Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin

The enzyme LspA from the human pathogen Staphylococcus aureus (MRSA) contributes to the integrity and function of the bacterial cell envelope. Here, authors provide crystal structures of LspA in complex with two natural antibiotics, which have profoundly different structures but inhibit LspA in an i...

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Autores principales:	Samir Olatunji, Xiaoxiao Yu, Jonathan Bailey, Chia-Ying Huang, Marta Zapotoczna, Katherine Bowen, Maja Remškar, Rolf Müller, Eoin M. Scanlan, Joan A. Geoghegan, Vincent Olieric, Martin Caffrey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/01038f4ee14b4c098398c5a500858933
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spelling	oai:doaj.org-article:01038f4ee14b4c098398c5a5008589332021-12-02T14:41:15ZStructures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin10.1038/s41467-019-13724-y2041-1723https://doaj.org/article/01038f4ee14b4c098398c5a5008589332020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13724-yhttps://doaj.org/toc/2041-1723The enzyme LspA from the human pathogen Staphylococcus aureus (MRSA) contributes to the integrity and function of the bacterial cell envelope. Here, authors provide crystal structures of LspA in complex with two natural antibiotics, which have profoundly different structures but inhibit LspA in an identical way.Samir OlatunjiXiaoxiao YuJonathan BaileyChia-Ying HuangMarta ZapotocznaKatherine BowenMaja RemškarRolf MüllerEoin M. ScanlanJoan A. GeogheganVincent OliericMartin CaffreyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Samir Olatunji Xiaoxiao Yu Jonathan Bailey Chia-Ying Huang Marta Zapotoczna Katherine Bowen Maja Remškar Rolf Müller Eoin M. Scanlan Joan A. Geoghegan Vincent Olieric Martin Caffrey Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin
description	The enzyme LspA from the human pathogen Staphylococcus aureus (MRSA) contributes to the integrity and function of the bacterial cell envelope. Here, authors provide crystal structures of LspA in complex with two natural antibiotics, which have profoundly different structures but inhibit LspA in an identical way.
format	article
author	Samir Olatunji Xiaoxiao Yu Jonathan Bailey Chia-Ying Huang Marta Zapotoczna Katherine Bowen Maja Remškar Rolf Müller Eoin M. Scanlan Joan A. Geoghegan Vincent Olieric Martin Caffrey
author_facet	Samir Olatunji Xiaoxiao Yu Jonathan Bailey Chia-Ying Huang Marta Zapotoczna Katherine Bowen Maja Remškar Rolf Müller Eoin M. Scanlan Joan A. Geoghegan Vincent Olieric Martin Caffrey
author_sort	Samir Olatunji
title	Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin
title_short	Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin
title_full	Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin
title_fullStr	Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin
title_full_unstemmed	Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin
title_sort	structures of lipoprotein signal peptidase ii from staphylococcus aureus complexed with antibiotics globomycin and myxovirescin
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/01038f4ee14b4c098398c5a500858933
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Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin

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