Engineering prokaryotic channels for control of mammalian tissue excitability

Restoring lost excitability of injured tissue is a paramount of regenerative medicine. By using a combined expression of bacterial voltage-gated Na+ channel, Kir2.1, and connexin-43 in non-excitable human fibroblasts, here the authors generate excitable cells that rescue action potential conduction...

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Auteurs principaux: Hung X. Nguyen, Robert D. Kirkton, Nenad Bursac
Format: article
Langue:EN
Publié: Nature Portfolio 2016
Sujets:
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Accès en ligne:https://doaj.org/article/01169a26b7fb41869b421987bafb38d4
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