Oral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis

Martin Roesel1, Christoph Tappeiner2, Arnd Heiligenhaus1,3, Carsten Heinz1,31Department of Ophthalmology, St Franziskus-Hospital, Muenster, Germany; 2Department of Ophthalmology, Inselspital, University of Bern, Switzerland; 3University Duisburg-Essen, GermanyAbstract: Voclosporin, a novel immunomod...

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Autores principales:	Roesel M, Tappeiner C, Heiligenhaus A, Heinz C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/010ddd224a7e4211bc149b1b0c2d5022
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spelling	oai:doaj.org-article:010ddd224a7e4211bc149b1b0c2d50222021-12-02T05:53:53ZOral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis1177-54671177-5483https://doaj.org/article/010ddd224a7e4211bc149b1b0c2d50222011-09-01T00:00:00Zhttp://www.dovepress.com/oral-voclosporin-novel-calcineurin-inhibitor-for-treatment-of-noninfec-a8274https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Martin Roesel1, Christoph Tappeiner2, Arnd Heiligenhaus1,3, Carsten Heinz1,31Department of Ophthalmology, St Franziskus-Hospital, Muenster, Germany; 2Department of Ophthalmology, Inselspital, University of Bern, Switzerland; 3University Duisburg-Essen, GermanyAbstract: Voclosporin, a novel immunomodulatory drug inhibiting the calcineurin enzyme, was developed to prevent organ graft rejection and to treat autoimmune diseases. The chemical structure of voclosporin is similar to that of cyclosporine A, with a difference in one amino acid, leading to superior calcineurin inhibition and less variability in plasma concentration. Compared with placebo, voclosporin may significantly reduce inflammation and prevent recurrences of inflammation in patients with noninfectious uveitis. Future studies have to show if these advantages are accompanied by greater clinical efficacy and fewer side effects compared with the classic calcineurin inhibitors.Keywords: uveitis, immunosuppression, voclosporinRoesel MTappeiner CHeiligenhaus AHeinz CDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 1309-1313 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Roesel M Tappeiner C Heiligenhaus A Heinz C Oral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis
description	Martin Roesel1, Christoph Tappeiner2, Arnd Heiligenhaus1,3, Carsten Heinz1,31Department of Ophthalmology, St Franziskus-Hospital, Muenster, Germany; 2Department of Ophthalmology, Inselspital, University of Bern, Switzerland; 3University Duisburg-Essen, GermanyAbstract: Voclosporin, a novel immunomodulatory drug inhibiting the calcineurin enzyme, was developed to prevent organ graft rejection and to treat autoimmune diseases. The chemical structure of voclosporin is similar to that of cyclosporine A, with a difference in one amino acid, leading to superior calcineurin inhibition and less variability in plasma concentration. Compared with placebo, voclosporin may significantly reduce inflammation and prevent recurrences of inflammation in patients with noninfectious uveitis. Future studies have to show if these advantages are accompanied by greater clinical efficacy and fewer side effects compared with the classic calcineurin inhibitors.Keywords: uveitis, immunosuppression, voclosporin
format	article
author	Roesel M Tappeiner C Heiligenhaus A Heinz C
author_facet	Roesel M Tappeiner C Heiligenhaus A Heinz C
author_sort	Roesel M
title	Oral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis
title_short	Oral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis
title_full	Oral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis
title_fullStr	Oral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis
title_full_unstemmed	Oral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis
title_sort	oral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/010ddd224a7e4211bc149b1b0c2d5022
work_keys_str_mv	AT roeselm oralvoclosporinnovelcalcineurininhibitorfortreatmentofnoninfectiousuveitis AT tappeinerc oralvoclosporinnovelcalcineurininhibitorfortreatmentofnoninfectiousuveitis AT heiligenhausa oralvoclosporinnovelcalcineurininhibitorfortreatmentofnoninfectiousuveitis AT heinzc oralvoclosporinnovelcalcineurininhibitorfortreatmentofnoninfectiousuveitis
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Oral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis

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