Current Advances in the Use of Nanophytomedicine Therapies for Human Cardiovascular Diseases

Mahvash Hesari,1 Pantea Mohammadi,1 Fatemeh Khademi,1 Dareuosh Shackebaei,1 Saeideh Momtaz,2– 5 Narges Moasefi,1 Mohammad Hosein Farzaei,6 Mohammad Abdollahi3,4 1Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Medi...

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Autores principales:	Hesari M, Mohammadi P, Khademi F, Shackebaei D, Momtaz S, Moasefi N, Farzaei MH, Abdollahi M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	cardiovascular diseases medicinal plants natural products nanoformulation nanoparticles Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/01091452f821465f91dc2bfbe98ccf25
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spelling	oai:doaj.org-article:01091452f821465f91dc2bfbe98ccf252021-12-02T17:21:51ZCurrent Advances in the Use of Nanophytomedicine Therapies for Human Cardiovascular Diseases1178-2013https://doaj.org/article/01091452f821465f91dc2bfbe98ccf252021-05-01T00:00:00Zhttps://www.dovepress.com/current-advances-in-the-use-of-nanophytomedicine-therapies-for-human-c-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Mahvash Hesari,1 Pantea Mohammadi,1 Fatemeh Khademi,1 Dareuosh Shackebaei,1 Saeideh Momtaz,2– 5 Narges Moasefi,1 Mohammad Hosein Farzaei,6 Mohammad Abdollahi3,4 1Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Tehran, Iran; 3Toxicology and Diseases Group, Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; 4Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 5Gastrointestinal Pharmacology Interest Group, Universal Scientific Education and Research Network (USERN), Tehran, Iran; 6Medical Technology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, IranCorrespondence: Mohammad Hosein FarzaeiMedical Technology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, IranEmail mh.farzaei@gmail.comMohammad AbdollahiDepartment of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, IranEmail Mohammad@TUMS.Ac.IrAbstract: Considering the high prevalence of cardiovascular diseases (CVDs), the primary cause of death during the last several decades, it is necessary to develop proper strategies for the prevention and treatment of CVDs. Given the excessive side effects of current therapies, alternative therapeutic approaches like medicinal plants and natural products are preferred. Lower toxicity, chemical diversity, cost-effectiveness, and proven therapeutic potentials make natural products superior compared to other products. Nanoformulation methods improve the solubility, bioavailability, circulation time, surface area-to-volume ratio, systemic adverse side effects, and drug delivery efficiency of these medications. This study intended to review the functionality of the most recent nanoformulated medicinal plants and/or natural products against various cardiovascular conditions such as hypertension, atherosclerosis, thrombosis, and myocardial infarction. Literature review revealed that curcumin, quercetin, and resveratrol were the most applied natural products, respectively. Combination therapy, conjugation, or fabrication of nanoparticles and nanocarriers improved the applications and therapeutic efficacy of herbal- or natural-based nanoformulations. In the context of CVDs prevention and/or treatment, available data suggest that natural-based nanoformulations are considerably efficient, alone or in blend with other herbal/synthetic medicines. However, clinical trials are mandatory to elucidate the safety, cardioprotective effect, and mechanism of actions of nanophytomedicines.Keywords: cardiovascular diseases, medicinal plants, natural products, nanoformulation, nanoparticlesHesari MMohammadi PKhademi FShackebaei DMomtaz SMoasefi NFarzaei MHAbdollahi MDove Medical Pressarticlecardiovascular diseasesmedicinal plantsnatural productsnanoformulationnanoparticlesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 3293-3315 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular diseases medicinal plants natural products nanoformulation nanoparticles Medicine (General) R5-920
spellingShingle	cardiovascular diseases medicinal plants natural products nanoformulation nanoparticles Medicine (General) R5-920 Hesari M Mohammadi P Khademi F Shackebaei D Momtaz S Moasefi N Farzaei MH Abdollahi M Current Advances in the Use of Nanophytomedicine Therapies for Human Cardiovascular Diseases
description	Mahvash Hesari,1 Pantea Mohammadi,1 Fatemeh Khademi,1 Dareuosh Shackebaei,1 Saeideh Momtaz,2– 5 Narges Moasefi,1 Mohammad Hosein Farzaei,6 Mohammad Abdollahi3,4 1Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Tehran, Iran; 3Toxicology and Diseases Group, Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; 4Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 5Gastrointestinal Pharmacology Interest Group, Universal Scientific Education and Research Network (USERN), Tehran, Iran; 6Medical Technology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, IranCorrespondence: Mohammad Hosein FarzaeiMedical Technology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, IranEmail mh.farzaei@gmail.comMohammad AbdollahiDepartment of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, IranEmail Mohammad@TUMS.Ac.IrAbstract: Considering the high prevalence of cardiovascular diseases (CVDs), the primary cause of death during the last several decades, it is necessary to develop proper strategies for the prevention and treatment of CVDs. Given the excessive side effects of current therapies, alternative therapeutic approaches like medicinal plants and natural products are preferred. Lower toxicity, chemical diversity, cost-effectiveness, and proven therapeutic potentials make natural products superior compared to other products. Nanoformulation methods improve the solubility, bioavailability, circulation time, surface area-to-volume ratio, systemic adverse side effects, and drug delivery efficiency of these medications. This study intended to review the functionality of the most recent nanoformulated medicinal plants and/or natural products against various cardiovascular conditions such as hypertension, atherosclerosis, thrombosis, and myocardial infarction. Literature review revealed that curcumin, quercetin, and resveratrol were the most applied natural products, respectively. Combination therapy, conjugation, or fabrication of nanoparticles and nanocarriers improved the applications and therapeutic efficacy of herbal- or natural-based nanoformulations. In the context of CVDs prevention and/or treatment, available data suggest that natural-based nanoformulations are considerably efficient, alone or in blend with other herbal/synthetic medicines. However, clinical trials are mandatory to elucidate the safety, cardioprotective effect, and mechanism of actions of nanophytomedicines.Keywords: cardiovascular diseases, medicinal plants, natural products, nanoformulation, nanoparticles
format	article
author	Hesari M Mohammadi P Khademi F Shackebaei D Momtaz S Moasefi N Farzaei MH Abdollahi M
author_facet	Hesari M Mohammadi P Khademi F Shackebaei D Momtaz S Moasefi N Farzaei MH Abdollahi M
author_sort	Hesari M
title	Current Advances in the Use of Nanophytomedicine Therapies for Human Cardiovascular Diseases
title_short	Current Advances in the Use of Nanophytomedicine Therapies for Human Cardiovascular Diseases
title_full	Current Advances in the Use of Nanophytomedicine Therapies for Human Cardiovascular Diseases
title_fullStr	Current Advances in the Use of Nanophytomedicine Therapies for Human Cardiovascular Diseases
title_full_unstemmed	Current Advances in the Use of Nanophytomedicine Therapies for Human Cardiovascular Diseases
title_sort	current advances in the use of nanophytomedicine therapies for human cardiovascular diseases
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/01091452f821465f91dc2bfbe98ccf25
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Current Advances in the Use of Nanophytomedicine Therapies for Human Cardiovascular Diseases

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