Engineering prokaryotic channels for control of mammalian tissue excitability

Restoring lost excitability of injured tissue is a paramount of regenerative medicine. By using a combined expression of bacterial voltage-gated Na+ channel, Kir2.1, and connexin-43 in non-excitable human fibroblasts, here the authors generate excitable cells that rescue action potential conduction...

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Auteurs principaux:	Hung X. Nguyen, Robert D. Kirkton, Nenad Bursac
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/01169a26b7fb41869b421987bafb38d4
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id	oai:doaj.org-article:01169a26b7fb41869b421987bafb38d4
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spelling	oai:doaj.org-article:01169a26b7fb41869b421987bafb38d42021-12-02T17:33:07ZEngineering prokaryotic channels for control of mammalian tissue excitability10.1038/ncomms131322041-1723https://doaj.org/article/01169a26b7fb41869b421987bafb38d42016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13132https://doaj.org/toc/2041-1723Restoring lost excitability of injured tissue is a paramount of regenerative medicine. By using a combined expression of bacterial voltage-gated Na+ channel, Kir2.1, and connexin-43 in non-excitable human fibroblasts, here the authors generate excitable cells that rescue action potential conduction in an in vitromodel of cardiac fibrosis.Hung X. NguyenRobert D. KirktonNenad BursacNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hung X. Nguyen Robert D. Kirkton Nenad Bursac Engineering prokaryotic channels for control of mammalian tissue excitability
description	Restoring lost excitability of injured tissue is a paramount of regenerative medicine. By using a combined expression of bacterial voltage-gated Na+ channel, Kir2.1, and connexin-43 in non-excitable human fibroblasts, here the authors generate excitable cells that rescue action potential conduction in an in vitromodel of cardiac fibrosis.
format	article
author	Hung X. Nguyen Robert D. Kirkton Nenad Bursac
author_facet	Hung X. Nguyen Robert D. Kirkton Nenad Bursac
author_sort	Hung X. Nguyen
title	Engineering prokaryotic channels for control of mammalian tissue excitability
title_short	Engineering prokaryotic channels for control of mammalian tissue excitability
title_full	Engineering prokaryotic channels for control of mammalian tissue excitability
title_fullStr	Engineering prokaryotic channels for control of mammalian tissue excitability
title_full_unstemmed	Engineering prokaryotic channels for control of mammalian tissue excitability
title_sort	engineering prokaryotic channels for control of mammalian tissue excitability
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/01169a26b7fb41869b421987bafb38d4
work_keys_str_mv	AT hungxnguyen engineeringprokaryoticchannelsforcontrolofmammaliantissueexcitability AT robertdkirkton engineeringprokaryoticchannelsforcontrolofmammaliantissueexcitability AT nenadbursac engineeringprokaryoticchannelsforcontrolofmammaliantissueexcitability
_version_	1718380040103657472

Engineering prokaryotic channels for control of mammalian tissue excitability

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