Divergent prion strain evolution driven by PrPC expression level in transgenic mice

PrPC protein plays a key role in prion transmission across species. Here, the authors compare transmission of a representative scrapie isolate to transgenic mice expressing variable levels of the same Prnp allele as the donor sheep, and find divergent strain propagation regulated by PrPCgene dosage.

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Autores principales:	Annick Le Dur, Thanh Lan Laï, Marie-George Stinnakre, Aude Laisné, Nathalie Chenais, Sabine Rakotobe, Bruno Passet, Fabienne Reine, Solange Soulier, Laetitia Herzog, Gaëlle Tilly, Human Rézaei, Vincent Béringue, Jean-Luc Vilotte, Hubert Laude
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/010dfaabcfa2495381f0b8a4b4e912ee
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spelling	oai:doaj.org-article:010dfaabcfa2495381f0b8a4b4e912ee2021-12-02T14:41:59ZDivergent prion strain evolution driven by PrPC expression level in transgenic mice10.1038/ncomms141702041-1723https://doaj.org/article/010dfaabcfa2495381f0b8a4b4e912ee2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14170https://doaj.org/toc/2041-1723PrPC protein plays a key role in prion transmission across species. Here, the authors compare transmission of a representative scrapie isolate to transgenic mice expressing variable levels of the same Prnp allele as the donor sheep, and find divergent strain propagation regulated by PrPCgene dosage.Annick Le DurThanh Lan LaïMarie-George StinnakreAude LaisnéNathalie ChenaisSabine RakotobeBruno PassetFabienne ReineSolange SoulierLaetitia HerzogGaëlle TillyHuman RézaeiVincent BéringueJean-Luc VilotteHubert LaudeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Annick Le Dur Thanh Lan Laï Marie-George Stinnakre Aude Laisné Nathalie Chenais Sabine Rakotobe Bruno Passet Fabienne Reine Solange Soulier Laetitia Herzog Gaëlle Tilly Human Rézaei Vincent Béringue Jean-Luc Vilotte Hubert Laude Divergent prion strain evolution driven by PrPC expression level in transgenic mice
description	PrPC protein plays a key role in prion transmission across species. Here, the authors compare transmission of a representative scrapie isolate to transgenic mice expressing variable levels of the same Prnp allele as the donor sheep, and find divergent strain propagation regulated by PrPCgene dosage.
format	article
author	Annick Le Dur Thanh Lan Laï Marie-George Stinnakre Aude Laisné Nathalie Chenais Sabine Rakotobe Bruno Passet Fabienne Reine Solange Soulier Laetitia Herzog Gaëlle Tilly Human Rézaei Vincent Béringue Jean-Luc Vilotte Hubert Laude
author_facet	Annick Le Dur Thanh Lan Laï Marie-George Stinnakre Aude Laisné Nathalie Chenais Sabine Rakotobe Bruno Passet Fabienne Reine Solange Soulier Laetitia Herzog Gaëlle Tilly Human Rézaei Vincent Béringue Jean-Luc Vilotte Hubert Laude
author_sort	Annick Le Dur
title	Divergent prion strain evolution driven by PrPC expression level in transgenic mice
title_short	Divergent prion strain evolution driven by PrPC expression level in transgenic mice
title_full	Divergent prion strain evolution driven by PrPC expression level in transgenic mice
title_fullStr	Divergent prion strain evolution driven by PrPC expression level in transgenic mice
title_full_unstemmed	Divergent prion strain evolution driven by PrPC expression level in transgenic mice
title_sort	divergent prion strain evolution driven by prpc expression level in transgenic mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/010dfaabcfa2495381f0b8a4b4e912ee
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Divergent prion strain evolution driven by PrPC expression level in transgenic mice

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