Lipid analogs reveal features critical for hemolysis and diminish granadaene mediated Group B Streptococcus infection

Granadaene, produced by Group B Streptococcus (GBS), is a long polyene lipid involved in cellular toxicity and hemolytic activity. Here, the authors synthesize and characterize granadaene-like compounds and show that a non-toxic analog diminishes GBS infection in mice when incorporated into a vaccin...

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Autores principales:	Blair Armistead, Pilar Herrero-Foncubierta, Michelle Coleman, Phoenicia Quach, Christopher Whidbey, Jose Justicia, Ruben Tapia, Raquel Casares, Alba Millán, Ali Haidour, Javier Rodriguez Granger, Jay Vornhagen, Verónica Santana-Ufret, Sean Merillat, Kristina Adams Waldorf, Juan Manuel Cuerva, Lakshmi Rajagopal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/01154be08c1f487dac280617b8f79212
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spelling	oai:doaj.org-article:01154be08c1f487dac280617b8f792122021-12-02T15:39:22ZLipid analogs reveal features critical for hemolysis and diminish granadaene mediated Group B Streptococcus infection10.1038/s41467-020-15282-02041-1723https://doaj.org/article/01154be08c1f487dac280617b8f792122020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15282-0https://doaj.org/toc/2041-1723Granadaene, produced by Group B Streptococcus (GBS), is a long polyene lipid involved in cellular toxicity and hemolytic activity. Here, the authors synthesize and characterize granadaene-like compounds and show that a non-toxic analog diminishes GBS infection in mice when incorporated into a vaccine formulation.Blair ArmisteadPilar Herrero-FoncubiertaMichelle ColemanPhoenicia QuachChristopher WhidbeyJose JusticiaRuben TapiaRaquel CasaresAlba MillánAli HaidourJavier Rodriguez GrangerJay VornhagenVerónica Santana-UfretSean MerillatKristina Adams WaldorfJuan Manuel CuervaLakshmi RajagopalNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Blair Armistead Pilar Herrero-Foncubierta Michelle Coleman Phoenicia Quach Christopher Whidbey Jose Justicia Ruben Tapia Raquel Casares Alba Millán Ali Haidour Javier Rodriguez Granger Jay Vornhagen Verónica Santana-Ufret Sean Merillat Kristina Adams Waldorf Juan Manuel Cuerva Lakshmi Rajagopal Lipid analogs reveal features critical for hemolysis and diminish granadaene mediated Group B Streptococcus infection
description	Granadaene, produced by Group B Streptococcus (GBS), is a long polyene lipid involved in cellular toxicity and hemolytic activity. Here, the authors synthesize and characterize granadaene-like compounds and show that a non-toxic analog diminishes GBS infection in mice when incorporated into a vaccine formulation.
format	article
author	Blair Armistead Pilar Herrero-Foncubierta Michelle Coleman Phoenicia Quach Christopher Whidbey Jose Justicia Ruben Tapia Raquel Casares Alba Millán Ali Haidour Javier Rodriguez Granger Jay Vornhagen Verónica Santana-Ufret Sean Merillat Kristina Adams Waldorf Juan Manuel Cuerva Lakshmi Rajagopal
author_facet	Blair Armistead Pilar Herrero-Foncubierta Michelle Coleman Phoenicia Quach Christopher Whidbey Jose Justicia Ruben Tapia Raquel Casares Alba Millán Ali Haidour Javier Rodriguez Granger Jay Vornhagen Verónica Santana-Ufret Sean Merillat Kristina Adams Waldorf Juan Manuel Cuerva Lakshmi Rajagopal
author_sort	Blair Armistead
title	Lipid analogs reveal features critical for hemolysis and diminish granadaene mediated Group B Streptococcus infection
title_short	Lipid analogs reveal features critical for hemolysis and diminish granadaene mediated Group B Streptococcus infection
title_full	Lipid analogs reveal features critical for hemolysis and diminish granadaene mediated Group B Streptococcus infection
title_fullStr	Lipid analogs reveal features critical for hemolysis and diminish granadaene mediated Group B Streptococcus infection
title_full_unstemmed	Lipid analogs reveal features critical for hemolysis and diminish granadaene mediated Group B Streptococcus infection
title_sort	lipid analogs reveal features critical for hemolysis and diminish granadaene mediated group b streptococcus infection
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/01154be08c1f487dac280617b8f79212
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Lipid analogs reveal features critical for hemolysis and diminish granadaene mediated Group B Streptococcus infection

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