Th17/IL-17A might play a protective role in chronic lymphocytic leukemia immunity.

Th17 cells, a recently discovered subset of T helper cells that secrete IL-17A, can affect the inflammation process autoimmune and cancer diseases development. The purpose of this study was to evaluate the role of Th17 cells and IL17A in biology of CLL. The study group included 294 untreated CLL pat...

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Autores principales:	Iwona Hus, Agnieszka Bojarska-Junak, Sylwia Chocholska, Waldemar Tomczak, Justyna Woś, Anna Dmoszyńska, Jacek Roliński
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0125662e64694743bde82038d5ca9420
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spelling	oai:doaj.org-article:0125662e64694743bde82038d5ca94202021-11-18T08:48:46ZTh17/IL-17A might play a protective role in chronic lymphocytic leukemia immunity.1932-620310.1371/journal.pone.0078091https://doaj.org/article/0125662e64694743bde82038d5ca94202013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223764/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Th17 cells, a recently discovered subset of T helper cells that secrete IL-17A, can affect the inflammation process autoimmune and cancer diseases development. The purpose of this study was to evaluate the role of Th17 cells and IL17A in biology of CLL. The study group included 294 untreated CLL patients in different clinical stages. Here, we show that higher Th17 and IL-17A values were associated with less advanced clinical stage of CLL. Th17 cells' percentages in PB were lower in patients who died due to CLL during follow-up due to CLL (as compared to surviving patients) and in patients responding to first-line therapy with fludarabine-based regimens (as compared to non-responders). IL-17A inversely correlated with the time from CLL diagnosis to the start of therapy and was lower in patients who required treatment during follow-up. Th-17 and IL-17A values were lower in patients with adverse prognostic factors (17p and 11q deletion, CD38 and ZAP-70 expression). CLL patients with detectable IL-17A mRNA in T cells were in Rai Stage 0 and negative for both ZAP-70 and CD38 expression. Th17 percentages positively correlated with iNKT and adversely with Treg cells. The results of this study suggest that Th17 may play a beneficial role in CLL immunity.Iwona HusAgnieszka Bojarska-JunakSylwia ChocholskaWaldemar TomczakJustyna WośAnna DmoszyńskaJacek RolińskiJacek RolińskiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e78091 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Iwona Hus Agnieszka Bojarska-Junak Sylwia Chocholska Waldemar Tomczak Justyna Woś Anna Dmoszyńska Jacek Roliński Jacek Roliński Th17/IL-17A might play a protective role in chronic lymphocytic leukemia immunity.
description	Th17 cells, a recently discovered subset of T helper cells that secrete IL-17A, can affect the inflammation process autoimmune and cancer diseases development. The purpose of this study was to evaluate the role of Th17 cells and IL17A in biology of CLL. The study group included 294 untreated CLL patients in different clinical stages. Here, we show that higher Th17 and IL-17A values were associated with less advanced clinical stage of CLL. Th17 cells' percentages in PB were lower in patients who died due to CLL during follow-up due to CLL (as compared to surviving patients) and in patients responding to first-line therapy with fludarabine-based regimens (as compared to non-responders). IL-17A inversely correlated with the time from CLL diagnosis to the start of therapy and was lower in patients who required treatment during follow-up. Th-17 and IL-17A values were lower in patients with adverse prognostic factors (17p and 11q deletion, CD38 and ZAP-70 expression). CLL patients with detectable IL-17A mRNA in T cells were in Rai Stage 0 and negative for both ZAP-70 and CD38 expression. Th17 percentages positively correlated with iNKT and adversely with Treg cells. The results of this study suggest that Th17 may play a beneficial role in CLL immunity.
format	article
author	Iwona Hus Agnieszka Bojarska-Junak Sylwia Chocholska Waldemar Tomczak Justyna Woś Anna Dmoszyńska Jacek Roliński Jacek Roliński
author_facet	Iwona Hus Agnieszka Bojarska-Junak Sylwia Chocholska Waldemar Tomczak Justyna Woś Anna Dmoszyńska Jacek Roliński Jacek Roliński
author_sort	Iwona Hus
title	Th17/IL-17A might play a protective role in chronic lymphocytic leukemia immunity.
title_short	Th17/IL-17A might play a protective role in chronic lymphocytic leukemia immunity.
title_full	Th17/IL-17A might play a protective role in chronic lymphocytic leukemia immunity.
title_fullStr	Th17/IL-17A might play a protective role in chronic lymphocytic leukemia immunity.
title_full_unstemmed	Th17/IL-17A might play a protective role in chronic lymphocytic leukemia immunity.
title_sort	th17/il-17a might play a protective role in chronic lymphocytic leukemia immunity.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/0125662e64694743bde82038d5ca9420
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Th17/IL-17A might play a protective role in chronic lymphocytic leukemia immunity.

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