Diagnostic, Predictive, and Prognostic Biomarkers in Non-Small Cell Lung Cancer (NSCLC) Management

Lung cancer is the leading cause of cancer-related deaths worldwide. Despite growing efforts for its early detection by screening populations at risk, the majority of lung cancer patients are still diagnosed in an advanced stage. The management of lung cancer has dramatically improved in the last de...

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Autores principales:	Maja Šutić, Ana Vukić, Jurica Baranašić, Asta Försti, Feđa Džubur, Miroslav Samaržija, Marko Jakopović, Luka Brčić, Jelena Knežević
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	lung cancer adenocarcinoma squamous cell lung cancer biomarker diagnosis prognosis Medicine R
Acceso en línea:	https://doaj.org/article/00f9bdc3beec41cc9b5219b955f161b9
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spelling	oai:doaj.org-article:00f9bdc3beec41cc9b5219b955f161b92021-11-25T18:07:12ZDiagnostic, Predictive, and Prognostic Biomarkers in Non-Small Cell Lung Cancer (NSCLC) Management10.3390/jpm111111022075-4426https://doaj.org/article/00f9bdc3beec41cc9b5219b955f161b92021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1102https://doaj.org/toc/2075-4426Lung cancer is the leading cause of cancer-related deaths worldwide. Despite growing efforts for its early detection by screening populations at risk, the majority of lung cancer patients are still diagnosed in an advanced stage. The management of lung cancer has dramatically improved in the last decade and is no longer based on the “one-fits-all” paradigm or the general histological classification of non-small cell versus small cell lung cancer. Emerging options of targeted therapies and immunotherapies have shifted the management of lung cancer to a more personalized treatment approach, significantly influencing the clinical course and outcome of the disease. Molecular biomarkers have emerged as valuable tools in the prognosis and prediction of therapy response. In this review, we discuss the relevant biomarkers used in the clinical management of lung tumors, from diagnosis to prognosis. We also discuss promising new biomarkers, focusing on non-small cell lung cancer as the most abundant type of lung cancer.Maja ŠutićAna VukićJurica BaranašićAsta FörstiFeđa DžuburMiroslav SamaržijaMarko JakopovićLuka BrčićJelena KneževićMDPI AGarticlelung canceradenocarcinomasquamous cell lung cancerbiomarkerdiagnosisprognosisMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1102, p 1102 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung cancer adenocarcinoma squamous cell lung cancer biomarker diagnosis prognosis Medicine R
spellingShingle	lung cancer adenocarcinoma squamous cell lung cancer biomarker diagnosis prognosis Medicine R Maja Šutić Ana Vukić Jurica Baranašić Asta Försti Feđa Džubur Miroslav Samaržija Marko Jakopović Luka Brčić Jelena Knežević Diagnostic, Predictive, and Prognostic Biomarkers in Non-Small Cell Lung Cancer (NSCLC) Management
description	Lung cancer is the leading cause of cancer-related deaths worldwide. Despite growing efforts for its early detection by screening populations at risk, the majority of lung cancer patients are still diagnosed in an advanced stage. The management of lung cancer has dramatically improved in the last decade and is no longer based on the “one-fits-all” paradigm or the general histological classification of non-small cell versus small cell lung cancer. Emerging options of targeted therapies and immunotherapies have shifted the management of lung cancer to a more personalized treatment approach, significantly influencing the clinical course and outcome of the disease. Molecular biomarkers have emerged as valuable tools in the prognosis and prediction of therapy response. In this review, we discuss the relevant biomarkers used in the clinical management of lung tumors, from diagnosis to prognosis. We also discuss promising new biomarkers, focusing on non-small cell lung cancer as the most abundant type of lung cancer.
format	article
author	Maja Šutić Ana Vukić Jurica Baranašić Asta Försti Feđa Džubur Miroslav Samaržija Marko Jakopović Luka Brčić Jelena Knežević
author_facet	Maja Šutić Ana Vukić Jurica Baranašić Asta Försti Feđa Džubur Miroslav Samaržija Marko Jakopović Luka Brčić Jelena Knežević
author_sort	Maja Šutić
title	Diagnostic, Predictive, and Prognostic Biomarkers in Non-Small Cell Lung Cancer (NSCLC) Management
title_short	Diagnostic, Predictive, and Prognostic Biomarkers in Non-Small Cell Lung Cancer (NSCLC) Management
title_full	Diagnostic, Predictive, and Prognostic Biomarkers in Non-Small Cell Lung Cancer (NSCLC) Management
title_fullStr	Diagnostic, Predictive, and Prognostic Biomarkers in Non-Small Cell Lung Cancer (NSCLC) Management
title_full_unstemmed	Diagnostic, Predictive, and Prognostic Biomarkers in Non-Small Cell Lung Cancer (NSCLC) Management
title_sort	diagnostic, predictive, and prognostic biomarkers in non-small cell lung cancer (nsclc) management
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/00f9bdc3beec41cc9b5219b955f161b9
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Diagnostic, Predictive, and Prognostic Biomarkers in Non-Small Cell Lung Cancer (NSCLC) Management

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