynthetic derivative of artemisinin and was shown to decrease the plasma cholesterol and triglyceride in rabbits and rats in recent studies. The aim of this study was to examine possible effects of artesunate on the clozapine-induced metabolic alterations in rats given saline, clozapine, artesunate, or clozapine plus artesunate for 6 weeks. The clozapine group showed significantly high plasma levels of triglyceride, hepatic steatosis, and fibrosis along with high levels of C-reactive protein, alanine aminotransferase, and aspartate aminotransferase compared to the saline group. But the treatment had no effect on weight gain and caused no hyperglycemia, hyperinsulinemia, and behavioral changes in the rats. More significantly, these clozapine-induced changes were not seen in rats coadministered with clozapine plus artesunate. These results added evidence supporting psychiatrists to try add-on treatment of artesunate in schizophrenia patients to ameliorate clozapine-induced adverse metabolic effects. Keywords: artesunate, clozapine, dyslipidemia, hepatic steatosis, schizophrenia Li YSu RXu SHuang QXu HDove Medical Pressarticleartesunateclozapinedyslipidemiahepatic steatosisschizophreniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2477-2487 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	artesunate clozapine dyslipidemia hepatic steatosis schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	artesunate clozapine dyslipidemia hepatic steatosis schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Li Y Su R Xu S Huang Q Xu H Artesunate prevents rats from the clozapine-induced hepatic steatosis and elevation in plasma triglycerides
description	Yanmei Li,1,2 Ruibing Su,3 Shuqin Xu,2 Qingjun Huang,1 Haiyun Xu1,2 1The Mental Health Center, Shantou University Medical College, Shantou, Guangdong Province, People’s Republic of China; 2Department of Anatomy, Shantou University Medical College, Shantou, Guangdong Province, People’s Republic of China; 3Department of Forensics and Pathology, Shantou University Medical College, Shantou, Guangdong Province, People’s Republic of China Abstract: Clozapine is an atypical antipsychotic with therapeutic efficacy in treatment-resistant schizophrenia patients and low incidence of extrapyramidal side effects. However, the use of clozapine has been limited by its adverse effects on metabolism. Artesunate is a semisynthetic derivative of artemisinin and was shown to decrease the plasma cholesterol and triglyceride in rabbits and rats in recent studies. The aim of this study was to examine possible effects of artesunate on the clozapine-induced metabolic alterations in rats given saline, clozapine, artesunate, or clozapine plus artesunate for 6 weeks. The clozapine group showed significantly high plasma levels of triglyceride, hepatic steatosis, and fibrosis along with high levels of C-reactive protein, alanine aminotransferase, and aspartate aminotransferase compared to the saline group. But the treatment had no effect on weight gain and caused no hyperglycemia, hyperinsulinemia, and behavioral changes in the rats. More significantly, these clozapine-induced changes were not seen in rats coadministered with clozapine plus artesunate. These results added evidence supporting psychiatrists to try add-on treatment of artesunate in schizophrenia patients to ameliorate clozapine-induced adverse metabolic effects. Keywords: artesunate, clozapine, dyslipidemia, hepatic steatosis, schizophrenia
format	article
author	Li Y Su R Xu S Huang Q Xu H
author_facet	Li Y Su R Xu S Huang Q Xu H
author_sort	Li Y
title	Artesunate prevents rats from the clozapine-induced hepatic steatosis and elevation in plasma triglycerides
title_short	Artesunate prevents rats from the clozapine-induced hepatic steatosis and elevation in plasma triglycerides
title_full	Artesunate prevents rats from the clozapine-induced hepatic steatosis and elevation in plasma triglycerides
title_fullStr	Artesunate prevents rats from the clozapine-induced hepatic steatosis and elevation in plasma triglycerides
title_full_unstemmed	Artesunate prevents rats from the clozapine-induced hepatic steatosis and elevation in plasma triglycerides
title_sort	artesunate prevents rats from the clozapine-induced hepatic steatosis and elevation in plasma triglycerides
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/00f4e20abf4e4f0bba65699f5cbe0aa7
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Artesunate prevents rats from the clozapine-induced hepatic steatosis and elevation in plasma triglycerides

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