Construction of poly-N-heterocyclic scaffolds via the controlled reactivity of Cu-allenylidene intermediates

Copper-catalysed annulation of allenylidenes provides an opportunity to target the alpha, beta, or gamma positions of the allenylidene, but achieving this control is challenging. Here substrate control allows selectivity between these three positions in the enantioselective cyclisation of ethynyl be...

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Autores principales:	Malla Reddy Gannarapu, Takanori Imai, Kentaro Iwaki, Seiji Tsuzuki, Norio Shibata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/00fcb24ec6394783853319da33a9ebed
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spelling	oai:doaj.org-article:00fcb24ec6394783853319da33a9ebed2021-11-21T12:03:53ZConstruction of poly-N-heterocyclic scaffolds via the controlled reactivity of Cu-allenylidene intermediates10.1038/s42004-021-00596-x2399-3669https://doaj.org/article/00fcb24ec6394783853319da33a9ebed2021-11-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00596-xhttps://doaj.org/toc/2399-3669Copper-catalysed annulation of allenylidenes provides an opportunity to target the alpha, beta, or gamma positions of the allenylidene, but achieving this control is challenging. Here substrate control allows selectivity between these three positions in the enantioselective cyclisation of ethynyl benzoxazinanones and sulfamate-derived cyclic imines.Malla Reddy GannarapuTakanori ImaiKentaro IwakiSeiji TsuzukiNorio ShibataNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Malla Reddy Gannarapu Takanori Imai Kentaro Iwaki Seiji Tsuzuki Norio Shibata Construction of poly-N-heterocyclic scaffolds via the controlled reactivity of Cu-allenylidene intermediates
description	Copper-catalysed annulation of allenylidenes provides an opportunity to target the alpha, beta, or gamma positions of the allenylidene, but achieving this control is challenging. Here substrate control allows selectivity between these three positions in the enantioselective cyclisation of ethynyl benzoxazinanones and sulfamate-derived cyclic imines.
format	article
author	Malla Reddy Gannarapu Takanori Imai Kentaro Iwaki Seiji Tsuzuki Norio Shibata
author_facet	Malla Reddy Gannarapu Takanori Imai Kentaro Iwaki Seiji Tsuzuki Norio Shibata
author_sort	Malla Reddy Gannarapu
title	Construction of poly-N-heterocyclic scaffolds via the controlled reactivity of Cu-allenylidene intermediates
title_short	Construction of poly-N-heterocyclic scaffolds via the controlled reactivity of Cu-allenylidene intermediates
title_full	Construction of poly-N-heterocyclic scaffolds via the controlled reactivity of Cu-allenylidene intermediates
title_fullStr	Construction of poly-N-heterocyclic scaffolds via the controlled reactivity of Cu-allenylidene intermediates
title_full_unstemmed	Construction of poly-N-heterocyclic scaffolds via the controlled reactivity of Cu-allenylidene intermediates
title_sort	construction of poly-n-heterocyclic scaffolds via the controlled reactivity of cu-allenylidene intermediates
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/00fcb24ec6394783853319da33a9ebed
work_keys_str_mv	AT mallareddygannarapu constructionofpolynheterocyclicscaffoldsviathecontrolledreactivityofcuallenylideneintermediates AT takanoriimai constructionofpolynheterocyclicscaffoldsviathecontrolledreactivityofcuallenylideneintermediates AT kentaroiwaki constructionofpolynheterocyclicscaffoldsviathecontrolledreactivityofcuallenylideneintermediates AT seijitsuzuki constructionofpolynheterocyclicscaffoldsviathecontrolledreactivityofcuallenylideneintermediates AT norioshibata constructionofpolynheterocyclicscaffoldsviathecontrolledreactivityofcuallenylideneintermediates
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Construction of poly-N-heterocyclic scaffolds via the controlled reactivity of Cu-allenylidene intermediates

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