Effects of long sleep time and irregular sleep–wake rhythm on cognitive function in older people

Abstract Sleep disturbances and cognitive decline are common in older adults. We aimed to investigate the effects of the total sleep time (TST) and sleep–wake rhythm on executive function and working memory in older adults. In 63 older participants, we measured the TST, wake after sleep onset (WASO)...

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Autores principales:	Masato Okuda, Akiko Noda, Kunihiro Iwamoto, Honoka Nakashima, Kozue Takeda, Seiko Miyata, Fumihiko Yasuma, Norio Ozaki, Akito Shimouchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/010c723ce88c4bfaaa4e638e8474fe5f
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spelling	oai:doaj.org-article:010c723ce88c4bfaaa4e638e8474fe5f2021-12-02T14:25:16ZEffects of long sleep time and irregular sleep–wake rhythm on cognitive function in older people10.1038/s41598-021-85817-y2045-2322https://doaj.org/article/010c723ce88c4bfaaa4e638e8474fe5f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85817-yhttps://doaj.org/toc/2045-2322Abstract Sleep disturbances and cognitive decline are common in older adults. We aimed to investigate the effects of the total sleep time (TST) and sleep–wake rhythm on executive function and working memory in older adults. In 63 older participants, we measured the TST, wake after sleep onset (WASO), and sleep timing (midpoint between bedtime and wake-up time) using actigraphy. Executive function was evaluated with the trail making test B (TMT-B) and Wisconsin card sorting test (WCST). The number of back task (N-back task) was used to measure working memory. Participants with a TST ≥ 8 h had a significantly lower percentage of correct answers (% correct) on the 1-back task than those with a TST < 8 h. The % correct on the 1-back task was significantly correlated with the TST, WASO, and sleep timing. Multiple regression analyses revealed that the TST and sleep timing were significant factors of the % correct on the 1-back task. The TMT-B score was significantly correlated with the sleep timing. Category achievement on the WCST was significantly correlated with the standard deviation of the sleep timing. Therefore, a long sleep time and an irregular sleep–wake rhythm could have adverse effects on executive function and working memory in older people.Masato OkudaAkiko NodaKunihiro IwamotoHonoka NakashimaKozue TakedaSeiko MiyataFumihiko YasumaNorio OzakiAkito ShimouchiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masato Okuda Akiko Noda Kunihiro Iwamoto Honoka Nakashima Kozue Takeda Seiko Miyata Fumihiko Yasuma Norio Ozaki Akito Shimouchi Effects of long sleep time and irregular sleep–wake rhythm on cognitive function in older people
description	Abstract Sleep disturbances and cognitive decline are common in older adults. We aimed to investigate the effects of the total sleep time (TST) and sleep–wake rhythm on executive function and working memory in older adults. In 63 older participants, we measured the TST, wake after sleep onset (WASO), and sleep timing (midpoint between bedtime and wake-up time) using actigraphy. Executive function was evaluated with the trail making test B (TMT-B) and Wisconsin card sorting test (WCST). The number of back task (N-back task) was used to measure working memory. Participants with a TST ≥ 8 h had a significantly lower percentage of correct answers (% correct) on the 1-back task than those with a TST < 8 h. The % correct on the 1-back task was significantly correlated with the TST, WASO, and sleep timing. Multiple regression analyses revealed that the TST and sleep timing were significant factors of the % correct on the 1-back task. The TMT-B score was significantly correlated with the sleep timing. Category achievement on the WCST was significantly correlated with the standard deviation of the sleep timing. Therefore, a long sleep time and an irregular sleep–wake rhythm could have adverse effects on executive function and working memory in older people.
format	article
author	Masato Okuda Akiko Noda Kunihiro Iwamoto Honoka Nakashima Kozue Takeda Seiko Miyata Fumihiko Yasuma Norio Ozaki Akito Shimouchi
author_facet	Masato Okuda Akiko Noda Kunihiro Iwamoto Honoka Nakashima Kozue Takeda Seiko Miyata Fumihiko Yasuma Norio Ozaki Akito Shimouchi
author_sort	Masato Okuda
title	Effects of long sleep time and irregular sleep–wake rhythm on cognitive function in older people
title_short	Effects of long sleep time and irregular sleep–wake rhythm on cognitive function in older people
title_full	Effects of long sleep time and irregular sleep–wake rhythm on cognitive function in older people
title_fullStr	Effects of long sleep time and irregular sleep–wake rhythm on cognitive function in older people
title_full_unstemmed	Effects of long sleep time and irregular sleep–wake rhythm on cognitive function in older people
title_sort	effects of long sleep time and irregular sleep–wake rhythm on cognitive function in older people
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/010c723ce88c4bfaaa4e638e8474fe5f
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Effects of long sleep time and irregular sleep–wake rhythm on cognitive function in older people

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