In-situ Electrospinning for Intestinal Hemostasis

Tongtong Zhou,1,* Yaozhong Wang,2,* Fengcai Lei,3 Jing Yu4 1Collaborative Innovation Center for Nanomaterials & Devices, College of Physics, Qingdao University, Qingdao 266071, People’s Republic of China; 2Department of Oral and Maxillo-Facial Surgery, Qingdao Stomatological Hospit...

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Autores principales:	Zhou T, Wang Y, Lei F, Yu J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	electrospinning hemostasis nanofibers Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/011945dcbee0491ea21938b23b209ffa
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spelling	oai:doaj.org-article:011945dcbee0491ea21938b23b209ffa2021-12-02T10:00:47ZIn-situ Electrospinning for Intestinal Hemostasis1178-2013https://doaj.org/article/011945dcbee0491ea21938b23b209ffa2020-05-01T00:00:00Zhttps://www.dovepress.com/in-situ-electrospinning-for-intestinal-hemostasis-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Tongtong Zhou,1,* Yaozhong Wang,2,* Fengcai Lei,3 Jing Yu4 1Collaborative Innovation Center for Nanomaterials & Devices, College of Physics, Qingdao University, Qingdao 266071, People’s Republic of China; 2Department of Oral and Maxillo-Facial Surgery, Qingdao Stomatological Hospital, Qingdao, People’s Republic of China; 3College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, People’s Republic of China; 4School of Physics and Electronics, Shandong Normal University, Jinan 250014, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fengcai Lei; Jing Yu Email fengcai9213@126.com; yujing1608@126.comIntroduction: During routine surgery, rapid hemostasis, especially the rapid hemostasis of internal organs, is very important. The emergence of in-situ electrospinning technology has fundamentally solved this problem. It exhibits a high speed of hemostasis, and no bleeding occurs after surgery. Thus, it is of great significance. The use of sutures in some human organs, such as the intestines and bladder, is inadequate because fluid leakage occurs due to the presence of pinholes.Methods: Three types of large intestine wounds with an opening of about 1 cm were investigated. They were untreated, treated by needle and threaded, and treated by hand-held electrospinning, respectively.Results: The results show that hand-held electrospinning technique effectively prevented the exudation of fluids in the intestinal tract. The average diameter of the nanofibrous membrane was about 0.5 μm with hole of several micrometers. It can be elongated 90% without breakage. The hand-held electrospinning device could be used with nitrile gloves, preventing the risk of infection caused by exposed hands.Discussion: This work can provide a reference for future animal experiments and clinical experiments. However, safety should be investigated before application.Keywords: electrospinning, hemostasis, nanofibersZhou TWang YLei FYu JDove Medical PressarticleelectrospinninghemostasisnanofibersMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 3869-3875 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	electrospinning hemostasis nanofibers Medicine (General) R5-920
spellingShingle	electrospinning hemostasis nanofibers Medicine (General) R5-920 Zhou T Wang Y Lei F Yu J In-situ Electrospinning for Intestinal Hemostasis
description	Tongtong Zhou,1,* Yaozhong Wang,2,* Fengcai Lei,3 Jing Yu4 1Collaborative Innovation Center for Nanomaterials & Devices, College of Physics, Qingdao University, Qingdao 266071, People’s Republic of China; 2Department of Oral and Maxillo-Facial Surgery, Qingdao Stomatological Hospital, Qingdao, People’s Republic of China; 3College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, People’s Republic of China; 4School of Physics and Electronics, Shandong Normal University, Jinan 250014, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fengcai Lei; Jing Yu Email fengcai9213@126.com; yujing1608@126.comIntroduction: During routine surgery, rapid hemostasis, especially the rapid hemostasis of internal organs, is very important. The emergence of in-situ electrospinning technology has fundamentally solved this problem. It exhibits a high speed of hemostasis, and no bleeding occurs after surgery. Thus, it is of great significance. The use of sutures in some human organs, such as the intestines and bladder, is inadequate because fluid leakage occurs due to the presence of pinholes.Methods: Three types of large intestine wounds with an opening of about 1 cm were investigated. They were untreated, treated by needle and threaded, and treated by hand-held electrospinning, respectively.Results: The results show that hand-held electrospinning technique effectively prevented the exudation of fluids in the intestinal tract. The average diameter of the nanofibrous membrane was about 0.5 μm with hole of several micrometers. It can be elongated 90% without breakage. The hand-held electrospinning device could be used with nitrile gloves, preventing the risk of infection caused by exposed hands.Discussion: This work can provide a reference for future animal experiments and clinical experiments. However, safety should be investigated before application.Keywords: electrospinning, hemostasis, nanofibers
format	article
author	Zhou T Wang Y Lei F Yu J
author_facet	Zhou T Wang Y Lei F Yu J
author_sort	Zhou T
title	In-situ Electrospinning for Intestinal Hemostasis
title_short	In-situ Electrospinning for Intestinal Hemostasis
title_full	In-situ Electrospinning for Intestinal Hemostasis
title_fullStr	In-situ Electrospinning for Intestinal Hemostasis
title_full_unstemmed	In-situ Electrospinning for Intestinal Hemostasis
title_sort	in-situ electrospinning for intestinal hemostasis
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/011945dcbee0491ea21938b23b209ffa
work_keys_str_mv	AT zhout insituelectrospinningforintestinalhemostasis AT wangy insituelectrospinningforintestinalhemostasis AT leif insituelectrospinningforintestinalhemostasis AT yuj insituelectrospinningforintestinalhemostasis
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In-situ Electrospinning for Intestinal Hemostasis

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