Cognitive processing speed in older adults: relationship with white matter integrity.

Cognitive processing slows with age. We sought to determine the importance of white matter integrity, assessed by diffusion tensor imaging (DTI), at influencing cognitive processing speed among normal older adults, assessed using a novel battery of computerized, non-verbal, choice reaction time task...

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Autores principales:	Geoffrey A Kerchner, Caroline A Racine, Sandra Hale, Reva Wilheim, Victor Laluz, Bruce L Miller, Joel H Kramer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/01081524e6a349e29665a5087c2dc5ad
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id	oai:doaj.org-article:01081524e6a349e29665a5087c2dc5ad
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spelling	oai:doaj.org-article:01081524e6a349e29665a5087c2dc5ad2021-11-18T08:07:42ZCognitive processing speed in older adults: relationship with white matter integrity.1932-620310.1371/journal.pone.0050425https://doaj.org/article/01081524e6a349e29665a5087c2dc5ad2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23185621/?tool=EBIhttps://doaj.org/toc/1932-6203Cognitive processing slows with age. We sought to determine the importance of white matter integrity, assessed by diffusion tensor imaging (DTI), at influencing cognitive processing speed among normal older adults, assessed using a novel battery of computerized, non-verbal, choice reaction time tasks. We studied 131 cognitively normal adults aged 55-87 using a cross-sectional design. Each participant underwent our test battery, as well as MRI with DTI. We carried out cross-subject comparisons using tract-based spatial statistics. As expected, reaction time slowed significantly with age. In diffuse areas of frontal and parietal white matter, especially the anterior corpus callosum, fractional anisotropy values correlated negatively with reaction time. The genu and body of the corpus callosum, superior longitudinal fasciculus, and inferior fronto-occipital fasciculus were among the areas most involved. This relationship was not explained by gray or white matter atrophy or by white matter lesion volume. In a statistical mediation analysis, loss of white matter integrity mediated the relationship between age and cognitive processing speed.Geoffrey A KerchnerCaroline A RacineSandra HaleReva WilheimVictor LaluzBruce L MillerJoel H KramerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e50425 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Geoffrey A Kerchner Caroline A Racine Sandra Hale Reva Wilheim Victor Laluz Bruce L Miller Joel H Kramer Cognitive processing speed in older adults: relationship with white matter integrity.
description	Cognitive processing slows with age. We sought to determine the importance of white matter integrity, assessed by diffusion tensor imaging (DTI), at influencing cognitive processing speed among normal older adults, assessed using a novel battery of computerized, non-verbal, choice reaction time tasks. We studied 131 cognitively normal adults aged 55-87 using a cross-sectional design. Each participant underwent our test battery, as well as MRI with DTI. We carried out cross-subject comparisons using tract-based spatial statistics. As expected, reaction time slowed significantly with age. In diffuse areas of frontal and parietal white matter, especially the anterior corpus callosum, fractional anisotropy values correlated negatively with reaction time. The genu and body of the corpus callosum, superior longitudinal fasciculus, and inferior fronto-occipital fasciculus were among the areas most involved. This relationship was not explained by gray or white matter atrophy or by white matter lesion volume. In a statistical mediation analysis, loss of white matter integrity mediated the relationship between age and cognitive processing speed.
format	article
author	Geoffrey A Kerchner Caroline A Racine Sandra Hale Reva Wilheim Victor Laluz Bruce L Miller Joel H Kramer
author_facet	Geoffrey A Kerchner Caroline A Racine Sandra Hale Reva Wilheim Victor Laluz Bruce L Miller Joel H Kramer
author_sort	Geoffrey A Kerchner
title	Cognitive processing speed in older adults: relationship with white matter integrity.
title_short	Cognitive processing speed in older adults: relationship with white matter integrity.
title_full	Cognitive processing speed in older adults: relationship with white matter integrity.
title_fullStr	Cognitive processing speed in older adults: relationship with white matter integrity.
title_full_unstemmed	Cognitive processing speed in older adults: relationship with white matter integrity.
title_sort	cognitive processing speed in older adults: relationship with white matter integrity.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/01081524e6a349e29665a5087c2dc5ad
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Cognitive processing speed in older adults: relationship with white matter integrity.

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