Surface-Modified Nanocellulose for Application in Biomedical Engineering and Nanomedicine: A Review

Silvia Tortorella, Veronica Vetri Buratti, Mirko Maturi, Letizia Sambri, Mauro Comes Franchini, Erica Locatelli Department of Industrial Chemistry “Toso Montanari”, Alma Mater Studiorum – University of Bologna, Bologna 40136, ItalyCorrespondence: Erica Locatelli Email e...

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Autores principales:	Tortorella S, Vetri Buratti V, Maturi M, Sambri L, Comes Franchini M, Locatelli E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	nanocelluse surface modification drug delivery scaffold tissue engineering Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0105b3beeb974ecc99b4238fb09b1392
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spelling	oai:doaj.org-article:0105b3beeb974ecc99b4238fb09b13922021-12-02T15:12:06ZSurface-Modified Nanocellulose for Application in Biomedical Engineering and Nanomedicine: A Review1178-2013https://doaj.org/article/0105b3beeb974ecc99b4238fb09b13922020-12-01T00:00:00Zhttps://www.dovepress.com/surface-modified-nanocellulose-for-application-in-biomedical-engineeri-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Silvia Tortorella, Veronica Vetri Buratti, Mirko Maturi, Letizia Sambri, Mauro Comes Franchini, Erica Locatelli Department of Industrial Chemistry “Toso Montanari”, Alma Mater Studiorum – University of Bologna, Bologna 40136, ItalyCorrespondence: Erica Locatelli Email erica.locatelli2@unibo.itAbstract: Presently, a plenty of concerns related to the environment are due to the overuse of petroleum-based chemicals and products; the synthesis of functional materials, starting from the natural sources, is the current trend in research. The interest for nanocellulose has recently increased in a huge range of fields, from the material science to the biomedical engineering. Nanocellulose gained this leading role because of several reasons: its natural abundance on this planet, the excellent mechanical and optical features, the good biocompatibility and the attractive capability of undergoing surface chemical modifications. Nanocellulose surface tuning techniques are adopted by the high reactivity of the hydroxyl groups available; the chemical modifications are mainly performed to introduce either charged or hydrophobic moieties that include amination, esterification, oxidation, silylation, carboxymethylation, epoxidation, sulfonation, thiol- and azido-functional capability. Despite the several already published papers regarding nanocellulose, the aim of this review involves discussing the surface chemical functional capability of nanocellulose and the subsequent applications in the main areas of nanocellulose research, such as drug delivery, biosensing/bioimaging, tissue regeneration and bioprinting, according to these modifications. The final goal of this review is to provide a novel and unusual overview on this topic that is continuously under expansion for its intrinsic sophisticated properties.Keywords: nanocelluse, surface modification, drug delivery, scaffold, tissue engineeringTortorella SVetri Buratti VMaturi MSambri LComes Franchini MLocatelli EDove Medical Pressarticlenanocellusesurface modificationdrug deliveryscaffoldtissue engineeringMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 9909-9937 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanocelluse surface modification drug delivery scaffold tissue engineering Medicine (General) R5-920
spellingShingle	nanocelluse surface modification drug delivery scaffold tissue engineering Medicine (General) R5-920 Tortorella S Vetri Buratti V Maturi M Sambri L Comes Franchini M Locatelli E Surface-Modified Nanocellulose for Application in Biomedical Engineering and Nanomedicine: A Review
description	Silvia Tortorella, Veronica Vetri Buratti, Mirko Maturi, Letizia Sambri, Mauro Comes Franchini, Erica Locatelli Department of Industrial Chemistry “Toso Montanari”, Alma Mater Studiorum – University of Bologna, Bologna 40136, ItalyCorrespondence: Erica Locatelli Email erica.locatelli2@unibo.itAbstract: Presently, a plenty of concerns related to the environment are due to the overuse of petroleum-based chemicals and products; the synthesis of functional materials, starting from the natural sources, is the current trend in research. The interest for nanocellulose has recently increased in a huge range of fields, from the material science to the biomedical engineering. Nanocellulose gained this leading role because of several reasons: its natural abundance on this planet, the excellent mechanical and optical features, the good biocompatibility and the attractive capability of undergoing surface chemical modifications. Nanocellulose surface tuning techniques are adopted by the high reactivity of the hydroxyl groups available; the chemical modifications are mainly performed to introduce either charged or hydrophobic moieties that include amination, esterification, oxidation, silylation, carboxymethylation, epoxidation, sulfonation, thiol- and azido-functional capability. Despite the several already published papers regarding nanocellulose, the aim of this review involves discussing the surface chemical functional capability of nanocellulose and the subsequent applications in the main areas of nanocellulose research, such as drug delivery, biosensing/bioimaging, tissue regeneration and bioprinting, according to these modifications. The final goal of this review is to provide a novel and unusual overview on this topic that is continuously under expansion for its intrinsic sophisticated properties.Keywords: nanocelluse, surface modification, drug delivery, scaffold, tissue engineering
format	article
author	Tortorella S Vetri Buratti V Maturi M Sambri L Comes Franchini M Locatelli E
author_facet	Tortorella S Vetri Buratti V Maturi M Sambri L Comes Franchini M Locatelli E
author_sort	Tortorella S
title	Surface-Modified Nanocellulose for Application in Biomedical Engineering and Nanomedicine: A Review
title_short	Surface-Modified Nanocellulose for Application in Biomedical Engineering and Nanomedicine: A Review
title_full	Surface-Modified Nanocellulose for Application in Biomedical Engineering and Nanomedicine: A Review
title_fullStr	Surface-Modified Nanocellulose for Application in Biomedical Engineering and Nanomedicine: A Review
title_full_unstemmed	Surface-Modified Nanocellulose for Application in Biomedical Engineering and Nanomedicine: A Review
title_sort	surface-modified nanocellulose for application in biomedical engineering and nanomedicine: a review
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/0105b3beeb974ecc99b4238fb09b1392
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Surface-Modified Nanocellulose for Application in Biomedical Engineering and Nanomedicine: A Review

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