Poly(A) inclusive RNA isoform sequencing (PAIso−seq) reveals wide-spread non-adenosine residues within RNA poly(A) tails

The poly(A) tails on mRNA are vital for their function but it is difficult to map full-length sequences of mRNA isoforms with the entire poly(A) tails. Here the authors develop PAIso−seq which can measure isoform specific poly(A) tail length and base composition at single-cell sensitivity.

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Autores principales:	Yusheng Liu, Hu Nie, Hongxiang Liu, Falong Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/012546e7cfb74be0bde67f2db1e1201e
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spelling	oai:doaj.org-article:012546e7cfb74be0bde67f2db1e1201e2021-12-02T15:35:14ZPoly(A) inclusive RNA isoform sequencing (PAIso−seq) reveals wide-spread non-adenosine residues within RNA poly(A) tails10.1038/s41467-019-13228-92041-1723https://doaj.org/article/012546e7cfb74be0bde67f2db1e1201e2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13228-9https://doaj.org/toc/2041-1723The poly(A) tails on mRNA are vital for their function but it is difficult to map full-length sequences of mRNA isoforms with the entire poly(A) tails. Here the authors develop PAIso−seq which can measure isoform specific poly(A) tail length and base composition at single-cell sensitivity.Yusheng LiuHu NieHongxiang LiuFalong LuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yusheng Liu Hu Nie Hongxiang Liu Falong Lu Poly(A) inclusive RNA isoform sequencing (PAIso−seq) reveals wide-spread non-adenosine residues within RNA poly(A) tails
description	The poly(A) tails on mRNA are vital for their function but it is difficult to map full-length sequences of mRNA isoforms with the entire poly(A) tails. Here the authors develop PAIso−seq which can measure isoform specific poly(A) tail length and base composition at single-cell sensitivity.
format	article
author	Yusheng Liu Hu Nie Hongxiang Liu Falong Lu
author_facet	Yusheng Liu Hu Nie Hongxiang Liu Falong Lu
author_sort	Yusheng Liu
title	Poly(A) inclusive RNA isoform sequencing (PAIso−seq) reveals wide-spread non-adenosine residues within RNA poly(A) tails
title_short	Poly(A) inclusive RNA isoform sequencing (PAIso−seq) reveals wide-spread non-adenosine residues within RNA poly(A) tails
title_full	Poly(A) inclusive RNA isoform sequencing (PAIso−seq) reveals wide-spread non-adenosine residues within RNA poly(A) tails
title_fullStr	Poly(A) inclusive RNA isoform sequencing (PAIso−seq) reveals wide-spread non-adenosine residues within RNA poly(A) tails
title_full_unstemmed	Poly(A) inclusive RNA isoform sequencing (PAIso−seq) reveals wide-spread non-adenosine residues within RNA poly(A) tails
title_sort	poly(a) inclusive rna isoform sequencing (paiso−seq) reveals wide-spread non-adenosine residues within rna poly(a) tails
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/012546e7cfb74be0bde67f2db1e1201e
work_keys_str_mv	AT yushengliu polyainclusivernaisoformsequencingpaisoseqrevealswidespreadnonadenosineresidueswithinrnapolyatails AT hunie polyainclusivernaisoformsequencingpaisoseqrevealswidespreadnonadenosineresidueswithinrnapolyatails AT hongxiangliu polyainclusivernaisoformsequencingpaisoseqrevealswidespreadnonadenosineresidueswithinrnapolyatails AT falonglu polyainclusivernaisoformsequencingpaisoseqrevealswidespreadnonadenosineresidueswithinrnapolyatails
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Poly(A) inclusive RNA isoform sequencing (PAIso−seq) reveals wide-spread non-adenosine residues within RNA poly(A) tails

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