Replenishing the Aged Brains: Targeting Oligodendrocytes and Myelination?

Aging affects almost all the aspects of brain functions, but the mechanisms remain largely undefined. Increasing number of literatures have manifested the important role of glial cells in regulating the aging process. Oligodendroglial lineage cell is a major type of glia in central nervous system (C...

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Autores principales:	Xi Zhang, Nanxin Huang, Lan Xiao, Fei Wang, Tao Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	oligodendrocyte OPC myelinogenesis aging neurofunctional decline Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/010fd8995de44d008fc6088ae8d4600d
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spelling	oai:doaj.org-article:010fd8995de44d008fc6088ae8d4600d2021-12-01T02:00:42ZReplenishing the Aged Brains: Targeting Oligodendrocytes and Myelination?1663-436510.3389/fnagi.2021.760200https://doaj.org/article/010fd8995de44d008fc6088ae8d4600d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.760200/fullhttps://doaj.org/toc/1663-4365Aging affects almost all the aspects of brain functions, but the mechanisms remain largely undefined. Increasing number of literatures have manifested the important role of glial cells in regulating the aging process. Oligodendroglial lineage cell is a major type of glia in central nervous system (CNS), composed of mature oligodendrocytes (OLs), and oligodendroglia precursor cells (OPCs). OLs produce myelin sheaths that insulate axons and provide metabolic support to meet the energy demand. OPCs maintain the population throughout lifetime with the abilities to proliferate and differentiate into OLs. Increasing evidence has shown that oligodendroglial cells display active dynamics in adult and aging CNS, which is extensively involved in age-related brain function decline in the elderly. In this review, we summarized present knowledge about dynamic changes of oligodendroglial lineage cells during normal aging and discussed their potential roles in age-related functional decline. Especially, focused on declined myelinogenesis during aging and underlying mechanisms. Clarifying those oligodendroglial changes and their effects on neurofunctional decline may provide new insights in understanding aging associated brain function declines.Xi ZhangXi ZhangNanxin HuangLan XiaoFei WangTao LiFrontiers Media S.A.articleoligodendrocyteOPCmyelinogenesisagingneurofunctional declineNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oligodendrocyte OPC myelinogenesis aging neurofunctional decline Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	oligodendrocyte OPC myelinogenesis aging neurofunctional decline Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Xi Zhang Xi Zhang Nanxin Huang Lan Xiao Fei Wang Tao Li Replenishing the Aged Brains: Targeting Oligodendrocytes and Myelination?
description	Aging affects almost all the aspects of brain functions, but the mechanisms remain largely undefined. Increasing number of literatures have manifested the important role of glial cells in regulating the aging process. Oligodendroglial lineage cell is a major type of glia in central nervous system (CNS), composed of mature oligodendrocytes (OLs), and oligodendroglia precursor cells (OPCs). OLs produce myelin sheaths that insulate axons and provide metabolic support to meet the energy demand. OPCs maintain the population throughout lifetime with the abilities to proliferate and differentiate into OLs. Increasing evidence has shown that oligodendroglial cells display active dynamics in adult and aging CNS, which is extensively involved in age-related brain function decline in the elderly. In this review, we summarized present knowledge about dynamic changes of oligodendroglial lineage cells during normal aging and discussed their potential roles in age-related functional decline. Especially, focused on declined myelinogenesis during aging and underlying mechanisms. Clarifying those oligodendroglial changes and their effects on neurofunctional decline may provide new insights in understanding aging associated brain function declines.
format	article
author	Xi Zhang Xi Zhang Nanxin Huang Lan Xiao Fei Wang Tao Li
author_facet	Xi Zhang Xi Zhang Nanxin Huang Lan Xiao Fei Wang Tao Li
author_sort	Xi Zhang
title	Replenishing the Aged Brains: Targeting Oligodendrocytes and Myelination?
title_short	Replenishing the Aged Brains: Targeting Oligodendrocytes and Myelination?
title_full	Replenishing the Aged Brains: Targeting Oligodendrocytes and Myelination?
title_fullStr	Replenishing the Aged Brains: Targeting Oligodendrocytes and Myelination?
title_full_unstemmed	Replenishing the Aged Brains: Targeting Oligodendrocytes and Myelination?
title_sort	replenishing the aged brains: targeting oligodendrocytes and myelination?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/010fd8995de44d008fc6088ae8d4600d
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Replenishing the Aged Brains: Targeting Oligodendrocytes and Myelination?

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