Liver-targeted liposomes for codelivery of curcumin and combretastatin A4 phosphate: preparation, characterization, and antitumor effects

Hong Jiang,1,* Zhi-Peng Li,1,* Gui-Xiang Tian,1,* Rui-Yan Pan,1 Chong-Mei Xu,2 Bo Zhang,2 Jing-liang Wu1 1School of Bioscience and Technology, Weifang Medical University, Weifang, Shandong, China; 2School of Pharmacy, Weifang Medical University, Weifang, Shandong, China *These authors contributed...

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Autores principales:	Jiang H, Li ZP, Tian GX, Pan RY, Xu CM, Zhang B, Wu JL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Liver-targeted LPs curcumin combretastatin A4 phosphate combination therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/01217ca022574beb855971fa412a72ba
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spelling	oai:doaj.org-article:01217ca022574beb855971fa412a72ba2021-12-02T05:21:01ZLiver-targeted liposomes for codelivery of curcumin and combretastatin A4 phosphate: preparation, characterization, and antitumor effects1178-2013https://doaj.org/article/01217ca022574beb855971fa412a72ba2019-03-01T00:00:00Zhttps://www.dovepress.com/liver-targeted-liposomes-for-codelivery-of-curcumin-and-combretastatin-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Hong Jiang,1,* Zhi-Peng Li,1,* Gui-Xiang Tian,1,* Rui-Yan Pan,1 Chong-Mei Xu,2 Bo Zhang,2 Jing-liang Wu1 1School of Bioscience and Technology, Weifang Medical University, Weifang, Shandong, China; 2School of Pharmacy, Weifang Medical University, Weifang, Shandong, China *These authors contributed equally to this work Background: Recent efforts have been focused on combining two or more therapeutic approaches with different mechanisms to enhance antitumor therapy. Moreover, nanosize drug-delivery systems for codelivering two drugs with proapoptotic and antiangiogenic activities have exhibited great potential in efficient treatment of cancers. Methods: Glycyrrhetinic acid (GA)–modified liposomes (GA LPs) for liver-targeted codelivery of curcumin (Cur) and combretastatin A4 phosphate (CA4P) were prepared and characterized. In vitro cellular uptake, cytotoxicity, cell migration, in vivo biodistribution, antitumor activity, and histopathological studies were performed. Results: Compared with unmodified LPs (Cur-CA4P LPs), Cur-CA4P/GA LPs were taken up effectively by human hepatocellular carcinoma cells (BEL-7402) and showed higher cytotoxicity than free drugs. In vivo real-time near-infrared fluorescence–imaging results indicated that GA-targeted LPs increased accumulation in the tumor region. Moreover, Cur-CA4P/GA LPs showed stronger inhibition of tumor proliferation than Cur, Cur + CA4P, and Cur-CA4P LPs in vivo antitumor studies, which was also verified by H&E staining. Conclusion: GA-modified LPs can serve as a promising nanocarrier for liver-targeted co-delivery of antitumor drugs against hepatocellular carcinoma. Keywords: liver-targeted, LPs, curcumin, combretastatin A4 phosphate, combination therapyJiang HLi ZPTian GXPan RYXu CMZhang BWu JLDove Medical PressarticleLiver-targetedLPscurcumincombretastatin A4 phosphatecombination therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 1789-1804 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Liver-targeted LPs curcumin combretastatin A4 phosphate combination therapy Medicine (General) R5-920
spellingShingle	Liver-targeted LPs curcumin combretastatin A4 phosphate combination therapy Medicine (General) R5-920 Jiang H Li ZP Tian GX Pan RY Xu CM Zhang B Wu JL Liver-targeted liposomes for codelivery of curcumin and combretastatin A4 phosphate: preparation, characterization, and antitumor effects
description	Hong Jiang,1,* Zhi-Peng Li,1,* Gui-Xiang Tian,1,* Rui-Yan Pan,1 Chong-Mei Xu,2 Bo Zhang,2 Jing-liang Wu1 1School of Bioscience and Technology, Weifang Medical University, Weifang, Shandong, China; 2School of Pharmacy, Weifang Medical University, Weifang, Shandong, China *These authors contributed equally to this work Background: Recent efforts have been focused on combining two or more therapeutic approaches with different mechanisms to enhance antitumor therapy. Moreover, nanosize drug-delivery systems for codelivering two drugs with proapoptotic and antiangiogenic activities have exhibited great potential in efficient treatment of cancers. Methods: Glycyrrhetinic acid (GA)–modified liposomes (GA LPs) for liver-targeted codelivery of curcumin (Cur) and combretastatin A4 phosphate (CA4P) were prepared and characterized. In vitro cellular uptake, cytotoxicity, cell migration, in vivo biodistribution, antitumor activity, and histopathological studies were performed. Results: Compared with unmodified LPs (Cur-CA4P LPs), Cur-CA4P/GA LPs were taken up effectively by human hepatocellular carcinoma cells (BEL-7402) and showed higher cytotoxicity than free drugs. In vivo real-time near-infrared fluorescence–imaging results indicated that GA-targeted LPs increased accumulation in the tumor region. Moreover, Cur-CA4P/GA LPs showed stronger inhibition of tumor proliferation than Cur, Cur + CA4P, and Cur-CA4P LPs in vivo antitumor studies, which was also verified by H&E staining. Conclusion: GA-modified LPs can serve as a promising nanocarrier for liver-targeted co-delivery of antitumor drugs against hepatocellular carcinoma. Keywords: liver-targeted, LPs, curcumin, combretastatin A4 phosphate, combination therapy
format	article
author	Jiang H Li ZP Tian GX Pan RY Xu CM Zhang B Wu JL
author_facet	Jiang H Li ZP Tian GX Pan RY Xu CM Zhang B Wu JL
author_sort	Jiang H
title	Liver-targeted liposomes for codelivery of curcumin and combretastatin A4 phosphate: preparation, characterization, and antitumor effects
title_short	Liver-targeted liposomes for codelivery of curcumin and combretastatin A4 phosphate: preparation, characterization, and antitumor effects
title_full	Liver-targeted liposomes for codelivery of curcumin and combretastatin A4 phosphate: preparation, characterization, and antitumor effects
title_fullStr	Liver-targeted liposomes for codelivery of curcumin and combretastatin A4 phosphate: preparation, characterization, and antitumor effects
title_full_unstemmed	Liver-targeted liposomes for codelivery of curcumin and combretastatin A4 phosphate: preparation, characterization, and antitumor effects
title_sort	liver-targeted liposomes for codelivery of curcumin and combretastatin a4 phosphate: preparation, characterization, and antitumor effects
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/01217ca022574beb855971fa412a72ba
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Liver-targeted liposomes for codelivery of curcumin and combretastatin A4 phosphate: preparation, characterization, and antitumor effects

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