Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer

Abstract Background Colorectal cancer is a common malignancy occurring in the digestive system and ranks second in cancer mortality worldwide. In colorectal cancer, hydrogen sulfide (H2S) is selectively upregulated, resulting in the further exacerbation of the disease. Therefore, the clearance of H2...

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Autores principales:	Xiang Pan, Yuchen Qi, Zhen Du, Jian He, Sheng Yao, Wei Lu, Kefeng Ding, Min Zhou
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Zinc oxide nanoparticles Hydrogen sulfide Colorectal cancer Ferroptosis Nanoengineering Glutathione Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/0126d63559d24b92ba373de994b0d458
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spelling	oai:doaj.org-article:0126d63559d24b92ba373de994b0d4582021-11-28T12:26:36ZZinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer10.1186/s12951-021-01069-y1477-3155https://doaj.org/article/0126d63559d24b92ba373de994b0d4582021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01069-yhttps://doaj.org/toc/1477-3155Abstract Background Colorectal cancer is a common malignancy occurring in the digestive system and ranks second in cancer mortality worldwide. In colorectal cancer, hydrogen sulfide (H2S) is selectively upregulated, resulting in the further exacerbation of the disease. Therefore, the clearance of H2S and the regulation of the enzymes on the H2S pathways are of great significance for colorectal cancer therapy. Methods Here, we investigated the H2S content in various clinical tumor tissues from patients and confirmed that overproduced concentration of H2S in colorectal cancer. Accordingly, we developed an H2S-responsive nanoplatform based on zinc oxide coated virus-like silica nanoparticles (VZnO) for the therapy of colorectal cancer. Results Owing to its excellent H2S scavenging ability, VZnO could effectively reduce H2S content in colorectal cancer to prohibit the growth of CT26 and HCT116 colorectal cancer cells. Moreover, the removal of H2S in colorectal cancer also leads to tumor inhibition through activating ferroptosis, a non-apoptotic form of cell death. The biosafety-related toxicological and pathological analysis confirmed the low toxicity and high safety of VZnO in colorectal cancer treatment. Furthermore, as an H2S-responsible nanosystem, VZnO appears to have no therapeutic effect on other non H2S rich cancers, such as the 4T1 breast cancer model. Conclusions We anticipate that the H2S-depletion-induced ferroptosis strategy using zinc oxide-based nanomaterials would provide insights in designing nanomedicines for colorectal cancer-target theranostics and may offer clinical promise. Graphic abstractXiang PanYuchen QiZhen DuJian HeSheng YaoWei LuKefeng DingMin ZhouBMCarticleZinc oxide nanoparticlesHydrogen sulfideColorectal cancerFerroptosisNanoengineeringGlutathioneBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Zinc oxide nanoparticles Hydrogen sulfide Colorectal cancer Ferroptosis Nanoengineering Glutathione Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Zinc oxide nanoparticles Hydrogen sulfide Colorectal cancer Ferroptosis Nanoengineering Glutathione Biotechnology TP248.13-248.65 Medical technology R855-855.5 Xiang Pan Yuchen Qi Zhen Du Jian He Sheng Yao Wei Lu Kefeng Ding Min Zhou Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer
description	Abstract Background Colorectal cancer is a common malignancy occurring in the digestive system and ranks second in cancer mortality worldwide. In colorectal cancer, hydrogen sulfide (H2S) is selectively upregulated, resulting in the further exacerbation of the disease. Therefore, the clearance of H2S and the regulation of the enzymes on the H2S pathways are of great significance for colorectal cancer therapy. Methods Here, we investigated the H2S content in various clinical tumor tissues from patients and confirmed that overproduced concentration of H2S in colorectal cancer. Accordingly, we developed an H2S-responsive nanoplatform based on zinc oxide coated virus-like silica nanoparticles (VZnO) for the therapy of colorectal cancer. Results Owing to its excellent H2S scavenging ability, VZnO could effectively reduce H2S content in colorectal cancer to prohibit the growth of CT26 and HCT116 colorectal cancer cells. Moreover, the removal of H2S in colorectal cancer also leads to tumor inhibition through activating ferroptosis, a non-apoptotic form of cell death. The biosafety-related toxicological and pathological analysis confirmed the low toxicity and high safety of VZnO in colorectal cancer treatment. Furthermore, as an H2S-responsible nanosystem, VZnO appears to have no therapeutic effect on other non H2S rich cancers, such as the 4T1 breast cancer model. Conclusions We anticipate that the H2S-depletion-induced ferroptosis strategy using zinc oxide-based nanomaterials would provide insights in designing nanomedicines for colorectal cancer-target theranostics and may offer clinical promise. Graphic abstract
format	article
author	Xiang Pan Yuchen Qi Zhen Du Jian He Sheng Yao Wei Lu Kefeng Ding Min Zhou
author_facet	Xiang Pan Yuchen Qi Zhen Du Jian He Sheng Yao Wei Lu Kefeng Ding Min Zhou
author_sort	Xiang Pan
title	Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer
title_short	Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer
title_full	Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer
title_fullStr	Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer
title_full_unstemmed	Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer
title_sort	zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/0126d63559d24b92ba373de994b0d458
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Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer

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