Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus
Ciliary defects and obesity has been associated, but the underlying mechanism is unclear. Here, the authors show that inhibition of ciliogenesis in POMC neurons during development results in lysosomal protein degradation-dependent axonal disruption and adult obesity in mice.
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Nature Portfolio
2020
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oai:doaj.org-article:0116400a6a59446083a8f46c10ce075d2021-12-02T15:37:19ZPrimary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus10.1038/s41467-020-19638-42041-1723https://doaj.org/article/0116400a6a59446083a8f46c10ce075d2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19638-4https://doaj.org/toc/2041-1723Ciliary defects and obesity has been associated, but the underlying mechanism is unclear. Here, the authors show that inhibition of ciliogenesis in POMC neurons during development results in lysosomal protein degradation-dependent axonal disruption and adult obesity in mice.Chan Hee LeeDo Kyeong SongChae Beom ParkJeewon ChoiGil Myoung KangSung Hoon ShinIjoo KwonSoyoung ParkSeongjun KimJi Ye KimHong DuguJae Woo ParkJong Han ChoiSe Hee MinJong-Woo SohnMin-Seon KimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Chan Hee Lee Do Kyeong Song Chae Beom Park Jeewon Choi Gil Myoung Kang Sung Hoon Shin Ijoo Kwon Soyoung Park Seongjun Kim Ji Ye Kim Hong Dugu Jae Woo Park Jong Han Choi Se Hee Min Jong-Woo Sohn Min-Seon Kim Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus |
| description |
Ciliary defects and obesity has been associated, but the underlying mechanism is unclear. Here, the authors show that inhibition of ciliogenesis in POMC neurons during development results in lysosomal protein degradation-dependent axonal disruption and adult obesity in mice. |
| format |
article |
| author |
Chan Hee Lee Do Kyeong Song Chae Beom Park Jeewon Choi Gil Myoung Kang Sung Hoon Shin Ijoo Kwon Soyoung Park Seongjun Kim Ji Ye Kim Hong Dugu Jae Woo Park Jong Han Choi Se Hee Min Jong-Woo Sohn Min-Seon Kim |
| author_facet |
Chan Hee Lee Do Kyeong Song Chae Beom Park Jeewon Choi Gil Myoung Kang Sung Hoon Shin Ijoo Kwon Soyoung Park Seongjun Kim Ji Ye Kim Hong Dugu Jae Woo Park Jong Han Choi Se Hee Min Jong-Woo Sohn Min-Seon Kim |
| author_sort |
Chan Hee Lee |
| title |
Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus |
| title_short |
Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus |
| title_full |
Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus |
| title_fullStr |
Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus |
| title_full_unstemmed |
Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus |
| title_sort |
primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/0116400a6a59446083a8f46c10ce075d |
| work_keys_str_mv |
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| _version_ |
1718386211545939968 |