Partial indoor residual spraying with pirimiphos-methyl as an effective and cost-saving measure for the control of Anopheles gambiae s.l. in northern Ghana
Abstract The scale up of indoor residual spraying (IRS) and insecticide treated nets have contributed significantly to global reductions in malaria prevalence over the last two decades. However, widespread pyrethroid resistance has necessitated the use of new and more expensive insecticides for IRS....
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/0121c373b9ea44a58a8d894a1ff100bf |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:0121c373b9ea44a58a8d894a1ff100bf |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:0121c373b9ea44a58a8d894a1ff100bf2021-12-02T17:19:15ZPartial indoor residual spraying with pirimiphos-methyl as an effective and cost-saving measure for the control of Anopheles gambiae s.l. in northern Ghana10.1038/s41598-021-97138-12045-2322https://doaj.org/article/0121c373b9ea44a58a8d894a1ff100bf2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97138-1https://doaj.org/toc/2045-2322Abstract The scale up of indoor residual spraying (IRS) and insecticide treated nets have contributed significantly to global reductions in malaria prevalence over the last two decades. However, widespread pyrethroid resistance has necessitated the use of new and more expensive insecticides for IRS. Partial IRS with pirimiphos-methyl in experimental huts and houses in a village-wide trial was evaluated against Anopheles gambiae s.l. in northern Ghana. Four different scenarios in which either only the top or bottom half of the walls of experimental huts were sprayed, with or without also spraying the ceiling were compared. Mortality of An. gambiae s.l. on partially sprayed walls was compared with the standard procedures in which all walls and ceiling surfaces are sprayed. A small-scale trial was then conducted to assess the effectiveness, feasibility, and cost of spraying only the upper walls and ceiling as compared to full IRS and no spraying in northern Ghana. Human landing catches were conducted to estimate entomological indices and determine the effectiveness of partial IRS. An established transmission dynamics model was parameterized by an analysis of the experimental hut data and used to predict the epidemiological impact and cost effectiveness of partial IRS for malaria control in northern Ghana. In the experimental huts, partial IRS of the top (IRR 0.89, p = 0.13) or bottom (IRR 0.90, p = 0.15) half of walls and the ceiling was not significantly less effective than full IRS in terms of mosquito mortality. In the village trial, the annual entomological inoculation rate was higher for the unsprayed control (217 infective bites/person/year (ib/p/yr)) compared with the fully and partially sprayed sites, with 28 and 38 ib/p/yr, respectively. The transmission model predicts that the efficacy of partial IRS against all-age prevalence of malaria after six months would be broadly equivalent to a full IRS campaign in which 40% reduction is expected relative to no spray campaign. At scale, partial IRS in northern Ghana would have resulted in a 33% cost savings ($496,426) that would enable spraying of 36,000 additional rooms. These findings suggest that partial IRS is an effective, feasible, and cost saving approach to IRS that could be adopted to sustain and expand implementation of this key malaria control intervention.Sylvester ColemanYemane YihdegoEllie Sherrard-SmithChurcher S. ThomasDereje DengelaRichard M. OxboroughSamuel K. DadzieDaniel BoakyeFrank GyamfiKwasi Obiri-DansoBen JohnsLilly V. SiemsBradford LucasJon Eric TongrenSixte ZigirumugabeDominic DeryChristen FornadelKristen GeorgeAllison BelemvireJenny CarlsonSeth R. IrishJennifer S. ArmisteadAklilu SeyoumNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Sylvester Coleman Yemane Yihdego Ellie Sherrard-Smith Churcher S. Thomas Dereje Dengela Richard M. Oxborough Samuel K. Dadzie Daniel Boakye Frank Gyamfi Kwasi Obiri-Danso Ben Johns Lilly V. Siems Bradford Lucas Jon Eric Tongren Sixte Zigirumugabe Dominic Dery Christen Fornadel Kristen George Allison Belemvire Jenny Carlson Seth R. Irish Jennifer S. Armistead Aklilu Seyoum Partial indoor residual spraying with pirimiphos-methyl as an effective and cost-saving measure for the control of Anopheles gambiae s.l. in northern Ghana |
| description |
Abstract The scale up of indoor residual spraying (IRS) and insecticide treated nets have contributed significantly to global reductions in malaria prevalence over the last two decades. However, widespread pyrethroid resistance has necessitated the use of new and more expensive insecticides for IRS. Partial IRS with pirimiphos-methyl in experimental huts and houses in a village-wide trial was evaluated against Anopheles gambiae s.l. in northern Ghana. Four different scenarios in which either only the top or bottom half of the walls of experimental huts were sprayed, with or without also spraying the ceiling were compared. Mortality of An. gambiae s.l. on partially sprayed walls was compared with the standard procedures in which all walls and ceiling surfaces are sprayed. A small-scale trial was then conducted to assess the effectiveness, feasibility, and cost of spraying only