Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α

Juliana O Toledo,1 Clayton F Moraes,2,3 Vinícius C Souza,2 Audrey C Tonet-Furioso,2 Luís CC Afonso,4 Cláudio Córdova,3 Otávio T Nóbrega1,2 1Graduate Program in Health Sciences, 2Graduate Program in Medical Sciences, University of Bra...

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Autores principales:	Toledo JO, Moraes CF, Souza VC, Tonet-Furioso AC, Afonso LCC, Córdova C, Nóbrega OT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	renin-angiotensin system cytokine hypertension drug therapy guidelines polymorphism. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/0107c04001df4372ba22560b172e907d
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spelling	oai:doaj.org-article:0107c04001df4372ba22560b172e907d2021-12-02T01:40:08ZTailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α1178-1998https://doaj.org/article/0107c04001df4372ba22560b172e907d2015-01-01T00:00:00Zhttps://www.dovepress.com/tailored-antihypertensive-drug-therapy-prescribed-to-older-women-atten-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Juliana O Toledo,1 Clayton F Moraes,2,3 Vinícius C Souza,2 Audrey C Tonet-Furioso,2 Luís CC Afonso,4 Cláudio Córdova,3 Otávio T Nóbrega1,2 1Graduate Program in Health Sciences, 2Graduate Program in Medical Sciences, University of Brasília, Brasília, 3Graduate Program in Gerontology, Catholic University of Brasília, Brasília, 4Research Center in Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Brazil Objective: To test the hypothesis that antihypertensive drug therapy produces anti-inflammatory effects in clinical practice, this study investigated circulating levels of selected proinflammatory mediators (interleukin-6 [IL-6], tumor necrosis factor-alpha [TNF-α], and interferon-γ [INF-γ]) in response to multivariate drug directions for blood pressure (BP) control.Methods: Prospective study involving 110 hypertensive, community-dwelling older women with different metabolic disorders. A short-term BP-lowering drug therapy was conducted according to current Brazilian guidelines on hypertension, and basal cytokine levels were measured before and after intervention.Results: Interventions were found to represent current hypertension-management practices in Brazil and corresponded to a significant reduction in systolic and diastolic BP levels in a whole-group analysis, as well as when users and nonusers of the most common therapeutic classes were considered separately. Considering all patients, mean IL-6 and TNF-α levels showed a significant decrease in circulating concentrations (P<0.01) at the endpoint compared with baseline, whereas the mean INF-γ level was not significantly different from baseline values. In separate analyses, only users of antagonists of the renin–angiotensin system and users of diuretics exhibited the same significant treatment-induced reduction in serum IL-6 and TNF-α observed in the whole group.Conclusion: Our data demonstrates that a clinically guided antihypertensive treatment is effective in reversing the low-grade proinflammatory state of serum cytokines found in postmenopausal women and support extracardiac benefits from diuretics and renin–angiotensin system antagonists. Keywords: renin–angiotensin system, cytokine, hypertension, drug therapy, guidelines, inflammation Toledo JOMoraes CFSouza VCTonet-Furioso ACAfonso LCCCórdova CNóbrega OTDove Medical Pressarticlerenin-angiotensin systemcytokinehypertensiondrug therapyguidelinespolymorphism.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 10, Pp 209-215 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	renin-angiotensin system cytokine hypertension drug therapy guidelines polymorphism. Geriatrics RC952-954.6
spellingShingle	renin-angiotensin system cytokine hypertension drug therapy guidelines polymorphism. Geriatrics RC952-954.6 Toledo JO Moraes CF Souza VC Tonet-Furioso AC Afonso LCC Córdova C Nóbrega OT Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α
description	Juliana O Toledo,1 Clayton F Moraes,2,3 Vinícius C Souza,2 Audrey C Tonet-Furioso,2 Luís CC Afonso,4 Cláudio Córdova,3 Otávio T Nóbrega1,2 1Graduate Program in Health Sciences, 2Graduate Program in Medical Sciences, University of Brasília, Brasília, 3Graduate Program in Gerontology, Catholic University of Brasília, Brasília, 4Research Center in Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Brazil Objective: To test the hypothesis that antihypertensive drug therapy produces anti-inflammatory effects in clinical practice, this study investigated circulating levels of selected proinflammatory mediators (interleukin-6 [IL-6], tumor necrosis factor-alpha [TNF-α], and interferon-γ [INF-γ]) in response to multivariate drug directions for blood pressure (BP) control.Methods: Prospective study involving 110 hypertensive, community-dwelling older women with different metabolic disorders. A short-term BP-lowering drug therapy was conducted according to current Brazilian guidelines on hypertension, and basal cytokine levels were measured before and after intervention.Results: Interventions were found to represent current hypertension-management practices in Brazil and corresponded to a significant reduction in systolic and diastolic BP levels in a whole-group analysis, as well as when users and nonusers of the most common therapeutic classes were considered separately. Considering all patients, mean IL-6 and TNF-α levels showed a significant decrease in circulating concentrations (P<0.01) at the endpoint compared with baseline, whereas the mean INF-γ level was not significantly different from baseline values. In separate analyses, only users of antagonists of the renin–angiotensin system and users of diuretics exhibited the same significant treatment-induced reduction in serum IL-6 and TNF-α observed in the whole group.Conclusion: Our data demonstrates that a clinically guided antihypertensive treatment is effective in reversing the low-grade proinflammatory state of serum cytokines found in postmenopausal women and support extracardiac benefits from diuretics and renin–angiotensin system antagonists. Keywords: renin–angiotensin system, cytokine, hypertension, drug therapy, guidelines, inflammation
format	article
author	Toledo JO Moraes CF Souza VC Tonet-Furioso AC Afonso LCC Córdova C Nóbrega OT
author_facet	Toledo JO Moraes CF Souza VC Tonet-Furioso AC Afonso LCC Córdova C Nóbrega OT
author_sort	Toledo JO
title	Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α
title_short	Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α
title_full	Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α
title_fullStr	Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α
title_full_unstemmed	Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α
title_sort	tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/0107c04001df4372ba22560b172e907d
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Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-&alpha;

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Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α