Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone

This essay analyzes the scientific evidence that forms the basis of bioactive materials, covering the fundamental understanding of bioactivity phenomena and correlation with the mechanisms of biocompatibility of biomaterials. This is a detailed assessment of performance in areas such as bone-inducti...

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Autor principal:	David F. Williams
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Bioactivity Host response Biomaterial Medical technology Cell signaling Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0127e40610ac43f598cc69a9280b082d
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spelling	oai:doaj.org-article:0127e40610ac43f598cc69a9280b082d2021-11-28T04:35:07ZBiocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone2452-199X10.1016/j.bioactmat.2021.08.014https://doaj.org/article/0127e40610ac43f598cc69a9280b082d2022-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X2100390Xhttps://doaj.org/toc/2452-199XThis essay analyzes the scientific evidence that forms the basis of bioactive materials, covering the fundamental understanding of bioactivity phenomena and correlation with the mechanisms of biocompatibility of biomaterials. This is a detailed assessment of performance in areas such as bone-induction, cell adhesion, immunomodulation, thrombogenicity and antimicrobial behavior. Bioactivity is the modulation of biological activity by characteristics of the interfacial region that incorporates the material surface and the immediate local host tissue. Although the term ‘bioactive material’ is widely used and has a well understood general meaning, it would be useful now to concentrate on this interfacial region, considered as ‘the bioactivity zone’. Bioactivity phenomena are either due to topographical/micromechanical characteristics, or to biologically active species that are presented in the bioactivity zone. Examples of topographical/micromechanical effects are the modulation of the osteoblast – osteoclast balance, nanotopographical regulation of cell adhesion, and bactericidal nanostructures. Regulation of bioactivity by biologically active species include their influence, especially of metal ions, on signaling pathways in bone formation, the role of cell adhesion molecules and bioactive peptides in cell attachment, macrophage polarization by immunoregulatory molecules and antimicrobial peptides. While much experimental data exists to demonstrate the potential of such phenomena, there are considerable barriers to their effective clinical translation. This essay shows that there is solid scientific evidence of the existence of bioactivity mechanisms that are associated with some types of biomaterials, especially when the material is modified in a manner designed to specifically induce that activity.David F. WilliamsKeAi Communications Co., Ltd.articleBioactivityHost responseBiomaterialMedical technologyCell signalingMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 10, Iss , Pp 306-322 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bioactivity Host response Biomaterial Medical technology Cell signaling Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Bioactivity Host response Biomaterial Medical technology Cell signaling Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 David F. Williams Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone
description	This essay analyzes the scientific evidence that forms the basis of bioactive materials, covering the fundamental understanding of bioactivity phenomena and correlation with the mechanisms of biocompatibility of biomaterials. This is a detailed assessment of performance in areas such as bone-induction, cell adhesion, immunomodulation, thrombogenicity and antimicrobial behavior. Bioactivity is the modulation of biological activity by characteristics of the interfacial region that incorporates the material surface and the immediate local host tissue. Although the term ‘bioactive material’ is widely used and has a well understood general meaning, it would be useful now to concentrate on this interfacial region, considered as ‘the bioactivity zone’. Bioactivity phenomena are either due to topographical/micromechanical characteristics, or to biologically active species that are presented in the bioactivity zone. Examples of topographical/micromechanical effects are the modulation of the osteoblast – osteoclast balance, nanotopographical regulation of cell adhesion, and bactericidal nanostructures. Regulation of bioactivity by biologically active species include their influence, especially of metal ions, on signaling pathways in bone formation, the role of cell adhesion molecules and bioactive peptides in cell attachment, macrophage polarization by immunoregulatory molecules and antimicrobial peptides. While much experimental data exists to demonstrate the potential of such phenomena, there are considerable barriers to their effective clinical translation. This essay shows that there is solid scientific evidence of the existence of bioactivity mechanisms that are associated with some types of biomaterials, especially when the material is modified in a manner designed to specifically induce that activity.
format	article
author	David F. Williams
author_facet	David F. Williams
author_sort	David F. Williams
title	Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone
title_short	Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone
title_full	Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone
title_fullStr	Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone
title_full_unstemmed	Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone
title_sort	biocompatibility pathways and mechanisms for bioactive materials: the bioactivity zone
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/0127e40610ac43f598cc69a9280b082d
work_keys_str_mv	AT davidfwilliams biocompatibilitypathwaysandmechanismsforbioactivematerialsthebioactivityzone
_version_	1718408298092298240

Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone

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