An Efficient Ionic Liquid-Mediated Extraction and Enrichment of Isoimperatorin from <i>Ostericum koreanum</i> (Max.) Kitagawa

Ionic liquids (ILs) have attracted significant interest because of their desirable properties. These characteristics have improved their application to overcome the shortcomings of conventional separation techniques for phytochemicals. In this study, several ILs were investigated for their capacity...

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Autores principales:	Alice Nguvoko Kiyonga, Gyu Hwan Park, Hyun Su Kim, Young-Ger Suh, Tae Kon Kim, Kiwon Jung
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ionic liquids isoimperatorin extraction crystallization enrichment <i>Ostericum koreanum</i> Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/010cd0dc09374ed2afce57aaabd928b5
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spelling	oai:doaj.org-article:010cd0dc09374ed2afce57aaabd928b52021-11-11T18:32:30ZAn Efficient Ionic Liquid-Mediated Extraction and Enrichment of Isoimperatorin from <i>Ostericum koreanum</i> (Max.) Kitagawa10.3390/molecules262165551420-3049https://doaj.org/article/010cd0dc09374ed2afce57aaabd928b52021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6555https://doaj.org/toc/1420-3049Ionic liquids (ILs) have attracted significant interest because of their desirable properties. These characteristics have improved their application to overcome the shortcomings of conventional separation techniques for phytochemicals. In this study, several ILs were investigated for their capacity to extract isoimperatorin, a bioactive furanocoumarin, from the roots of <i>Ostericum koreanum</i>. Herein, 1-Butyl-3-methylimidazolium tetrafluoroborate ([Bmim][BF<sub>4</sub>]) was selected as a promising IL for separating isoimperatorin. A central composite design was applied to optimize the extraction conditions. Under the optimal conditions, the yield of isoimperatorin reached 97.17 ± 1.84%. Additionally, the recovery of isoimperatorin from the [Bmim][BF<sub>4</sub>] solution was successfully achieved (87.73 ± 2.37%) by crystallization using water as an antisolvent. The purity of the isoimperatorin was greatly enhanced, from 0.26 ± 0.28% in the raw material to 26.94 ± 1.26% in the product, in a one-step crystallization process. Namely, an enhancement of approximately 103-folds was reached. The developed approach overcomes the shortcomings of conventional separation methods applied for gaining isoimperatorin by significantly reducing the laboriousness of the process and the consumption of volatile organic solvents. Moreover, the simplicity and effectiveness of the method are assumed to be valuable for producing isoimperatorin-enriched products and for promoting its purification. This work also confirms the efficiency of ILs as a promising material for the separation of phytochemicals.Alice Nguvoko KiyongaGyu Hwan ParkHyun Su KimYoung-Ger SuhTae Kon KimKiwon JungMDPI AGarticleionic liquidsisoimperatorinextractioncrystallizationenrichment<i>Ostericum koreanum</i>Organic chemistryQD241-441ENMolecules, Vol 26, Iss 6555, p 6555 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ionic liquids isoimperatorin extraction crystallization enrichment <i>Ostericum koreanum</i> Organic chemistry QD241-441
spellingShingle	ionic liquids isoimperatorin extraction crystallization enrichment <i>Ostericum koreanum</i> Organic chemistry QD241-441 Alice Nguvoko Kiyonga Gyu Hwan Park Hyun Su Kim Young-Ger Suh Tae Kon Kim Kiwon Jung An Efficient Ionic Liquid-Mediated Extraction and Enrichment of Isoimperatorin from <i>Ostericum koreanum</i> (Max.) Kitagawa
description	Ionic liquids (ILs) have attracted significant interest because of their desirable properties. These characteristics have improved their application to overcome the shortcomings of conventional separation techniques for phytochemicals. In this study, several ILs were investigated for their capacity to extract isoimperatorin, a bioactive furanocoumarin, from the roots of <i>Ostericum koreanum</i>. Herein, 1-Butyl-3-methylimidazolium tetrafluoroborate ([Bmim][BF<sub>4</sub>]) was selected as a promising IL for separating isoimperatorin. A central composite design was applied to optimize the extraction conditions. Under the optimal conditions, the yield of isoimperatorin reached 97.17 ± 1.84%. Additionally, the recovery of isoimperatorin from the [Bmim][BF<sub>4</sub>] solution was successfully achieved (87.73 ± 2.37%) by crystallization using water as an antisolvent. The purity of the isoimperatorin was greatly enhanced, from 0.26 ± 0.28% in the raw material to 26.94 ± 1.26% in the product, in a one-step crystallization process. Namely, an enhancement of approximately 103-folds was reached. The developed approach overcomes the shortcomings of conventional separation methods applied for gaining isoimperatorin by significantly reducing the laboriousness of the process and the consumption of volatile organic solvents. Moreover, the simplicity and effectiveness of the method are assumed to be valuable for producing isoimperatorin-enriched products and for promoting its purification. This work also confirms the efficiency of ILs as a promising material for the separation of phytochemicals.
format	article
author	Alice Nguvoko Kiyonga Gyu Hwan Park Hyun Su Kim Young-Ger Suh Tae Kon Kim Kiwon Jung
author_facet	Alice Nguvoko Kiyonga Gyu Hwan Park Hyun Su Kim Young-Ger Suh Tae Kon Kim Kiwon Jung
author_sort	Alice Nguvoko Kiyonga
title	An Efficient Ionic Liquid-Mediated Extraction and Enrichment of Isoimperatorin from <i>Ostericum koreanum</i> (Max.) Kitagawa
title_short	An Efficient Ionic Liquid-Mediated Extraction and Enrichment of Isoimperatorin from <i>Ostericum koreanum</i> (Max.) Kitagawa
title_full	An Efficient Ionic Liquid-Mediated Extraction and Enrichment of Isoimperatorin from <i>Ostericum koreanum</i> (Max.) Kitagawa
title_fullStr	An Efficient Ionic Liquid-Mediated Extraction and Enrichment of Isoimperatorin from <i>Ostericum koreanum</i> (Max.) Kitagawa
title_full_unstemmed	An Efficient Ionic Liquid-Mediated Extraction and Enrichment of Isoimperatorin from <i>Ostericum koreanum</i> (Max.) Kitagawa
title_sort	efficient ionic liquid-mediated extraction and enrichment of isoimperatorin from <i>ostericum koreanum</i> (max.) kitagawa
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/010cd0dc09374ed2afce57aaabd928b5
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An Efficient Ionic Liquid-Mediated Extraction and Enrichment of Isoimperatorin from <i>Ostericum koreanum</i> (Max.) Kitagawa

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