Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus

Tracheal development arises due to tube morphogenesis but how this is regulated is unclear. Here, the authors identify polarization of smooth muscle progenitors as controlling murine tracheal development, activating noncanonical Wnt signaling followed by subepithelial morphogenesis and ring cartilag...

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Autores principales:	Keishi Kishimoto, Masaru Tamura, Michiru Nishita, Yasuhiro Minami, Akira Yamaoka, Takaya Abe, Mayo Shigeta, Mitsuru Morimoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/010cb63b7bb24d288070b261e2b6a9a1
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spelling	oai:doaj.org-article:010cb63b7bb24d288070b261e2b6a9a12021-12-02T14:39:46ZSynchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus10.1038/s41467-018-05189-22041-1723https://doaj.org/article/010cb63b7bb24d288070b261e2b6a9a12018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05189-2https://doaj.org/toc/2041-1723Tracheal development arises due to tube morphogenesis but how this is regulated is unclear. Here, the authors identify polarization of smooth muscle progenitors as controlling murine tracheal development, activating noncanonical Wnt signaling followed by subepithelial morphogenesis and ring cartilage development.Keishi KishimotoMasaru TamuraMichiru NishitaYasuhiro MinamiAkira YamaokaTakaya AbeMayo ShigetaMitsuru MorimotoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Keishi Kishimoto Masaru Tamura Michiru Nishita Yasuhiro Minami Akira Yamaoka Takaya Abe Mayo Shigeta Mitsuru Morimoto Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus
description	Tracheal development arises due to tube morphogenesis but how this is regulated is unclear. Here, the authors identify polarization of smooth muscle progenitors as controlling murine tracheal development, activating noncanonical Wnt signaling followed by subepithelial morphogenesis and ring cartilage development.
format	article
author	Keishi Kishimoto Masaru Tamura Michiru Nishita Yasuhiro Minami Akira Yamaoka Takaya Abe Mayo Shigeta Mitsuru Morimoto
author_facet	Keishi Kishimoto Masaru Tamura Michiru Nishita Yasuhiro Minami Akira Yamaoka Takaya Abe Mayo Shigeta Mitsuru Morimoto
author_sort	Keishi Kishimoto
title	Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus
title_short	Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus
title_full	Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus
title_fullStr	Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus
title_full_unstemmed	Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus
title_sort	synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/010cb63b7bb24d288070b261e2b6a9a1
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Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus

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