The administration of 100% oxygen and respiratory drive in very preterm infants at birth.

<h4>Aim</h4>To retrospectively investigate the changes of SpO2 and respiratory drive in preterm infants at birth after administration of 100% oxygen.<h4>Methods</h4>Respiratory parameters, FiO2 and oximetry of infants <32 weeks gestation before and after receiving FiO2 1.0...

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Autores principales:	Jeroen J van Vonderen, Nadia E Narayen, Frans J Walther, Melissa L Siew, Peter G Davis, Stuart B Hooper, Arjan B te Pas
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/010dec31dad64e3eb68b70e10aed9afd
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spelling	oai:doaj.org-article:010dec31dad64e3eb68b70e10aed9afd2021-11-18T08:50:24ZThe administration of 100% oxygen and respiratory drive in very preterm infants at birth.1932-620310.1371/journal.pone.0076898https://doaj.org/article/010dec31dad64e3eb68b70e10aed9afd2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24204698/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Aim</h4>To retrospectively investigate the changes of SpO2 and respiratory drive in preterm infants at birth after administration of 100% oxygen.<h4>Methods</h4>Respiratory parameters, FiO2 and oximetry of infants <32 weeks gestation before and after receiving FiO2 1.0 were reviewed during continuous positive airway pressure (CPAP) or positive pressure ventilation (PPV).<h4>Results</h4>Results are given as median (IQR) or percentages where appropriate. Suitable recordings were made in 50 infants (GA 27 (26-29) weeks), 17 received CPAP and 33 PPV. SpO2 increased rapidly in the first minute after FiO2 1.0 and remained stable. The duration of FiO2 1.0 tended to be shorter in the CPAP group than in the PPV group (CPAP vs. PPV: 65 (33-105) vs. 100 (40-280) s; p = 0.05), SpO2 >95% occurred more often in PPV group (53% vs. 69%) and lasted longer (70(40-95) vs. 120(50-202) s). In CPAP group, minute volume increased from 134 (76-265) mL/kg/min 1 minute before to 240 (157-370) mL/kg/min (p<0.01) 1 minute after start FiO2 1.0 and remained stable at 2 minutes (252 (135-376) mL/kg/min; ns). The rate of rise to maximum tidal volume increased (from 13.8 (8.0-22.4) mL/kg/s to 18.2 (11.0-27.5) mL/kg/s; p<0.0001) to 18.8 (11.8-27.8) mL/kg/s; ns). In the PPV group respiratory rate increased from 0(0-4) to 9(0-20) at 1 minute (p<0.001) to 23 (0-34) breaths per minute at 2 minutes (p<0.01).<h4>Conclusion</h4>In preterm infants at birth, a rapid increase in oxygenation, resulting from a transient increase to 100% oxygen might improve respiratory drive, but increases the risk for hyperoxia.Jeroen J van VonderenNadia E NarayenFrans J WaltherMelissa L SiewPeter G DavisStuart B HooperArjan B te PasPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 10, p e76898 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeroen J van Vonderen Nadia E Narayen Frans J Walther Melissa L Siew Peter G Davis Stuart B Hooper Arjan B te Pas The administration of 100% oxygen and respiratory drive in very preterm infants at birth.
description	<h4>Aim</h4>To retrospectively investigate the changes of SpO2 and respiratory drive in preterm infants at birth after administration of 100% oxygen.<h4>Methods</h4>Respiratory parameters, FiO2 and oximetry of infants <32 weeks gestation before and after receiving FiO2 1.0 were reviewed during continuous positive airway pressure (CPAP) or positive pressure ventilation (PPV).<h4>Results</h4>Results are given as median (IQR) or percentages where appropriate. Suitable recordings were made in 50 infants (GA 27 (26-29) weeks), 17 received CPAP and 33 PPV. SpO2 increased rapidly in the first minute after FiO2 1.0 and remained stable. The duration of FiO2 1.0 tended to be shorter in the CPAP group than in the PPV group (CPAP vs. PPV: 65 (33-105) vs. 100 (40-280) s; p = 0.05), SpO2 >95% occurred more often in PPV group (53% vs. 69%) and lasted longer (70(40-95) vs. 120(50-202) s). In CPAP group, minute volume increased from 134 (76-265) mL/kg/min 1 minute before to 240 (157-370) mL/kg/min (p<0.01) 1 minute after start FiO2 1.0 and remained stable at 2 minutes (252 (135-376) mL/kg/min; ns). The rate of rise to maximum tidal volume increased (from 13.8 (8.0-22.4) mL/kg/s to 18.2 (11.0-27.5) mL/kg/s; p<0.0001) to 18.8 (11.8-27.8) mL/kg/s; ns). In the PPV group respiratory rate increased from 0(0-4) to 9(0-20) at 1 minute (p<0.001) to 23 (0-34) breaths per minute at 2 minutes (p<0.01).<h4>Conclusion</h4>In preterm infants at birth, a rapid increase in oxygenation, resulting from a transient increase to 100% oxygen might improve respiratory drive, but increases the risk for hyperoxia.
format	article
author	Jeroen J van Vonderen Nadia E Narayen Frans J Walther Melissa L Siew Peter G Davis Stuart B Hooper Arjan B te Pas
author_facet	Jeroen J van Vonderen Nadia E Narayen Frans J Walther Melissa L Siew Peter G Davis Stuart B Hooper Arjan B te Pas
author_sort	Jeroen J van Vonderen
title	The administration of 100% oxygen and respiratory drive in very preterm infants at birth.
title_short	The administration of 100% oxygen and respiratory drive in very preterm infants at birth.
title_full	The administration of 100% oxygen and respiratory drive in very preterm infants at birth.
title_fullStr	The administration of 100% oxygen and respiratory drive in very preterm infants at birth.
title_full_unstemmed	The administration of 100% oxygen and respiratory drive in very preterm infants at birth.
title_sort	administration of 100% oxygen and respiratory drive in very preterm infants at birth.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/010dec31dad64e3eb68b70e10aed9afd
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The administration of 100% oxygen and respiratory drive in very preterm infants at birth.

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