the upper walls and ceiling as compared to full IRS and no spraying in northern Ghana. Human landing catches were conducted to estimate entomological indices and determine the effectiveness of partial IRS. An established transmission dynamics model was parameterized by an analysis of the experimental hut data and used to predict the epidemiological impact and cost effectiveness of partial IRS for malaria control in northern Ghana. In the experimental huts, partial IRS of the top (IRR 0.89, p = 0.13) or bottom (IRR 0.90, p = 0.15) half of walls and the ceiling was not significantly less effective than full IRS in terms of mosquito mortality. In the village trial, the annual entomological inoculation rate was higher for the unsprayed control (217 infective bites/person/year (ib/p/yr)) compared with the fully and partially sprayed sites, with 28 and 38 ib/p/yr, respectively. The transmission model predicts that the efficacy of partial IRS against all-age prevalence of malaria after six months would be broadly equivalent to a full IRS campaign in which 40% reduction is expected relative to no spray campaign. At scale, partial IRS in northern Ghana would have resulted in a 33% cost savings ($496,426) that would enable spraying of 36,000 additional rooms. These findings suggest that partial IRS is an effective, feasible, and cost saving approach to IRS that could be adopted to sustain and expand implementation of this key malaria control intervention. |
| format |
article |
| author |
Sylvester Coleman Yemane Yihdego Ellie Sherrard-Smith Churcher S. Thomas Dereje Dengela Richard M. Oxborough Samuel K. Dadzie Daniel Boakye Frank Gyamfi Kwasi Obiri-Danso Ben Johns Lilly V. Siems Bradford Lucas Jon Eric Tongren Sixte Zigirumugabe Dominic Dery Christen Fornadel Kristen George Allison Belemvire Jenny Carlson Seth R. Irish Jennifer S. Armistead Aklilu Seyoum |
| author_facet |
Sylvester Coleman Yemane Yihdego Ellie Sherrard-Smith Churcher S. Thomas Dereje Dengela Richard M. Oxborough Samuel K. Dadzie Daniel Boakye Frank Gyamfi Kwasi Obiri-Danso Ben Johns Lilly V. Siems Bradford Lucas Jon Eric Tongren Sixte Zigirumugabe Dominic Dery Christen Fornadel Kristen George Allison Belemvire Jenny Carlson Seth R. Irish Jennifer S. Armistead Aklilu Seyoum |
| author_sort |
Sylvester Coleman |
| title |
Partial indoor residual spraying with pirimiphos-methyl as an effective and cost-saving measure for the control of Anopheles gambiae s.l. in northern Ghana |
| title_short |
Partial indoor residual spraying with pirimiphos-methyl as an effective and cost-saving measure for the control of Anopheles gambiae s.l. in northern Ghana |
| title_full |
Partial indoor residual spraying with pirimiphos-methyl as an effective and cost-saving measure for the control of Anopheles gambiae s.l. in northern Ghana |
| title_fullStr |
Partial indoor residual spraying with pirimiphos-methyl as an effective and cost-saving measure for the control of Anopheles gambiae s.l. in northern Ghana |
| title_full_unstemmed |
Partial indoor residual spraying with pirimiphos-methyl as an effective and cost-saving measure for the control of Anopheles gambiae s.l. in northern Ghana |
| title_sort |
partial indoor residual spraying with pirimiphos-methyl as an effective and cost-saving measure for the control of anopheles gambiae s.l. in northern ghana |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/0121c373b9ea44a58a8d894a1ff100bf |
| work_keys_str_mv |
AT sylvestercoleman partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT yemaneyihdego partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT elliesherrardsmith partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT churchersthomas partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT derejedengela partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT richardmoxborough partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT samuelkdadzie partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT danielboakye partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT frankgyamfi partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT kwasiobiridanso partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT benjohns partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT lillyvsiems partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT bradfordlucas partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT jonerictongren partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT sixtezigirumugabe partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT dominicdery partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT christenfornadel partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT kristengeorge partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT allisonbelemvire partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT jennycarlson partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT sethrirish partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT jennifersarmistead partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana AT akliluseyoum partialindoorresidualsprayingwithpirimiphosmethylasaneffectiveandcostsavingmeasureforthecontrolofanophelesgambiaeslinnorthernghana |
| _version_ |
1718381005763510272 |