Lipid analogs reveal features critical for hemolysis and diminish granadaene mediated Group B Streptococcus infection

Lipid analogs reveal features critical for hemolysis and diminish granadaene mediated Group B Streptococcus infection

Granadaene, produced by Group B Streptococcus (GBS), is a long polyene lipid involved in cellular toxicity and hemolytic activity. Here, the authors synthesize and characterize granadaene-like compounds and show that a non-toxic analog diminishes GBS infection in mice when incorporated into a vaccin...

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Autores principales: Blair Armistead, Pilar Herrero-Foncubierta, Michelle Coleman, Phoenicia Quach, Christopher Whidbey, Jose Justicia, Ruben Tapia, Raquel Casares, Alba Millán, Ali Haidour, Javier Rodriguez Granger, Jay Vornhagen, Verónica Santana-Ufret, Sean Merillat, Kristina Adams Waldorf, Juan Manuel Cuerva, Lakshmi Rajagopal
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/01154be08c1f487dac280617b8f79212
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Sumario:Granadaene, produced by Group B Streptococcus (GBS), is a long polyene lipid involved in cellular toxicity and hemolytic activity. Here, the authors synthesize and characterize granadaene-like compounds and show that a non-toxic analog diminishes GBS infection in mice when incorporated into a vaccine formulation.

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